Hubungan Gejala Kolesistolitiasis dengan Kejadian Gastritis dan Karakteristiknya

Hardianto Setiawan, Rio Saputra, Yohanes Firmansyah, Fernando Nathaniel, Giovanno Sebastian Yogie

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ABSTRACT

 

Cholecystolithiasis and gastritis are both very common conditions in the modern era, and they can occur together. The relationship between cholecystolithiasis and gastritis in terms of their characteristics and clinical implications is not yet fully understood. This study aims to determine the association between cholecystolithiasis symptoms and the occurrence of gastritis as observed through endoscopy, along with the analysis of their characteristics. This study employed a cross-sectional design with a total of 114 participants obtained from medical records of several hospitals in Jakarta from January 2020 to 2023. Data analysis was conducted using Pearson Chi-Square test with Yates Correction and Fisher's exact test to test the hypotheses. The results of the study showed no significant association between gender, H. pylori infection, and bile reflux with positive endoscopy results for gastritis in patients with cholecystolithiasis (p > 0.05). Clinical exploration revealed that male gender, H. pylori infection, and the presence of bile reflux symptoms did have a higher risk for positive endoscopy results [PR: 1.152 (0.996 - 1.333) vs. 1.169 (1.080 - 1.264) vs. 1.165 (1.078 - 1.258)]. There was a significant association between gastrointestinal symptoms and positive endoscopy results (PR: 1.802, p-value < 0.001). Abdominal pain obtained a 100% value for positive endoscopy results of gastritis in patients diagnosed with cholecystolithiasis. There is no significant association between gender, H. pylori infection, and bile reflux with the occurrence of gastritis in patients with cholecystolithiasis. However, there is a significant association between gastrointestinal symptoms and positive endoscopy results, with abdominal pain being the most strongly associated symptom.

 

Keywords : Cholecystolithiasis, Gastritis, Risk factors

 

 

ABSTRAK

 

Kolesistolitiasis dan gastritis keduanya merupakan kondisi yang sangat umum di era modern dan kejadian tersebut dapat terjadi secara bersamaan. Hubungan antara kolesistolitiasis dengan gastritis ditinjau dari karakteristiknya serta implikasi klinisnya masih belum sepenuhnya dipahami. Studi ini bertujuan untuk mengetahui hubungan gejala kolesistolitiasis dengan kejadian gastritis yang ditinjau dari endoskopi beserta analisis karakteristiknya. Penelitian ini menggunakan desain penelitian potong lintang dengan total 114 partisipan yang diperoleh dari rekam medis dari beberapa rumah sakit di Jakarta periode januari 2020 hingga 2023. Analisis data dilakukan dengan menggunakan uji statistik Pearson Chi Square with Yates Correction dan Fisher Exact untuk menguji hipotesis. Hasil penelitian menunjukan tidak ada hubungan yang signifikan antara jenis kelamin, infeksi H.pylori, dan bile reflux  dengan hasil endoskopi positif untuk gastritis pada pasien kolesistolitiasis (p > 0,05). Penelusuran secara klinis mengungkapkan bahwa jenis kelamin laki-laki, infeksi H. pylori dan adanya gejala bile reflux  memang memiliki risiko lebih tinggi untuk hasil endoskopi positif [PR: 1,152 (0,996 - 1,333) v.s 1,169 (1,080 - 1,264) v.s. 1,165 (1,078 - 1,258)]. Terdapat hubungan yang signifikan antara gejala gastrointestinal dengan hasil endoskopi yang positif (PR: 1,802, nilai p <0,001). Keluhan nyeri perut mendapatkan nilai 100% untuk hasil endoskopi positif gastritis pada pasien telah terdiagnosis kolesistolitiasis. Tidak ada hubungan yang signifikan antara jenis kelamin, infeksi h.pylori, dan bile reflux  dengan kejadian gastritis pada pasien kolesistolitiasis. Namun terdapat hubungan signifikan antara gejala gastrointestinal dengan hasil endoskopi yang positif, dimana keluhan nyeri perut memiliki kejadian yang paling kuat.

 

Kata Kunci: Faktor Risiko, Gastritis, Kolesistolitiasis


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Referensi


Ari, A., Tatar, C., & Yarikkaya, E. (2019). Relationship Between Helicobacter Pylori-Positivity In The Gallbladder And Stomach And Effect On Gallbladder Pathologies. Journal Of International Medical Research, 47(10), 4904–4910. Https://Doi.Org/10.1177/0300060519847345

Azer, S., & Akhondi, H. (2023). Gastritis. In Statpearls. Statpearls Publishing.

Barakat, E. A. M. E., Abbas, N. F., & El-Kholi, N. Y. (2018). Primary Bile Reflux Gastritis Versus Helicobacter Pylori Gastritis: A Comparative Study. The Egyptian Journal Of Internal Medicine, 30(1), 23–27. Https://Doi.Org/10.4103/Ejim.Ejim_42_17

Cen, L., Pan, J., Zhou, B., Yu, C., Li, Y., Chen, W., & Shen, Z. (2018). Helicobacter Pylori Infection Of The Gallbladder And The Risk Of Chronic Cholecystitis And Cholelithiasis: A Systematic Review And Meta-Analysis. Helicobacter, 23(1), E12457. Https://Doi.Org/10.1111/Hel.12457

Chen, L., Zhu, G., She, L., Ding, Y., Yang, C., & Zhu, F. (2021). Analysis Of Risk Factors And Establishment Of A Prediction Model For Endoscopic Primary Bile Reflux: A Single-Center Retrospective Study. Frontiers In Medicine, 8. Https://Doi.Org/10.3389/Fmed.2021.758771

