Laporan Kasus Toksoplasmosis Serebri Pada Pasien HIV
Sari
Infeksi susunan saraf pusat pada pasien HIV sering disebabkan oleh toksoplasmosis serebral, yaitu infeksi intrakranial oportunistik yang disebabkan oleh parasit Toxoplasma gondii. Pasien laki-laki mengeluh pandangan mata kabur, berbayang dan penglihatan terbatas sejak 1 bulan yang lalu. Pasien juga merasakan kedua matanya menjadi juling, nyeri kepala, demam hilang timbul tidak terlalu tinggi, dan pernah kejang. Pasien didiagnosis HIV sejak 2 bulan yang lalu dan sudah mengonsumsi obat ARV. Pada pemeriksaan fisik didapatkan lidah, mukosa rongga mulut, dan palatum ditemukan kandidiasis oral. Pemeriksaan saraf kranial didapatkan lipatan nasolabial tidak simetris, deviasi lidah ke kiri, wajah kesan tertarik ke sisi kiri dan sisi kanan tertinggal, didapatkan strabismus ke arah medial, dan lapang pandang sebelah kiri terganggu. Hasil pemeriksaan anti-Toxoplasma IgG positif. Hasil pemeriksaan CT-scan kepala dengan kontras menunjukkan lesi hipodens di lobus parietalis sinistra, meninges tampak enhanced fokal sugestif meningoencephalitis focal dan oedema cerebri. Pasien didiagnosis toksoplasmosis serebri berdasarkan gejala klinis, pencitraan, dan adanya IgG anti-T. gondii. Pasien diberikan cairan rumatan; obat-obatan simtomatis berupa injeksi phenytoin untuk profilaksis kejang, injeksi ranitidin, parasetamol, dan vitamin B6; dan obat-obatan kausatif seperti clindamycin, nystatin, kotrimoksazol, isoniazid, serta melanjutkan konsumsi ARV.
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Ayoade, F., & Chandranesan, A. (2022). HIV-1 Associated Toxoplasmosis. Treasure Island: Stat Pearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK441877/. (Accessed: 20 Februari 2024)
Azovtseva, O. V., Viktorova, E. A., Bakulina, C. G., Shelomov, A. S., & Trofimova, T. N. (2020). Cerebral toxoplasmosis in HIV-infected patients over 2015-2018 (a case study of Russia). Epidemiology and Infection, 148(e142), 1-6.
Basavaraju, A. (2016). Toxoplasmosis in HIV infection: An overview. Tropical Parasitology, 6(2), 129-135.
CDC. (2024). Clinical Care of Toxoplasmosis. Available at: https://www.cdc.gov/toxoplasmosis/hcp/clinical-care/index.html. (Accessed: 2 September 2024)
Dian, S., Ganiem, A. R., & Ekawardhani, S. (2023). Cerebral toxoplasmosis in HIV-infected patients: a review. In Pathogens and Global Health, 117(1), 14–23.
Dunay, I. R., Gajurel, K., Dhakal, R., Liesenfeld, O., & Montoya, J. G. (2018). Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice. Clinical Microbiology Reviews, 31(4), 1-33.
Fitriyani, Puspa, D. P., Wahyu, J. R., (2023). Diagnosis dan tatalaksana epilepsi. Medula, 13(6), 941-944.
Gupta, M., & Tripp, J. (2024). Phenytoin. Treasure Island: Stat Pearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK551520/. (Accessed: 2 September 2024)
Hidayati, H., & Kustriyani, A. (2020). Paracetamol, Migraine, And Medication Overuse Headache (MOH). Journal of Pain, Vertigo and Headache, 1(2), 42–47.
Imran, D., Estiasari, R., Maharani, K., Sucipto, Lestari, D. C., Yunus, R. E., Yunihastuti, E., Karyadi, T. H., Oei, D., Timan, I. S., Wulandari, D., Wahyuningsih, R., Adawiyah, R., Kurniawan, A., Mulyadi, R., Karuniawati, A., Jaya, U. A., Safari, D., Van Laarhoven, A., … Van Crevel, R. (2018). Presentation, etiology, and outcome of brain infections in an Indonesian hospital: A cohort study. Neurology: Clinical Practice, 8(5), 379–388.
Kemenkes RI. (2019). Keputusan Menteri Kesehatan Republik Indonesia Tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana HIV HK.01.07/MENKES/90/2019. Jakarta: Kemenkes RI
Kumar, A., Ighodaro, E., & Sharma, S. (2024). Focal Impaired Awareness Seizure. Treasure Island: Stat Pearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK519030/. (Accessed: 2 September 2024)
Lakoh, S., Jiba, D. F., Kanu, J. E., Poveda, E., Salgado-Barreira, A., Sahr, F., Sesay, M., Deen, G. F., Sesay, T., Gashau, W., Salata, R. A., & Yendewa, G. A. (2019). Causes of hospitalization and predictors of HIV-associated mortality at the main referral hospital in Sierra Leone: A prospective study. BMC Public Health, 19(1), 1-9.
Lefta, Y., Arafat, R., & Syahrul, S. (2021). The influence of oral hygiene education on the oral health status of patients suffering from HIV/AIDS. In Indonesian Contemporary Nursing Journal, 5(2), 68-78.
