Peran Protektor Vitamin D Dalam Mempertahankan Massa Otot Pada Kelompok Lanjut Usia

Ernawati Ernawati, Frisca Frisca, Alexander Halim Santoso, Edwin Destra, Farell Christian Gunaidi, Alicia Herdiman, Friliesa Averina

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ABSTRACT

 

The increase in the global elderly population increases the risk of sarkopenia, which can reduce activity capacity. Vitamin D deficiency is common in the elderly and plays an important role in musculoskeletal function. This study aims to evaluate the relationship between vitamin D levels and the incidence of sarcopenia in the elderly. This cross-sectional study with a total sampling method involved 93 elderly people aged ≥ 60 years who lived at the Bina Bhakti Nursing Home. Measurements were made on serum vitamin D levels, mid upper arm circumference and calf circumference. Spearman correlation analysis was used to evaluate the relationship between these variables. The results showed that the mean mid upper arm circumference was 23.61 cm (SD = 5.02) with a median of 23 cm, while the mean calf circumference was 28.72 cm (SD = 5.15) with a median of 29 cm. The mean serum vitamin D level was 9.78 ng/mL (SD = 4.47) with a median of 7.5 ng/mL. Spearman correlation analysis showed a significant relationship between mid upper arm circumference and calf circumference (r = 0.572; p < 0.01), upper arm circumference and vitamin D levels (r = 0.254; p = 0.014), and calf circumference and vitamin D levels ( r = 0.218; p = 0.036). This research shows that there is a significant relationship between vitamin D levels and upper arm and calf circumference in the elderly. Vitamin D deficiency is common in the elderly and plays an important role in the prevention and treatment of sarcopenia. Further research is needed to understand the role of vitamin D in preventing muscle loss.

 

Keywords: Calf Circumference, Mid Upper Arm Circumference, Sarkopenia, Vitamin D.

 

 

ABSTRAK

 

Peningkatan populasi lanjut usia global meningkatkan risiko sarkopenia, yang dapat mengurangi kemampuan aktivitas. Kekurangan vitamin D umum terjadi pada lansia dan berperan penting dalam fungsi muskuloskeletal. Penelitian ini bertujuan untuk mengevaluasi hubungan kadar vitamin D dengan kejadian sarkopenia pada lansia. Penelitian ini menggunakan desain potong lintang dengan metode pengambilan sampel total dengan melibatkan 93 lansia berusia ≥ 60 tahun yang tinggal di Panti Werdha Bina Bhakti. Pengukuran dilakukan terhadap kadar vitamin D serum, lingkar lengan atas, dan lingkar betis. Analisis korelasi Spearman digunakan untuk mengevaluasi hubungan antara variabel-variabel tersebut. Hasil penelitian menunjukkan bahwa rerata lingkar lengan atas adalah 23,61 cm (SD = 5,02) dengan median 23 cm, sedangkan rerata lingkar betis adalah 28,72 cm (SD = 5,15) dengan median 29 cm. Rerata kadar vitamin D serum adalah 9,78 ng/mL (SD = 4,47) dengan median 7,5 ng/mL. Analisis korelasi Spearman menunjukkan hubungan signifikan antara lingkar lengan atas dan lingkar betis (r = 0,572; < 0,01), lingkar lengan atas dengan kadar vitamin D (r = 0,254; p = 0,014), serta lingkar betis dengan kadar vitamin D (r = 0,218; p = 0,036). Penelitian ini menunjukkan bahwa terdapat hubungan signifikan antara kadar vitamin D dengan lingkar lengan atas dan betis pada lansia. Kekurangan vitamin D umum terjadi pada lansia dan berperan penting dalam pencegahan dan pengobatan sarkopenia. Penelitian lebih lanjut diperlukan untuk memahami peran vitamin D dalam pencegahan penurunan massa otot.

 

Kata Kunci: Lingkar Betis, Lingkar Lengan Atas, Sarkopenia, Vitamin D.


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Adegbija, O., Hoy, W. E., Dong, B., & Wang, Z. (2017). Body mass index and waist circumference as predictors of all-cause mortality in an Aboriginal Australian community. Obesity Research & Clinical Practice, 11(1), 19–26. https://doi.org/10.1016/j.orcp.2016.06.003

Ardeljan, A. D., & Hurezeanu, R. (2024). Sarkopenia. In StatPearls.

