Clinical Manifestations of the Gastrointestinal System in Patients with SARS-CoV-2 Infection

Kharizmatika Kharizmatika, Judya Sukmana, Roostantia Indrawati, Christian Bambang Sulistio

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ABSTRACT

 

SARS-CoV-2 infection was declared as a pandemic by the WHO since March 11, 2020, with confirmed cases increasing every year. SARS-CoV-2 is one of the varian of coronavirus that has a higher transmission rate, where it is transmitted through infected droplets. SARS-CoV-2 can manifest in the digestive tract. This descriptive study uses a literature study method. Diarrhea was a common symptom of gastrointestinal manifestations in COVID-19 patients. Apart from diarrhea, other symptoms are anorexia, nausea, vomiting and abdominal pain. Gender prevalence varies. The average age of patients exposed to COVID-19 was over 50 years with hypertension as the most common comorbidity. SARS-CoV-2 are associated with Gastrointestinal manifestations which binds to ACE2 on gastrointestinal epithelial cells. SARS-CoV-2 infection causes an imbalance in the gut microbiota that can trigger secondary infections and multiple organ disorders and affect the severity of COVID-19.

 

Keywords: COVID-19, Gastrointestinal Symptoms, ACE2, Gut Microbiota, Gut-Lung Axis


Referensi


Anggreni, D., & Safitri, C. A. (2020). Hubungan pengetahuan remaja tentang covid-19 dengan kepatuhan dalam menerapkan protokol kesehatan di masa new normal. Hospital Majapahit (Jurnal Ilmiah Kesehatan Politeknik Kesehatan Majapahit Mojokerto), 12(2), 134-142.

Aumpan, N., Nunanan, P., & Vilaichone, R. K. (2020). Gastrointestinal manifestation as clinical predictor of severe COVID-19: A retrospective experience and literature review of COVID-19 in Association of Southeast Asian Nations (ASEAN). JGH Open, 4(6), 1096-1101.

Cholankeril, G., Podboy, A., Aivaliotis, V. I., Pham, E. A., Spencer, S. P., Kim, D., et al. (2020). Association of digestive symptoms and hospitalization in patients with SARS-CoV-2 infection. The American Journal of Gastroenterology, 115(7). Retrieved from https://journals.lww.com/ajg/Fulltext/2020/07000/Association_of_Digestive_Symptoms_and.28.aspx

Cholankeril, G., Podboy, A., Aivaliotis, V. I., Tarlow, B., Pham, E. A., Spencer, S. P., et al. (2020). High prevalence of concurrent gastrointestinal manifestations in patients with severe acute respiratory syndrome coronavirus 2: Early experience from California. Gastroenterology, 159(2), 775-777. https://doi.org/10.1053/j.gastro.2020.04.008

Graham, G., Taegtmeyer, M., Lewis, J., & Subramanian, S. (2021). Gastrointestinal symptoms involvement in hospitalised COVID-19 patients in Liverpool, UK: A descriptive cross-sectional, single-centre study. Clinical Medicine Journal of the Royal College of Physicians of London, 21(Suppl 2), S23-S24.

Han, C., Duan, C., Zhang, S., Spiegel, B., Shi, H., Wang, W., et al. (2020). Digestive symptoms in COVID-19 patients with mild disease severity: Clinical presentation, stool viral RNA testing, and outcomes. The American Journal of Gastroenterology, 115(6). Retrieved from https://journals.lww.com/ajg/Fulltext/2020/06000/Digestive_Symptoms_in_COVID_19_Patients_With_Mild.21.aspx

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., et al. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395(10223), 497-506.

Jin, X., Lian, J. S., Hu, J. H., Gao, J., Zheng, L., Zhang, Y. M., et al. (2020). Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut, 69(6), 1002-1009.

Lin, L., Jiang, X., Zhang, Z., Huang, S., Zhang, Z., Fang, Z., et al. (2020). Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut, 69(6), 997-1001.

Nasution, N. H., & Hidayah, A. (2021). Gambaran pengetahuan masyarakat tentang pencegahan covid-19 di kecamatan padangsidimpuan batunadua, kota padangsidimpuan. Jurnal Kesehatan Ilmiah Indonesia (Indonesian Health Scientific Journal), 6(1), 107-114.

Pan, L., Mu, M., Yang, P., Sun, Y., Wang, R., Yan, J., et al. (2020). Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: A descriptive, cross-sectional, multicenter study. The American Journal of Gastroenterology, 115(5), 766-773.

Papa, A., Covino, M., Pizzolante, F., Miele, L., Lopetuso, L. R., Bove, V., et al. (2020). Gastrointestinal symptoms and digestive comorbidities in an Italian cohort of patients with COVID-19. European Review for Medical and Pharmacological Sciences, 24(13), 7506-7511.

Pizuorno, A., Brim, H., & Ashktorab, H. (2021). Gastrointestinal manifestations and SARS-CoV-2 infection. Current Opinion in Pharmacology, 61, 114-119.

Ramachandran, P., Onukogu, I., Ghanta, S., Gajendran, M., Perisetti, A., Goyal, H., et al. (2020). Gastrointestinal symptoms and outcomes in hospitalized coronavirus disease 2019 patients. Digestive Diseases, 38(5), 373-379.

Sibero, I., Hulu, V. T., Pakpahan, E. L. E., & Siahaan, P. B. C. (2023). Pengalaman Hidup Pasien Covid-19 Di Rumah Sakit Umum Delia Tahun 2021: Sebuah Studi Kualitatif. Jurnal Kesehatan Tambusai, 4(2), 2346-2357.

Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., et al. (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA, 323(11), 1061-1069.

Wang, F., Yang, Y., Dong, K., Yan, Y., Zhang, S., Ren, H., et al. (2020). Clinical characteristics of 28 patients with diabetes and COVID-19 in Wuhan, China. Endocrine Practice, 26(6), 668-674.

Wang, J., Li, F., Wei, H., Lian, Z.-X., Sun, R., & Tian, Z. (2014). Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation. Journal of Experimental Medicine, 211(12), 2397-2410. https://doi.org/

World Health Organization. (2020). Coronavirus disease (COVID-19) pandemic. Retrieved March 11, 2020, from https://www.who.int/emergencies/diseases/novel-coronavirus-2019

World Health Organization. (2021). Coronavirus disease (COVID-19) pandemic. Retrieved July 15, 2021, from https://www.who.int/emergencies/diseases/novel-coronavirus-2019

Wu, Z., & McGoogan, J. M. (2020). Characteristics of and important lessons from the Coronavirus Disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA, 323(13), 1239-1242. https://doi.org/10.1001/jama.2020.2648

Xu, X. W., Wu, X. X., Jiang, X. G., Xu, K. J., Ying, L. J., Ma, C. L., et al. (2020). Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-CoV-2) outside of Wuhan, China: Retrospective case series. BMJ, 368, 1-7.

Zhang, J. J., Dong, X., Cao, Y. Y., Yuan, Y. D., Yang, Y. B., Yan, Y. Q., et al. (2020). Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy, 75(7), 1730-1741.




DOI: https://doi.org/10.33024/mahesa.v4i10.15845

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