Vaping dan Kesehatan Paru dalam Perspektif Medis: Risiko dan Implikasi Jangka Panjang

Nadya Nur Syafina Putri, Maritza Adelia Putri, Rizky Khaeran, Bagas Gunanto, Januar Ariyanto

Abstract


Penggunaan rokok elektrik (vape) terus meningkat, terutama di kalangan remaja dan dewasa muda, karena dianggap sebagai alternatif yang lebih aman dibandingkan rokok konvensional. Penelitian ini bertujuan untuk meninjau secara komprehensif dampak penggunaan vape terhadap kesehatan paru-paru dalam jangka panjang. Metode yang digunakan adalah tinjauan pustaka dengan mengkaji berbagai artikel ilmiah dari database seperti PubMed, ScienceDirect, dan lainnya dalam rentang tahun 2020–2025. Hasil analisis menunjukkan bahwa penggunaan vape dapat menyebabkan berbagai gangguan pernapasan, termasuk inflamasi paru, gangguan fungsi paru, dan potensi kanker paru. Kandungan dalam cairan vape seperti formaldehida, logam berat, dan vitamin E asetat berkontribusi terhadap kerusakan jaringan paru dan sistem kardiovaskular. Beberapa studi juga melaporkan kasus EVALI (e-cigarette or vaping-associated lung injury) dengan gejala serius dan risiko kematian. Selain itu, tantangan besar dalam terapi berhenti vaping, terutama pada remaja, memperkuat perlunya pendekatan kebijakan dan klinis berbasis bukti yang lebih kuat. Simpulan dari kajian ini adalah bahwa vaping bukanlah alternatif yang aman dan justru membawa dampak buruk bagi kesehatan paru secara signifikan.


Keywords


Vaping; kesehatan paru; EVALI; risiko jangka panjang

Full Text:

PDF

References


Aberegg, S. K., Cirulis, M. M., Maddock, S. D., Freeman, A., Keenan, L. M., Pirozzi, C. S., Raman, S. M., Schroeder, J., Mann, H., & Callahan, S. J. (2020). Clinical, Bronchoscopic, and Imaging Findings of e-Cigarette, or Vaping, Product Use-Associated Lung Injury among Patients Treated at an Academic Medical Center. JAMA Network Open, 3(11). https://doi.org/10.1001/jamanetworkopen.2020.19176

Adams, Z. W., Kwon, E., Aalsma, M. C., Zapolski, T. C. B., Dir, A., & Hulvershorn, L. A. (2021). Treatment of Adolescent e-Cigarette Use: Limitations of Existing Nicotine Use Disorder Treatment and Future Directions for e-Cigarette Use Cessation. In Journal of the American Academy of Child and Adolescent Psychiatry (Vol. 60, Issue 1, pp. 14–16). Elsevier Inc. https://doi.org/10.1016/j.jaac.2020.07.007

Aldy, K., Cao, D. J., Weaver, M. M., Rao, D., & Feng, S. Y. (2020). E-cigarette or vaping product use-associated lung injury (EVALI) features and recognition in the emergency department. In JACEP Open (Vol. 1, Issue 5, pp. 1090–1096). John Wiley and Sons Inc. https://doi.org/10.1002/emp2.12112

Becker, T. D., & Rice, T. R. (2022). Youth vaping: a review and update on global epidemiology, physical and behavioral health risks, and clinical considerations. In European Journal of Pediatrics (Vol. 181, Issue 2, pp. 453–462). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/s00431-021-04220-x

Bittoni M, Carbone D, & Harris R. (2024). Vaping, Smoking and Lung Cancer Risk. Journal of Oncology Research and Therapy, 9(3). https://doi.org/10.29011/2574-710x.10229

Blagev, D. P., Callahan, S. J., Harris, D., Collingridge, D. S., Hopkins, R. O., Eve, J. R., Waddoups, L., Aston, V., Brown, S., & Lanspa, M. J. (2022). Prospectively Assessed Long-Term Outcomes of Patients with E-Cigarette- or Vaping-associated Lung Injury. Annals of the American Thoracic Society, 19(11), 1892–1899. https://doi.org/10.1513/AnnalsATS.202201-049OC

