Correlation between Muscle Strength, Calf Circumference, Vitamin D, and IGF-1 on Depression in the Elderly

Paskalis Andrew Gunawan, Anastasia Ratnawati Biromo, Alexander Halim Santoso, Bryan Anna Wijaya, Kasvana Kasvana, Louise Audrey Sukianto, Yohanes Firmansyah

Sari


ABSTRACT

 

Depression in the elderly is a multifaceted issue influenced by various physiological factors. This study investigates the correlation between muscle strength, calf circumference, Vitamin D, and Insulin-like Growth Factor 1 (IGF-1) levels and their collective impact on depression among the elderly.  This study aims to understand the correlation between muscle strength, calf circumference, Vitamin D, and IGF-1 levels on depression to develop targeted interventions to improve mental health outcomes in this demographic. This cross-sectional study involved 82 older people at RPTRA Krendang. Depression is measured using the Geriatric Depression Scale (GDS). Data were analyzed using Spearman's Rho to see the Correlation between Muscle Strength, Calf Circumference, Vitamin D, and IGF-1 on Depression in the Elderly. The study found most respondents were female (78%), with an average age of 74.34 years, and according to the Geriatric Depression Scale, the majority (59.8%) of respondents were normal. This study highlighted significant correlations between muscle strength, calf circumference, and decreased Vitamin D and IGF-1 levels with higher depression scores. These findings suggest that diminished physical health markers and nutrient deficiencies are associated with increased depressive symptoms in the elderly. Measuring muscle strength, calf circumference, Vitamin D, and IGF-1 levels is a good approach to understanding depression in the elderly that will lead to effective interventions by health workers and improve quality of life.

 

Keywords: Calf Circumference; Depression; IGF-1; Muscle Strength; Vitamin D. 


Referensi


Bąk, E., Młynarska, A., Marcisz, C., Kadłubowska, M., Marcisz-Dyla, E., Sternal, D., Młynarski, R., & Krzemińska, S. (2022). Kinesiophobia In Elderly Polish Patients After Ischemic Stroke, Including Frailty Syndrome. Neuropsychiatric Disease And Treatment. Https://Doi.Org/10.2147/Ndt.S352151

Bakhtiari-Dovvombaygi, H., Izadi, S., Zare Moghaddam, M., Hashemzehi, M., Hosseini, M., Azhdari-Zarmehri, H., Dinpanah, H., & Beheshti, F. (2021). Beneficial Effects Of Vitamin D On Anxiety And Depression-Like Behaviors Induced By Unpredictable Chronic Mild Stress By Suppression Of Brain Oxidative Stress And Neuroinflammation In Rats. Naunyn-Schmiedeberg’s Archives Of Pharmacology, 394(4), 655–667. Https://Doi.Org/10.1007/S00210-020-02002-0

Ceolin, G., Antunes, L. Da C., Moretti, M., Rieger, D. K., & Moreira, J. D. (2023). Vitamin D And Depression In Older Adults: Lessons Learned From Observational And Clinical Studies. Nutrition Research Reviews, 36(2), 259–280. Https://Doi.Org/10.1017/S0954422422000026

Champaiboon, J., Petchlorlian, A., Manasvanich, B., Ubonsutvanich, N., Jitpugdee, W., Kittiskulnam, P., Wongwatthananart, S., Menorngwa, Y., Pornsalnuwat, S., & Praditpornsilpa, K. (2023). Calf Circumference As A Screening Tool For Low Skeletal Muscle Mass: Cut-Off Values In Independent Thai Older Adults. Bmc Geriatrics, 23(1), 826. Https://Doi.Org/10.1186/S12877-023-04543-4

Chigogora, S., Zaninotto, P., Kivimaki, M., Steptoe, A., & Batty, G. D. (2016). Insulin-Like Growth Factor 1 And Risk Of Depression In Older People: The English Longitudinal Study Of Ageing. Translational Psychiatry, 6(9), E898–E898. Https://Doi.Org/10.1038/Tp.2016.167

Cordeiro, R. C., Santos, R. C. Dos, Araújo, G. K. N. De, Nascimento, N. De M., Souto, R. Q., Ceballos, A. G. Da C. De, Alves, F. A. P., & Santos, J. (2020). Mental Health Profile Of The Elderly Community: A Cross-Sectional Study. Revista Brasileira De Enfermagem. Https://Doi.Org/10.1590/0034-7167-2018-0191