Basrowi, R. W., Rahayu, E. M., Khoe, L. C., Wasito, E., & Sundjaya, T. (2021). The Road to Healthy Ageing: What Has Indonesia Achieved So Far? Nutrients, 13(10), 3441. https://doi.org/10.3390/nu13103441

Cerhan, J. R., Moore, S. C., Jacobs, E. J., Kitahara, C. M., Rosenberg, P. S., Adami, H.-O., Ebbert, J. O., English, D. R., Gapstur, S. M., Giles, G. G., Horn-Ross, P. L., Park, Y., Patel, A. V., Robien, K., Weiderpass, E., Willett, W. C., Wolk, A., Zeleniuch-Jacquotte, A., Hartge, P., … Berrington de Gonzalez, A. (2014). A Pooled Analysis of Waist Circumference and Mortality in 650,000 Adults. Mayo Clinic Proceedings, 89(3), 335–345. https://doi.org/10.1016/j.mayocp.2013.11.011

Chalermsri, C., Aekplakorn, W., & Srinonprasert, V. (2022). Body Mass Index Combined With Possible Sarkopenia Status Is Better Than BMI or Possible Sarkopenia Status Alone for Predicting All-Cause Mortality Among Asian Community-Dwelling Older Adults. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.881121

Cho, M.-R., Lee, S., & Song, S.-K. (2022). A Review of Sarkopenia Pathophysiology, Diagnosis, Treatment and Future Direction. Journal of Korean Medical Science, 37(18), e146. https://doi.org/10.3346/jkms.2022.37.e146

Cook, Z., Kirk, S., Lawrenson, S., & Sandford, S. (2005). Use of BMI in the assessment of undernutrition in older subjects: reflecting on practice. Proceedings of the Nutrition Society, 64(3), 313–317. https://doi.org/10.1079/PNS2005437

Curtis, M., Swan, L., Fox, R., Warters, A., & O’Sullivan, M. (2023). Associations between Body Mass Index and Probable Sarkopenia in Community-Dwelling Older Adults. Nutrients, 15(6), 1505. https://doi.org/10.3390/nu15061505

Di Filippo, L., De Lorenzo, R., Giustina, A., Rovere-Querini, P., & Conte, C. (2022). Vitamin D in Osteosarcopenic Obesity. Nutrients, 14(9), 1816. https://doi.org/10.3390/nu14091816

Dwimartutie, N., Setiati, S., Tamin, T. Z., Prijanti, A. R., Harahap, A. R., Purnamasari, D., Harimurti, K., & Pramantara, I. D. P. (2023). Vitamin D Levels in Pre-frail Older Adults and Its Correlation with Hand Grip Strength. Acta Medica Indonesiana, 55(2), 172–179.

Endo, K., Sato, T., Kakisaka, K., & Takikawa, Y. (2021). Calf and arm circumference as simple markers for screening sarkopenia in patients with chronic liver disease. Hepatology Research, 51(2), 176–189. https://doi.org/10.1111/hepr.13589

Giustina, A., Bouillon, R., Dawson-Hughes, B., Ebeling, P. R., Lazaretti-Castro, M., Lips, P., Marcocci, C., & Bilezikian, J. P. (2022). Vitamin D in the older population: a consensus statement. Endocrine, 79(1), 31–44. https://doi.org/10.1007/s12020-022-03208-3

Goh, K. S., Zhang, D., Png, G. K., Lin, H., Ang, W., Low, S., & Lim, J. (2014). Vitamin D Status in Elderly Inpatients in a Tertiary Hospital in Singapore. Journal of the American Geriatrics Society, 62(7), 1398–1400. https://doi.org/10.1111/jgs.12899

Gu, D. (2006). Body Weight and Mortality Among Men and Women in China. JAMA, 295(7), 776. https://doi.org/10.1001/jama.295.7.776

Gueresi, P., Miglio, R., Cevenini, E., & Gualdi Russo, E. (2014). Arm measurements as determinants of further survival in centenarians. Experimental Gerontology, 58, 230–234. https://doi.org/10.1016/j.exger.2014.08.012

