Hubungan Faktor Risiko Osteoartritis Dengan Derajat Manifestasi Klinis Osteoartritis Sendi Lutut Di Rumah Sakit Kota Samarinda

Grace Steffany Silitonga, Danial Danial, Gregorius Tekwan

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Osteoartritis (OA) adalah penyakit sendi non-inflamasi yang bersifat degeneratif kronis. Sebanyak ±528 juta orang di dunia menderita OA pada tahun 2019. Berbagai kombinasi faktor risiko dapat memengaruhi OA dan perkembangannya pada tiap individu. OA pada sendi besar, yaitu sendi lutut dan pinggul, menimbulkan disabilitas yang lebih buruk dan beban penyakit yang lebih signifikan. OA pada sendi lutut menyebabkan tahun hidup dengan disabilitas (YLDs) paling tinggi dibandingkan OA pada sendi lainnya. Tatalaksana yang diberikan pada tiap individu dengan OA berbeda-beda tergantung kepada faktor risiko, letak lesi, dan tingkat keparahannya. Tingginya prevalensi OA, beban penyakit dan heterogenitas OA sendi lutut menjadi dasar bagi peneliti untuk melakukan penelitian mengenai hubungan antara faktor risiko OA dengan derajat manifestasi klinis OA sendi lutut. Penelitian ini merupakan cross-sectional study observasional analitik menggunakan sampel data primer pasien OA sendi lutut di RSUD Abdoel Wahab Sjahranie Samarinda dan RS Dirgahayu Samarinda. Sebanyak 52 sampel diperoleh melalui total sampling. Data penelitian dianalisis menggunakan uji Pearson Chi-square. Hasil dari penelitian menunjukkan bahwa tidak terdapat hubungan antara usia (p = 0,662), jenis kelamin (p = 0,738), obesitas (p = 0,711), riwayat keluarga (p = 1,000), riwayat trauma (p = 0,254), dan deformitas (p = 1,000) dengan derajat manifestasi klinis OA sendi lutut.


Kata Kunci


Faktor Risiko; Derajat Manifestasi Klinis; Osteoartritis Sendi Lutut

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Referensi


Adawiyah, A. R., Suratmi, T., & Rahardjo, T. B. W. (2020). Kapasitas fungsional dan kualitas hidup lansia wanita dengan osteoartritis lutut. Jurnal untuk Masyarakat Sehat (JUKMAS), 4(1). https://doi.org/10.52643/jukmas.v4i1.787

Anderson, A. S., & Loeser, R. F. (2010). Why is osteoarthritis an age-related disease? Best Practice & Research Clinical Rheumatology, 24(1), 15-26. https://doi.org/10.1016/j.berh.2009.08.006

Bashekah, K. A., Zagzoug, M. E., Banaja, A. W., Alghamdi, A. A., Mishiming, O. S., Jan, M. A., Kemawi, O. A., Alharbi, B. A., Althagafi, A. A., & Aljifri, S. M. (2023). Prevalence and characteristics of knee osteoarthritis among the general public in Saudi Arabia. Cureus, 15(10), e47666. https://doi.org/10.7759/cureus.47666

Blom, A., Warwick, D., & Whitehouse, M. R. (2018). Apley and Solomon’s system of orthopaedics and trauma (10th ed.). Boca Raton: CRC Press.

Felson, D. T. (2013). Osteoarthritis. Dalam A. S. Fauci & C. A. Langford (Eds.), Harrison’s rheumatology (Edisi ke-3). New York: McGraw-Hill Education.

Felson, D. T., Niu J., Gross, K. D., Englund, M., Sharma, L., Cooke, T. D., Guermazi, A., Roemer, F. W., Segal, N., Goggins, J. M., Lewis, C. E., Eaton, C., Nevitt, M. C. (2013). Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: findings from the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative. Arthritis Rheum. 2013 Feb;65(2):355-62.

DOI: 10.1002/art.37726. PMID: 23203672; PMCID: PMC3558618.

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: A systematic analysis for the

Global Burden of Disease Study 2017. The Lancet, 392, 1789-1858. https://doi.org/10.1016/S0140-6736(18)32279-7

GBD 2019 Disease and Injuries Collaborators. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 369(10258), 1204-1222.

https://doi.org/10.1016/S0140-6736(20)30925-9

Hame, S. L., & Alexander, R. A. (2013). Knee osteoarthritis in women. Current Reviews in Musculoskeletal Medicine, 6(2), 182-187. https://doi.org/10.1007/s12178-013-9164-0

Hanif, M. H., Abdullah, A., Garianto, E., & Risma. (2023). Hubungan antara indeks massa tubuh dengan tinggi skor Western Ontario and McMaster University Osteoarthritis Index pada pasien osteoarthritis lutut di RSPAL dr. Ramelan Surabaya. Surabaya Biomedical Journal, 2(3), 140-149. https://doi.org/10.30649/sbj.v2i3.92

Hunter, D. J., & Bierma-Zeinstra, S. (2019). Osteoarthritis. The Lancet, 393(10182), 1745-1759. https://doi.org/10.1016/S0140-6736(19)30417-9

Jandrić, S., & Manojlović, S. (2009). Quality of life of men and women with osteoarthritis of the hip and arthroplasty. American Journal of Physical Medicine & Rehabilitation, 88(4), 328–335.