Danese, A., & J Lewis, S. (2017). Psychoneuroimmunology Of Early-Life Stress: The Hidden Wounds Of Childhood Trauma? Neuropsychopharmacology, 42(1), 99–114. Https://Doi.Org/10.1038/Npp.2016.198

Ganipineni, V. D. P., Idavalapati, A. S. K. K., Tamalapakula, S. S., Moparthi, V., Potru, M., & Owolabi, O. J. (2023). Depression And Hand-Grip: Unraveling The Association. Cureus. Https://Doi.Org/10.7759/Cureus.38632

Gao, K., Ma, W.-Z., Huck, S., Li, B.-L., Zhang, L., Zhu, J., Li, T., & Zhou, D. (2021). Association Between Sarcopenia And Depressive Symptoms In Chinese Older Adults: Evidence From The China Health And Retirement Longitudinal Study. Frontiers In Medicine, 8. Https://Doi.Org/10.3389/Fmed.2021.755705

Giri, M., Chen, T., Yu, W., & Lü, Y. (2016). Prevalence And Correlates Of Cognitive Impairment And Depression Among Elderly People In The World&Rsquo;S Fastest Growing City, Chongqing, People&Rsquo;S Republic Of China. Clinical Interventions In Aging, Volume 11, 1091–1098. Https://Doi.Org/10.2147/Cia.S113668

Grozić, A., Coker, K., Dussik, C. M., Sabir, M. S., Sabir, Z., Bradley, A., Zhang, L., Park, J., Yale, S., Kaneko, I., Hockley, M., Harris, L. A., Lunsford, T. N., Sandrin, T. R., & Jurutka, P. W. (2022). Identification Of Putative Transcriptomic Biomarkers In Irritable Bowel Syndrome (Ibs): Differential Gene Expression And Regulation Of Tph1 And Sert By Vitamin D. Plos One, 17(10), E0275683. Https://Doi.Org/10.1371/Journal.Pone.0275683

Güney, İ., Biyik, M., Yeksan, M., Biyik, Z., Atalay, H., Solak, Y., Selçuk, N. Y., Tonbul, H. Z., & Türk, S. (2008). Sleep Quality And Depression In Peritoneal Dialysis Patients. Renal Failure. Https://Doi.Org/10.1080/08860220802406419

Holick, M. F., Mazzei, L., García Menéndez, S., Martín Giménez, V. M., Al Anouti, F., & Manucha, W. (2023). Genomic Or Non-Genomic? A Question About The Pleiotropic Roles Of Vitamin D In Inflammatory-Based Diseases. Nutrients, 15(3), 767. Https://Doi.Org/10.3390/Nu15030767

Idaiani, S., & Indrawati, L. (2021). Functional Status In Relation To Depression Among Elderly Individuals In Indonesia: A Cross-Sectional Analysis Of The Indonesian National Health Survey 2018 Among Elderly Individuals. Bmc Public Health, 21(1), 2332. Https://Doi.Org/10.1186/S12889-021-12260-Z

Jin, B., Zhang, H., Song, F., Wu, G., & Ye, H. (2022). Interaction Of Sleep Duration And Depression On Cardiovascular Disease: A Retrospective Cohort Study. Bmc Public Health. Https://Doi.Org/10.1186/S12889-022-14143-3

Khanal, G., Selvamani, Y., Thapa, S., & Chinnaiyan, S. (2024). Prevalence And Covariates Of Depression Among Older Adults In Nepal: A Systematic Review And Meta-Analysis. Plos Mental Health, 1(4), E0000112. Https://Doi.Org/10.1371/Journal.Pmen.0000112

Kim, H. A., Perrelli, A., Ragni, A., Retta, F., De Silva, T. M., Sobey, C. G., & Retta, S. F. (2020). Vitamin D Deficiency And The Risk Of Cerebrovascular Disease. Antioxidants, 9(4), 327. Https://Doi.Org/10.3390/Antiox9040327

Kim, K. W., Yoon, I.-Y., Chung, S., Shin, Y., Lee, S. B., Choi, E. A., Park, J. H., & Kim, J. M. (2010). Prevalence, Comorbidities And Risk Factors Of Restless Legs Syndrome In The Korean Elderly Population – Results From The Korean Longitudinal Study On Health And Aging. Journal Of Sleep Research. Https://Doi.Org/10.1111/J.1365-2869.2009.00739.X

Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. Il, Thompson, W., Kirkland, J. L., & Sandri, M. (2019). Sarcopenia: Aging-Related Loss Of Muscle Mass And Function. Physiological Reviews, 99(1), 427–511. Https://Doi.Org/10.1152/Physrev.00061.2017

Levada, O. A., & Troyan, A. S. (2017). Insulin-Like Growth Factor-1: A Possible Marker For Emotional And Cognitive Disturbances, And Treatment Effectiveness In Major Depressive Disorder. Annals Of General Psychiatry, 16(1), 38. Https://Doi.Org/10.1186/S12991-017-0161-3

Liu, J., Liu, Y., Ma, W., Tong, Y., & Zheng, J. (2024). Temporal And Spatial Trend Analysis Of All-Cause Depression Burden Based On Global Burden Of Disease (Gbd) 2019 Study. Scientific Reports, 14(1), 12346. Https://Doi.Org/10.1038/S41598-024-62381-9

Maier, A., Riedel-Heller, S. G., Pabst, A., & Luppa, M. (2021). Risk Factors And Protective Factors Of Depression In Older People 65+. A Systematic Review. Plos One, 16(5), E0251326. Https://Doi.Org/10.1371/Journal.Pone.0251326

Malhi, G. S., & Mann, J. J. (2018). Depression. The Lancet, 392(10161), 2299–2312. Https://Doi.Org/10.1016/S0140-6736(18)31948-2

Marques, A., Gomez-Baya, D., Peralta, M., Frasquilho, D., Santos, T., Martins, J., Ferrari, G., & Gaspar De Matos, M. (2020). The Effect Of Muscular Strength On Depression Symptoms In Adults: A Systematic Review And Meta-Analysis. International Journal Of Environmental Research And Public Health, 17(16), 5674. Https://Doi.Org/10.3390/Ijerph17165674

Monk, T. H., Pfoff, M. K., & Zarotney, J. R. (2013). Depression In The Spousally Bereaved Elderly: Correlations With Subjective Sleep Measures. Depression Research And Treatment. Https://Doi.Org/10.1155/2013/409538

Obuobi-Donkor, G., Nkire, N., & Agyapong, V. I. O. (2021). Prevalence Of Major Depressive Disorder And Correlates Of Thoughts Of Death, Suicidal Behaviour, And Death By Suicide In The Geriatric Population—A General Review Of Literature. Behavioral Sciences, 11(11), 142. Https://Doi.Org/10.3390/Bs11110142

Okereke, O. I., & Singh, A. (2016). The Role Of Vitamin D In The Prevention Of Late-Life Depression. Journal Of Affective Disorders, 198, 1–14. Https://Doi.Org/10.1016/J.Jad.2016.03.022

Qiao, X., Yan, J., Zang, Z., Xi, L., Zhu, W., Zhang, E., & Wu, L. (2024). Association Between Igf-1 Levels And Mdd: A Case-Control And Meta-Analysis. Frontiers In Psychiatry, 15. Https://Doi.Org/10.3389/Fpsyt.2024.1396938

Remes, O., Mendes, J. F., & Templeton, P. (2021). Biological, Psychological, And Social Determinants Of Depression: A Review Of Recent Literature. Brain Sciences, 11(12), 1633. Https://Doi.Org/10.3390/Brainsci11121633

Sabir, Z. L., Livingston, S., Whitfield, G. K., Haussler, M. R., & Jurutka, P. (2020). Vitamin D Impacts Nrf‐2 Signaling And Antioxidation Pathways That Modulate Cellular Aging. The Faseb Journal, 34(S1), 1–1. Https://Doi.Org/10.1096/Fasebj.2020.34.S1.09913

Santoso, A. H., Lontoh, S. O., Firmansyah, Y., Yogie, G. S., Goh, D., Syarifah, A. G., Teguh, S. K. M. M., & Khoto, A. E. P. (2024). Hubungan Kadar 25(Oh)D3 Dengan Lingkar Betis Pada Kelompok Lanjut Usia Di Panti Santa Anna: Studi Potong-Lintang. Malahayati Nursing Journal, 6(7), 2583–2591. Https://Doi.Org/10.33024/Mnj.V6i7.13124