Eslami, B., Iranshahi, M., Gachkar, L., & Hadavand, F. (2021). Gallstone Frequency In Patients With Helicobacter Pylori Gastritis. Archives Of Clinical Infectious Diseases, 16(1), 1–3. Https://Doi.Org/10.5812/Archcid.100805

Higashizono, K., Nakatani, E., Hawke, P., Fujimoto, S., & Oba, N. (2022). Risk Factors For Gallstone Disease Onset In Japan: Findings From The Shizuoka Study, A Population-Based Cohort Study. Plos One, 17(12), E0274659. Https://Doi.Org/10.1371/Journal.Pone.0274659

Housset, C., Chrétien, Y., Debray, D., & Chignard, N. (2016). Functions Of The Gallbladder. Comprehensive Physiology, 6(3), 1549–1577. Https://Doi.Org/10.1002/Cphy.C150050

Jones, M., Weir, C., & Ghassemzadeh, S. (2023). Gallstones (Cholelithiasis). In Statpearls. Statpearls Publishing.

Latenstein, C. S. S., De Jong, J., Eppink, J. J., Lantiga, M. A., Van Laarhoven, C. J. H. ., De Reuver, P. R., & Drenth, J. P. H. (2019). Prevalence Of Dyspepsia In Patients With Cholecystolithiasis: A Systematic Review And Meta-Analysis. European Journal Of Gastroenterology & Hepatology, 31(8), 928–934. Https://Doi.Org/10.1097/Meg.0000000000001463

Littlefield, A., & Lenahan, C. (2019). Cholelithiasis: Presentation And Management. Journal Of Midwifery & Women’s Health, 64(3), 289–297.Https://Doi.Org/10.1111/Jmwh.12959

Mccabe, M. E., & Dilly, C. K. (2018). New Causes For The Old Problem Of Bile Reflux Gastritis. Clinical Gastroenterology And Hepatology, 16(9), 1389–1392. Https://Doi.Org/10.1016/J.Cgh.2018.02.034

Memon, A. I., Naz, S., Memon, R. A., Bhatti, A. M., Nayab, ., & Ali, M. (2022). Prevalence Of Helicobacter Pylori Gastritis Among Patients With Symptomatic Cholelithiasis. Journal Of Pharmaceutical Research International, 34, 1–5. Https://Doi.Org/10.9734/Jpri/2022/V34i33a36120

Nordenstedt, H., Graham, D. Y., Kramer, J. R., Rugge, M., Verstovsek, G., Fitzgerald, S., Alsarraj, A., Shaib, Y., Velez, M. E., Abraham, N., Anand, B., Cole, R., & El-Serag, H. B. (2013). Helicobacter Pylori -Negative Gastritis: Prevalence And Risk Factors. American Journal Of Gastroenterology, 108(1), 65–71. Https://Doi.Org/10.1038/Ajg.2012.372

Pak, M., & Lindseth, G. (2016). Risk Factors For Cholelithiasis. Gastroenterology Nursing, 39(4), 297–309. Https://Doi.Org/10.1097/Sga.0000000000000235

Pennelli, G., Grillo, F., Galuppini, F., Ingravallo, G., Pilozzi, E., Rugge, M., Fiocca, R., Fassan, M., & Mastracci, L. (2020). Gastritis: Update On Etiological Features And Histological Practical Approach. Pathologica, 112(3), 153–165. Https://Doi.Org/10.32074/1591-951x-163

Qiao, T., Ma, R. Hong, Luo, X. Bing, Luo, Z. Liang, & Zheng, P. Ming. (2012). Cholecystolithiasis Is Associated With Clonorchis Sinensis Infection. Plos One, 7(8), 1–10. Https://Doi.Org/10.1371/Journal.Pone.0042471

Rehfeld, J. F. (2017). Cholecystokinin-From Local Gut Hormone To Ubiquitous Messenger. Frontiers In Endocrinology, 8(Apr), 1–8. Https://Doi.Org/10.3389/Fendo.2017.00047

Sigmon, D., Dayal, N., & Meseeha, M. (2023). Biliary Colic. In Statpearls. Statpearls Publishing.

Svistunov, A., Osadchuk, M., Mironova, E. D., & Vasil’eva, I. N. (2021). Helicobacter Pylori As A Risk Factor For The Development Of Metabolic Syndrome And Gallstone Disease. Medical News Of The North Caucasus, 16(2). Https://Doi.Org/10.14300/Mnnc.2021.16030

Szőke, A., Mocan, S., & Negovan, A. (2021). Helicobacter Pylori Infection Over Bile Reflux: No Influence On The Severity Of Endoscopic Or Premalignant Gastric Lesion Development . Experimental And Therapeutic Medicine, 22(1), 1–6. Https://Doi.Org/10.3892/Etm.2021.10198

Toyoshima, O., Nishizawa, T., Yoshida, S., Sakaguchi, Y., Nakai, Y., Watanabe, H., Suzuki, H., Tanikawa, C., Matsuda, K., & Koike, K. (2020). Endoscopy-Based Kyoto Classification Score Of Gastritis Related To Pathological Topography Of Neutrophil Activity. World Journal Of Gastroenterology, 26(34), 51465155.Https://Doi.Org/10.3748/Wjg.V26.I34.5146

Zhang, F. M., Yu, C. H., Chen, H. T., Shen, Z., Hu, F. L., Yuan, X. P., & Xu, G. Q. (2015). Helicobacter Pylori Infection Is Associated With Gallstones: Epidemiological Survey In China. World Journal Of Gastroenterology, 21(29), 8964–8973. Https://Doi.Org/10.3748/Wjg.V21.I29.8912




DOI: https://doi.org/10.33024/mahesa.v3i9.11116

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