Hou, X., Hu, J., Wang, E., Guo, Q., Zhang, X., Yang, M., Liu, Z., Wang, J., & Song, Z. (2023). The L-shaped association of mid-upper arm circumference with all-cause and cause-specific mortality in US adults: a population-based prospective cohort study. BMC Public Health, 23(1), 2297. https://doi.org/10.1186/s12889-023-17064-x

Hu, F.-J., Liu, H., Liu, X.-L., Jia, S.-L., Hou, L.-S., Xia, X., & Dong, B.-R. (2021). Mid-Upper Arm Circumference as an Alternative Screening Instrument to Appendicular Skeletal Muscle Mass Index for Diagnosing Sarkopenia. Clinical Interventions in Aging, Volume 16, 1095–1104. https://doi.org/10.2147/CIA.S311081

Kemenkes RI. (2018). Riskesdas 2018. In Riset Kesehatan Dasar RI. KEMENKES RI.

Khan, H. T. A. (2019). Population ageing in a globalized world: Risks and dilemmas? Journal of Evaluation in Clinical Practice, 25(5), 754–760. https://doi.org/10.1111/jep.13071

Khan, S., Kumar, S., Acharya, S., & Wanjari, A. (2023). Impact of Vitamin D Level on Sarkopenia in Elderly People: A Critical Review. Journal of Health and Allied Sciences NU, 13(04), 453–458. https://doi.org/10.1055/s-0042-1760090

Kim, M. K., Baek, K. H., Song, K.-H., Il Kang, M., Park, C. Y., Lee, W. Y., & Oh, K. W. (2011). Vitamin D Deficiency Is Associated with Sarkopenia in Older Koreans, Regardless of Obesity: The Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009. The Journal of Clinical Endocrinology & Metabolism, 96(10), 3250–3256. https://doi.org/10.1210/jc.2011-1602

Kim, Y.-H., Kim, S. M., Han, K.-D., Jung, J.-H., Lee, S.-S., Oh, S. W., Park, H. S., Rhee, E.-J., Lee, W.-Y., & Yoo, S. J. (2019). Waist Circumference and All-Cause Mortality Independent of Body Mass Index in Korean Population from the National Health Insurance Health Checkup 2009–2015. Journal of Clinical Medicine, 8(1), 72. https://doi.org/10.3390/jcm8010072

Lin, W., Albu, J., Liu, C., Huang, H., Pi‐Sunyer, F. X., Li, C., Li, T., Lin, C., & Huang, K. (2010). Larger Body Mass Index and Waist Circumference Are Associated with Lower Mortality in Chinese Long‐Term Care Facility Residents. Journal of the American Geriatrics Society, 58(11), 2092–2098. https://doi.org/10.1111/j.1532-5415.2010.03148.x

Mizuno, T., Hosoyama, T., Tomida, M., Yamamoto, Y., Nakamichi, Y., Kato, S., Kawai-Takaishi, M., Ishizuka, S., Nishita, Y., Tange, C., Shimokata, H., Imagama, S., & Otsuka, R. (2022). Influence of vitamin D on sarkopenia pathophysiology: A longitudinal study in humans and basic research in knockout mice. Journal of Cachexia, Sarkopenia and Muscle, 13(6), 2961–2973. https://doi.org/10.1002/jcsm.13102

Mouodi, S., Delbari, S., Hosseini, S. R., Ghadimi, R., & Bijani, A. (2023). Serum Vitamin D Status in Older Adults: A Cohort Study. Iranian Journal of Medical Sciences, 48(3), 277–285. https://doi.org/10.30476/IJMS.2022.94269.2550

National Institute for Health and Care. (2023). Vitamin D - Health Professional Fact Sheet.