Sepehrmanesh, Z., Kolahdooz, F., Abedi, F., Mazroii, N., Assarian, A., Asemi, Z., & Esmaillzadeh, A. (2016). Retracted: Vitamin D Supplementation Affects The Beck Depression Inventory, Insulin Resistance, And Biomarkers Of Oxidative Stress In Patients With Major Depressive Disorder: A Randomized, Controlled Clinical Trial. The Journal Of Nutrition, 146(2), 243–248. Https://Doi.Org/10.3945/Jn.115.218883

Smith, L., White, S., Stubbs, B., Hu, L., Veronese, N., Vancampfort, D., Hamer, M., Gardner, B., & Yang, L. (2018). Depressive Symptoms, Handgrip Strength, And Weight Status In Us Older Adults. Journal Of Affective Disorders, 238, 305–310. Https://Doi.Org/10.1016/J.Jad.2018.06.016

Susy Olivia, Alexander Halim Santoso, Alicia Herdiman, Yovian Timothy Satyo, Farell Christian Gunaidi, & Edwin Destra. (2024). Kegiatan Penapisan Kesehatan Mental Mengenai Depresi Pada Kelompok Lanjut Usia. Kreatif: Jurnal Pengabdian Masyarakat Nusantara, 4(2), 87–93. Https://Doi.Org/10.55606/Kreatif.V4i2.3380

Tan, J.-Y., Zeng, Q.-L., Ni, M., Zhang, Y.-X., & Qiu, T. (2022). Association Among Calf Circumference, Physical Performance, And Depression In The Elderly Chinese Population: A Cross-Sectional Study. Bmc Psychiatry, 22(1), 278. Https://Doi.Org/10.1186/S12888-022-03925-Z

Jin, B., Zhang, H., Song, F., Wu, G., & Ye, H. (2022). Interaction Of Sleep Duration And Depression On Cardiovascular Disease: A Retrospective Cohort Study. Bmc Public Health. Https://Doi.Org/10.1186/S12889-022-14143-3

Kim, K. W., Yoon, I.-Y., Chung, S., Shin, Y., Lee, S. B., Choi, E. A., Park, J. H., & Kim, J. M. (2010). Prevalence, Comorbidities And Risk Factors Of Restless Legs Syndrome In The Korean Elderly Population – Results From The Korean Longitudinal Study On Health And Aging. Journal Of Sleep Research. Https://Doi.Org/10.1111/J.1365-2869.2009.00739.X

Monk, T. H., Pfoff, M. K., & Zarotney, J. R. (2013). Depression In The Spousally Bereaved Elderly: Correlations With Subjective Sleep Measures. Depression Research And Treatment. Https://Doi.Org/10.1155/2013/409538

Tsaras, K., Tsiantoula, M., Papathanasiou, I. V, Papagiannis, D., Chatzi, M., & Fradelos, Ε. C. (2021). Predictors Of Depression And Insomnia In Community-Dwelling Elderly People: A Cross-Sectional Evidence Of Their Bidirectional Relationship. Cureus. Https://Doi.Org/10.7759/Cureus.13965

Yap, A. F., Kwan, Y. H., Tan, C. S., Ibrahim, S., & Ang, S. Bin. (2017). Rhythm-Centred Music Making In Community Living Elderly: A Randomized Pilot Study. Bmc Complementary And Alternative Medicine. Https://Doi.Org/10.1186/S12906-017-1825-X

Yu, A.-L., Lo, S., Chen, P.-Y., & Lu, S.-F. (2022). Effects Of Group Music Intervention On Depression For Elderly People In Nursing Homes. International Journal Of Environmental Research And Public Health. Https://Doi.Org/10.3390/Ijerph19159291

Zhang, Y., & Tian, Y. (2022). The Relationship Between Physical Activity And Depressive Symptoms In Middle-Aged And Elderly People Controlling For Demographic And Health Status Variables. Sustainability. Https://Doi.Org/10.3390/Su142113986




DOI: https://doi.org/10.33024/mahesa.v6i5.22435

Refbacks

  • Saat ini tidak ada refbacks.


Publisher: Universitas Malahayati Lampung

Creative Commons License
Semua artikel dapat digunakan dibawah lisensi Creative Commons Attribution-ShareAlike 4.0 International License