Liwang, F., Wijaya, E., Yuswar, P. W., & Sanjaya, N. P. (2020). Kapita Selekta Kedokteran Jilid I (5th ed.). Depok: Media Aesculapius
McFarland, M., Bartlett, M., & Davis, P. (2016). Toxoplasmic Encephalitis. In Encephalitis. 1st Edition. Berlin: AvidScience. 1-52. Available at: https://www.researchgate.net/publication/307970459.
Munir, B., Husna, M., Santoso, W., Kurniawan, S., & Rahayu, M. (2014). Continuing Neurology Education. Malang: Brawijaya University Press
Nacher, M., Adenis, A., Guarmit, B., Lucarelli, A., Blanchet, D., Demar, M., Djossou, F., Abboud, P., Epelboin, L., & Couppié, P. (2020). What is AIDS in the Amazon and the Guianas in the 90-90-90 era? In PLoS ONE, 15(7), 1-7.
Pacheco, P. R. G., Zara, A. L. S. A., Silva E Souza, L. C., & Turchi, M. D. (2019). Late onset of antiretroviral therapy in adults living with HIV in an urban area in Brazil: Prevalence and risk factors. Journal of Tropical Medicine, 2019(1), 1-8.
Rai, A., Misra, S. R., Panda, S., Sokolowski, G., Mishra, L., Das, R., & Lapinska, B. (2022). Nystatin effectiveness in oral candidiasis treatment: A systematic review & meta-analysis of clinical trials. In Life, 12(11). MDPI. 1-16.
Rusjdi, S. R. (2020). Respon imun terhadap infeksi Toxoplasma gondii. In Jurnal Kesehatan Andalas, 9(1), 100-107.
Safarpour, H., Cevik, M., Zarean, M., Barac, A., Hatam-Nahavandi, K., Rahimi, M. T., Bannazadeh Baghi, H., Koshki, T. J., Pagheh, A. S., Shahrivar, F., Ebrahimi, M., & Ahmadpour, E. (2020). Global status of Toxoplasma gondii infection and associated risk factors in people living with HIV. AIDS, 34(3), 469–474.
Sahu, A. C., & Akhade, K. S. (2022). A cross-sectional study on stigma and discrimination confronted by HIV positive patients in the economic capital of India. Journal of Family Medicine and Primary Care, 11(7), 3622–3627.
Seo, H. H., Han, H. W., Lee, S. E., Hong, S. H., Cho, S. H., Kim, S. C., Koo, S. K., & Kim, J. H. (2020). Modelling Toxoplasma gondii infection in human cerebral organoids. Emerging Microbes and Infections, 9(1), 1943–1954.
Telles, J. P., Fernandes, R., Barros, T. D., Maestri, A., Vitoriano, T., Borges, L., Teixeira, R., Marcusso, R., Haziot, M., De Oliveira, A. P., & Vidal, J. E. (2021). Neurological manifestations in people living with HIV/AIDS in the late cART era: a prospective observational study at a tertiary healthcare center in São Paulo, Brazil. HIV Research and Clinical Practice, 22(4), 87–95.
Vidal, J. E. (2019). HIV-related cerebral toxoplasmosis revisited: Current concepts and controversies of an old disease. In Journal of the International Association of Providers of AIDS Care, Vol. 18, 1-20.
Wang, H., Zhang, Q., Shi, Y., Li, R., Wang, S., Sun, J., Xia, S., & Li, H. (2020). The imaging diagnostic criteria of AIDS-related cerebral toxoplasmosis in China. Radiology of Infectious Diseases, 7(3), 85–90.
Wang, Z. D., Wang, S. C., Liu, H. H., Ma, H. Y., Li, Z. Y., Wei, F., Zhu, X. Q., & Liu, Q. (2017). Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: a systematic review and meta-analysis. The Lancet HIV, 4(4), e177–e188.
WHO. (2024). HIV and AIDS. Available at: Https://www.Who.Int/News-Room/Fact-Sheets/Detail/Hiv-Aids.
Vidal, J. E. (2019). HIV-Related Cerebral Toxoplasmosis Revisited: Current Concepts and Controversies of an Old Disease. In Journal of the International Association of Providers of AIDS Care (Vol. 18). SAGE Publications Inc. https://doi.org/10.1177/2325958219867315
Wang, H., Zhang, Q., Shi, Y., Li, R., Wang, S., Sun, J., Xia, S., & Li, H. (2020). The imaging diagnostic criteria of AIDS-related cerebral toxoplasmosis in China. Radiology of Infectious Diseases, 7(3), 85–90. https://doi.org/10.1016/j.jrid.2020.08.003
Wang, Z. D., Wang, S. C., Liu, H. H., Ma, H. Y., Li, Z. Y., Wei, F., Zhu, X. Q., & Liu, Q. (2017). Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: a systematic review and meta-analysis. The Lancet HIV, 4(4), e177–e188. https://doi.org/10.1016/S2352-3018(17)30005-X
WHO. (2024, July 22). HIV and AIDS. Https://Www.Who.Int/News-Room/Fact-Sheets/Detail/Hiv-Aids.
DOI: https://doi.org/10.33024/jikk.v11i11.17470
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