Neo, J. J., & Kong, K. H. (2016). Prevalence of Vitamin D Deficiency in Elderly Patients Admitted to an Inpatient Rehabilitation Unit in Tropical Singapore. Rehabilitation Research and Practice, 2016, 1–6. https://doi.org/10.1155/2016/9689760

Park, S., Ham, J.-O., & Lee, B.-K. (2014). A positive association of vitamin D deficiency and sarkopenia in 50 year old women, but not men. Clinical Nutrition, 33(5), 900–905. https://doi.org/10.1016/j.clnu.2013.09.016

Pusparini, N. D., Probosari, E., Murbawani, E. A., Muis, S. F., & Christianto, F. (2022). Diagnostic accuracy of calf circumference for decreased muscle mass in older adults with sarkopenia. Journal of Biomedicine and Translational Research, 1(1), 1–6. https://doi.org/10.14710/jbtr.v1i1.12115

Remelli, F., Vitali, A., Zurlo, A., & Volpato, S. (2019). Vitamin D Deficiency and Sarkopenia in Older Persons. Nutrients, 11(12), 2861. https://doi.org/10.3390/nu11122861

Rose Berlin Piodena-Aportadera, M., Lau, S., Chew, J., Lim, J. P., Ismail, N. H., Ding, Y. Y., & Lim, W. S. (2022). Calf Circumference Measurement Protocols for Sarkopenia Screening: Differences in Agreement, Convergent Validity and Diagnostic Performance. Annals of Geriatric Medicine and Research, 26(3), 215–224. https://doi.org/10.4235/agmr.22.0057

Sayer, A. A., & Cruz-jentoft, A. (2022). Sarkopenia definition , diagnosis and treatment : consensus is growing. 1–5.

Selvaraj, K., Jayalakshmy, R., Yousuf, A., Singh, A., Ramaswamy, G., & Palanivel, C. (2017). Can mid-upper arm circumference and calf circumference be the proxy measures to detect undernutrition among elderly? Findings of a community-based survey in rural Puducherry, India. Journal of Family Medicine and Primary Care, 6(2), 356. https://doi.org/10.4103/jfmpc.jfmpc_357_16

Setiati, S. (2008). Vitamin D status among Indonesian elderly women living in institutionalized care units. Acta Medica Indonesiana, 40(2), 78–83.

Shafiee, G., Keshtkar, A., Soltani, A., Ahadi, Z., Larijani, B., & Heshmat, R. (2017). Prevalence of sarkopenia in the world: a systematic review and meta- analysis of general population studies. Journal of Diabetes & Metabolic Disorders, 16(1), 21. https://doi.org/10.1186/s40200-017-0302-x

Sudarma, V., & Halim, L. (2017). High skeletal muscle mass is associated with increased serum 25(OH)D levels in elderly. Universa Medicina, 36(3), 236–242. https://doi.org/10.18051/UnivMed.2017.v36.236-242

Uchitomi, R., Oyabu, M., & Kamei, Y. (2020). Vitamin D and Sarkopenia: Potential of Vitamin D Supplementation in Sarkopenia Prevention and Treatment. Nutrients, 12(10), 3189. https://doi.org/10.3390/nu12103189

Weng, C.-H., Tien, C.-P., Li, C.-I., L’Heureux, A., Liu, C.-S., Lin, C.-H., Lin, C.-C., Lai, S.-W., Lai, M.-M., & Lin, W.-Y. (2018). Mid-upper arm circumference, calf circumference and mortality in Chinese long-term care facility residents: a prospective cohort study. BMJ Open, 8(5), e020485. https://doi.org/10.1136/bmjopen-2017-020485

WHO. (2022). Ageing and health.

Widajanti, N., Hadi, U., Soebagijo Adi Soelistijo, Noer Halimatus Syakdiyah, Roudhona Rosaudyn, & Hendy Bhaskara Perdana Putra. (2024). The Effect of Vitamin D Supplementation to Parameter of Sarkopenia in Elderly People: a Systematic Review and Meta-Analysis. Canadian Geriatrics Journal, 27(1), 63–75. https://doi.org/10.5770/cgj.27.694

Yang, A., Lv, Q., Chen, F., Wang, Y., Liu, Y., Shi, W., Liu, Y., & Wang, D. (2020). The effect of vitamin D on sarkopenia depends on the level of physical activity in older adults. Journal of Cachexia, Sarkopenia and Muscle, 11(3), 678–689. https://doi.org/10.1002/jcsm.12545




DOI: https://doi.org/10.33024/mahesa.v6i6.20718

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