The Assessment of Neutrophil-to-Lymphocyte Ratio in Obesity: A Descriptive Study on University Students in Surabaya, Indonesia

Inggit Damayanti, Budiono Raharjo, Heru Setiawan, Wike Herawaty, Stephani Linggawan, Anton Sumarpo, Siprianus Ugroseno Yudho Bintoro

Sari


ABSTRACT

 

The incidence of obesity worldwide is rapidly increasing, both in developed and developing countries. Obesity, particularly central obesity, is an inflammatory condition occurring within the body. The neutrophil-to-lymphocyte ratio (NLR) is a simple biomarker used to indicate the inflammatory response. This study aims to determine the profile of the neutrophil-to-lymphocyte ratio in students with obesity at the Faculty of Medicine, Universitas Wijaya Kusuma Surabaya.  This study employs a descriptive-analytic method with a cross-sectional approach. The study population comprises students from the Faculty of Medicine, Universitas Wijaya Kusuma Surabaya; 47 individuals, with 30 obese individuals and 17 individuals with a normal BMI. The results showed that the average neutrophil-to-lymphocyte ratio (NLR) for individuals with a normal BMI is 1,95. In contrast, the average NLR for obese individuals is 2,09. There is an increase in the average neutrophil-to-lymphocyte ratio (NLR) among obese students at the Faculty of Medicine, Universitas Wijaya Kusuma Surabaya.

 

Keywords: Obesity, Neutrophil, Lymphocyte, Neutrophil-To-Lymphocyte Ratio


Referensi


Azab, B., Camacho-Rivera, M., & Taioli, E. (2014). Average values and racial differences of neutrophil lymphocyte ratio among a nationally representative sample of United States subjects. PloS One, 9(11), e112361. https://doi.org/10.1371/journal.pone.0112361

Buonacera, A., Stancanelli, B., Colaci, M., & Malatino, L. (2022). Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases. International Journal of Molecular Sciences, 23(7), 3636. https://doi.org/10.3390/ijms23073636

Chapman, N. M., & Chi, H. (2022). Metabolic adaptation of lymphocytes in immunity and disease. Immunity, 55(1), 14–30. https://doi.org/10.1016/j.immuni.2021.12.012

Dirican, A., Kucukzeybek, B. B., Alacacioglu, A., Kucukzeybek, Y., Erten, C., Varol, U., Somali, I., Demir, L., Bayoglu, I. V., Yildiz, Y., Akyol, M., Koyuncu, B., Coban, E., Ulger, E., Unay, F. C., & Tarhan, M. O. (2015). Do the derived neutrophil to lymphocyte ratio and the neutrophil to lymphocyte ratio predict prognosis in breast cancer? International Journal of Clinical Oncology, 20(1), 70–81.https://doi.org/10.1007/s10147-014-0672-8

Fisher, A., Srikusalanukul, W., Fisher, L., & Smith, P. (2016). The Neutrophil to Lymphocyte Ratio on Admission and Short-Term Outcomes in Orthogeriatric Patients. International Journal of Medical Sciences, 13(8), 588–602.https://doi.org/10.7150/ijms.15445

Gunawan, S. P., & Adriana, M. (2020). Obesitas dan Tingkat Stres Berhubungan dengan Hipertensi pada Orang Dewasa di Kelurahan Klampis Ngasem, Surabaya . Media Gizi Indonesia, 15(2), 119. https://doi.org/10.20473/mgi.v15i2.119-126

Indrati, A. R., Sumarpo, A., Atmadja, P., Wisesa, R. R., Ghozali, M., Judistiani, R. T. D., & Setiabudiawan, B. (2022). Exploring alternative cytokines as potential biomarkers for latent tuberculosis infection in pregnant women. PLoS ONE, 17(7 July). https://doi.org/10.1371/journal.pone.0270552

Indrati, A., Sumarpo, A., Haryanto, J., Rosmiati, N., Munaya, S., Turbawaty, D., & Wisaksana, R. (2024). Identification of cytokine signatures in HIV infected individuals with and without Mycobacterium tuberculosis co infection. Biomedical Reports, 21(3), 131.https://doi.org/10.3892/br.2024.1819

Mraz, M., & Haluzik, M. (2014). The role of adipose tissue immune cells in obesity and low-grade inflammation. The Journal of Endocrinology, 222(3), R113-27. https://doi.org/10.1530/JOE-14-0283

Nuttall, F. Q. (2015). Body Mass Index: Obesity, BMI, and Health: A Critical Review. Nutrition Today, 50(3), 117–128. https://doi.org/10.1097/NT.0000000000000092

Park, Y.-M., Myers, M., & Vieira-Potter, V. J. (2014). Adipose tissue inflammation and metabolic dysfunction: role of exercise. Missouri Medicine, 111(1), 65–72.

Petri, B., & Sanz, M.-J. (2018). Neutrophil chemotaxis. Cell and Tissue Research, 371(3), 425436.https://doi.org/10.1007/s00441-017-2776-8

Prahalnitya, O., & Hendrianingtyas, M. (2021). Correlation of Waist Circumference with Monocyte Lymphocyte Ratio, Hemoglobin, and Hba1c in Obesity. Pakistan Journal of Medical and Health Sciences, 15(7), 2036–2038. https://doi.org/10.53350/pjmhs211572036

Qian, B., Zheng, Y., Jia, H., Zheng, X., Gao, R., & Li, W. (2023). Neutrophil-lymphocyte ratio as a predictive marker for postoperative infectious complications: A systematic review and meta-analysis. Heliyon, 9(5), e15586. https://doi.org/10.1016/j.heliyon.2023.e15586

Sahamastuti, A. A. T., Andre, A., Foustine, S., Sumarpo, A., & Hartiadi, L. Y. (2019). Synergistic Antibacterial Activities of Ginger and Lemongrass Essential Oils as an Alternative Prevention to Food-Borne Disease. Indonesian Journal of Life Sciences | ISSN: 2656-0682 (Online), 1(2), 54–61. https://doi.org/10.54250/ijls.v1i2.25

Supardi, N., Sumarpo, A., Sutejo, R., Putra, A. B. N., Kageyama, N., Kawano, M., & Sugahara, T. (2018). Short Communication: IgE production-suppressing effect of asam kandis (dried Garcinia xantochymus) extracts by mouse hybridoma aDNP-Hy Cells. Biodiversitas Journal of Biological Diversity, 19(1), 330335.https://doi.org/10.13057/biodiv/d190145

Susanto, S., Sumarpo, A., Parikesit, A. A., Putra, A. B. N., Ishida, E., Tabuchi, K., & Sugahara, T. (2018). Short Communication: Immunostimulatory effect of tempoyak (fermented durian) on inducing cytokine production (IL-6 and TNF-α) by RAW 264.7 cells. Biodiversitas Journal of Biological Diversity, 19(1), 318–322. https://doi.org/10.13057/biodiv/d190143




DOI: https://doi.org/10.33024/mahesa.v5i5.17939

Refbacks

  • Saat ini tidak ada refbacks.


Publisher: Universitas Malahayati Lampung


Creative Commons License
Semua artikel dapat digunakan dibawah lisensi Creative Commons Attribution-ShareAlike 4.0 International License


kostenlose besucherzähler