Buettner-Schmidt K, Schaeffer Fraase K, Barnacle M, Peltier A, Saarinen H, Brody M, & Turrubiates N. (2024). A review of vaping’s health eff ects, treatment, and policy implications: Nursing’s call to action (Vol. 49, Issue 9). www.tnpj.com

Burrowes, K. S., Seal, M., Noorababaee, L., Pontré, B., Dubowitz, D., Sá, R. C., & Prisk, G. K. (2024). Vaping causes an acute BMI-dependent change in pulmonary blood flow. Physiological Reports, 12(20), e70094. https://doi.org/10.14814/phy2.70094

Chun, L. F., Moazed, F., Calfee, C. S., Matthay, M. A., & Gotts, J. E. (2017). Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol, 313, 193–206. https://doi.org/10.1152/ajplung.00071.2017.-Electronic

Constantin, A. A., & Mihălțan, F. D. (2025). E-Cigarette and Environment. In Environments - MDPI (Vol. 12, Issue 3). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/environments12030072

Dai, Y., Yang, W., Song, H., He, X., Guan, R., Wu, Z., Jiang, X., Li, M., Liu, P., & Chen, J. (2024). Long-term effects of chronic exposure to electronic cigarette aerosol on the cardiovascular and pulmonary system in mice: A comparative study to cigarette smoke. Environment International, 185. https://doi.org/10.1016/j.envint.2024.108521

Etter, J. F. (2024). An 8-year longitudinal study of long-term, continuous users of electronic cigarettes. Addictive Behaviors, 149. https://doi.org/10.1016/j.addbeh.2023.107891

Gotts E, Jordt S, McConnell R, & Tarran R. (2019). What are the respiratory effects of e-cigarettes? BMJ.

Jebur, H. B., Bahlok Jebur, H., Abd, B., Al Saray, A.-K., Ikareim Idbeis, H., Akhter, J., Afzal, S. M., Khan, N., Abdelsalam, K. G., Qadim, W. Q., & Muhaisen, A. (2023). Bulletin of Pharmaceutical Sciences LUNG HISTO-PATHOLOGICAL CHANGES AND SODS GENE EXPRESSION IN WISTER RATS EXPOSED TO CONVENTIONAL AND ELECTRONIC CIGARETTES. In Bull. Pharm. Sci., Assiut University (Vol. 46, Issue 102). http://bpsa.journals.ekb.eg/

Jin, L., Lynch, J., Richardson, A., Lorkiewicz, P., Srivastava, S., Theis, W., Shirk, G., Hand, A., Bhatnagar, A., Srivastava, S., & Conklin, D. J. (2021). Electronic cigarette solvents, pulmonary irritation, and endothelial dysfunction: role of acetaldehyde and formaldehyde. American Journal of Physiology - Heart and Circulatory Physiology, 320(4), H1510–H1525. https://doi.org/10.1152/AJPHEART.00878.2020

Kabéle, M., Lyytinen, G., Bosson, J. A., Hedman, L., Antoniewicz, L., Lundbäck, M., & Mobarrez, F. (2025). Nicotine in E-cigarette aerosol may lead to pulmonary inflammation. Respiratory Medicine, 242. https://doi.org/10.1016/j.rmed.2025.108101

Layden, J. E., Ghinai, I., Pray, I., Kimball, A., Layer, M., Tenforde, M. W., Navon, L., Hoots, B., Salvatore, P. P., Elderbrook, M., Haupt, T., Kanne, J., Patel, M. T., Saathoff-Huber, L., King, B. A., Schier, J. G., Mikosz, C. A., & Meiman, J. (2020). Pulmonary Illness Related to E-Cigarette Use in Illinois and Wisconsin — Final Report. New England Journal of Medicine, 382(10), 903–916. https://doi.org/10.1056/nejmoa1911614

Martin, A., Tempra, C., Yu, Y., Liekkinen, J., Thakker, R., Lee, H., de Santos Moreno, B., Vattulainen, I., Rossios, C., Javanainen, M., & Bernardino de la Serna, J. (2024). Exposure to Aldehyde Cherry e-Liquid Flavoring and Its Vaping Byproduct Disrupt Pulmonary Surfactant Biophysical Function. Environmental Science and Technology, 58(3), 1495–1508. https://doi.org/10.1021/acs.est.3c07874

Masso-Silva, J. A., Byun, M. K., & Crotty Alexander, L. E. (2021). Acute and chronic effects of vaping electronic devices on lung physiology and inflammation. In Current Opinion in Physiology (Vol. 22). Elsevier Ltd. https://doi.org/10.1016/j.cophys.2021.06.001

Peruzzi, M., Cavarretta, E., Frati, G., Carnevale, R., Miraldi, F., Biondi-Zoccai, G., Sciarretta, S., Versaci, F., Cammalleri, V., Avino, P., Protano, C., & Vitali, M. (2020). Comparative indoor pollution from glo, iqos, and juul, using traditional combustion cigarettes as benchmark: Evidence from the randomized sur-vapes air trial. International Journal of Environmental Research and Public Health, 17(17), 1–13. https://doi.org/10.3390/ijerph17176029

Pisinger, C., & Bergman Rasmussen, S. K. (2022). Real-World Dual Use of Electronic and Conventional Cigarettes versus the Health Effects of Exclusive Smoking of Conventional Cigarettes: A Systematic Review The Health Effects of Real-World Dual Use of Electronic and Conventional Cigarettes versus the Health Effects of Exclusive Smoking of Conventional Cigarettes: A Systematic Review. Int. J. Environ. Res. Public Health, 19, 13687. https://doi.org/10.3390/ijerph

Rachid, C., Fikri, O., & Amro, L. (2023). E-cigarette and Vaping-Induced Lung Injury (EVALI) Long Taken for Miliary Tuberculosis: A Rare Cause of Interstitial Lung Disease. Cureus. https://doi.org/10.7759/cureus.47948

Shehata, S. A., Toraih, E. A., Ismail, E. A., Hagras, A. M., Elmorsy, E., & Fawzy, M. S. (2023). Vaping, Environmental Toxicants Exposure, and Lung Cancer Risk. In Cancers (Vol. 15, Issue 18). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/cancers15184525

Sobczak, A., Kośmider, L., Koszowski, B., & Goniewicz, M. (2020). E-cigarettes and their impact on health: From pharmacology to clinical implications. In Polish Archives of Internal Medicine (Vol. 130, Issues 7–8, pp. 668–675). Medycyna Praktyczna Cholerzyn. https://doi.org/10.20452/pamw.15229

Tannert Niang, K. M., Grasso, A. B., Debchoudhury, I., Bushman, D., Jasek, J. P., Fairclough, M. A., Van Oss, K. R., Chamany, S., LaSane, K. D., Franklin, S. M., & Talati, A. K. (2025). Prospective follow-up of New York City residents with e-cigarette, or vaping product use-associated lung injury—2020–2021. PLOS One, 20(4), e0304918. https://doi.org/10.1371/journal.pone.0304918

Triantafyllou, G. A., Tiberio, P. J., Zou, R. H., Lynch, M. J., Kreit, J. W., McVerry, B. J., Morris, A., & Rose, J. J. (2021). Long-term outcomes of EVALI: a 1-year retrospective study. In The Lancet Respiratory Medicine (Vol. 9, Issue 12, pp. e112–e113). Elsevier Ltd. https://doi.org/10.1016/S2213-2600(21)00415-X

World Health Organization. (2021). WHO REPORT ON THE GLOBAL TOBACCO EPIDEMIC, 2021 Addressing new and emerging products fresh and alive. https://www.who.int/publications/i/item/9789240032095

World Health Organization. (2023). Global Adult Tobacco Survey (GATS) Indonesia report 2021. Country Office for Indonesia. https://iris.who.int/handle/10665/378343




DOI: https://doi.org/10.33024/jdk.v15i1.21396

Refbacks

  • There are currently no refbacks.


Copyright (c) 2026 Jurnal Dunia Kesmas

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Published by:
Persatuan Dosen Kesehatan Masyarakat

Editorial Address:
Jl. Pramuka No. 27 Kemiling Bandar Lampung Cq. Tim Jurnal Dunia Kesmas.
Whatsapp : 0822-8154-6379 (admin)