https://doi.org/10.1097/phm.0b013e318194fa24

Kementerian Kesehatan Republik Indonesia. (2018). Laporan nasional Riskesdas 2018: Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI. https://dinkes.babelprov.go.id/sites/default/files/dokumen/bank_data/20181228%20-%20Laporan%20Riskesdas%202018%20Nasional-1.pdf (Diakses pada 15 September 2023)

Khella, C. M., Asgarian, R., Horvath, J. M., Rolauffs, B., & Hart, M. L. (2021). An evidence-based systematic review of human knee post-traumatic osteoarthritis (PTOA): Timeline of clinical presentation and disease markers, comparison of knee joint PTOA models and early disease implications. International Journal of Molecular Sciences, 22(4), 1996. https://doi.org/10.3390/ijms22041996

Kusuma, D. P., Warlisti, I. V., & Widiastuti, L. P. (2019). Hubungan IMT ≥ 23 terhadap derajat keparahan osteoartritis berdasarkan radiologi Kellgren Lawrence dan indeks WOMAC. Jurnal Kedokteran Diponegoro, 8(3), 947-954. https://doi.org/10.14710/dmj.v8i3.24420

Liu, Y. P., Li, J., Xin, S. B., & X, J. (2018). Study the relevance between inflammatory factors and estradiol and their association with knee osteoarthritis in postmenopausal women. European Review for Medical and Pharmacological Sciences, 22(2), 472-478. https://doi.org/10.26355/eurrev_201801_14197

Loeser, R. F., Collins, J. A., & Diekman, B. O. (2016). Ageing and the pathogenesis of osteoarthritis. Nature Reviews Rheumatology, 12(7), 412-420. https://doi.org/10.1038/nrrheum.2016.65

Long, H., Liu, Q., Yin, H., Wang, K., Diao, N., Zhang, Y., Lin, J., & Guo, A. (2022). Prevalence trends of site-specific osteoarthritis from 1990 to 2019: Findings from the Global Burden of Disease Study 2019. Journal of Arthritis & Rheumatology, 74(7), 1172-1183.

https://doi.org/10.1002/art.42089

Maqbool, M., Fekadu, G., Jiang, X., Bekele, F., Tolossa, T., Turi, E., Fetensa, G., & Fanta, K. (2021). An up-to-date on clinical prospects and management of osteoarthritis (Review). Annals of Medicine and Surgery, 72, 103007. https://doi.org/10.1016/j.amsu.2021.103077

Muthuri, S. G., McWilliams, D. F., Doherty, M., & Zhang, W. (2011). History of knee injuries and knee osteoarthritis: a meta-analysis of observational studies. Osteoarthritis and cartilage, 19(11), 1286–1293. https://doi.org/10.1016/j.joca.2011.07.015

Palazzo, C., Nguyen, C., Lefevre-Colau, M. M., Rannou, F., & Poiraudeau, S. (2016). Risk factors and burden of osteoarthritis. Annals of Physical and Rehabilitation Medicine, 59(3), 134-138. https://doi.org/10.1016/j.rehab.2016.01.006

Perhimpunan Reumatologi Indonesia. (2021). Diagnosis dan Pengelolaan Osteoartritis (Lutut, Tangan, dan Panggul). Jakarta: Perhimpunan Reumatologi Indonesia.

Racher, V., Wirth, W., Zimmermann, G., Bathke, A., & Eckstein, F. (2020). Dependence of WOMAC pain on radiographic knee OA status, age, sex, body mass index (BMI), race, and contralateral knee pain status. Journal of Osteoarthritis and Cartilage, 28(1), 141-142. https://doi.org/10.1016/j.joca.2020.02.233

Raud, B., Gay, C., Guiguet-Auclair, C., Bonnin, A., Gerbaud, L., Pereira, B., Duclos, M., Boirie, Y., & Coudeyre, E. (2020). Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis. Scientific Reports, 10(1), 3601. https://doi.org/10.1038/s41598-020-60587-1

Sananta, P., Firiadi, H. A., Widasmara, D., & Fuzianingsih, E. N. (2022). Age and knee osteoarthritis severity relationship in Indonesian secondary referral hospital. Jurnal Berkala Kesehatan, 8(2), 124-131. https://doi.org/10.20527/jbk.v8i2.14608

Silverwood, V., Blagojevic-Bucknall, M., Jinks, C., Jordan, J. L., Protheroe, J., & Jordan, K. P. (2015). Current evidence on risk factors for knee osteoarthritis in older adults: A systematic review and meta-analysis. Journal of Osteoarthritis and Cartilage, 23, 507-515. https://doi.org/10.1016/j.joca.2014.11.019

Soeroso, J., Isbagio, H., Kalim, H., Broto, R., & Pramudiyo, R. (2014). Osteoartritis. Dalam S. Setiati, I. Alwi, A. W. Sudoyo, M. S. Kolopaking, B. Setiyonadi, & A. F. Syam (Eds.), Buku ajar ilmu penyakit dalam (Jilid III, Edisi IV). Jakarta: Interna Publishing.

Spector, T. D., & MacGregor, A. J. (2004). Risk factors for osteoarthritis: Genetics. Journal of Osteoarthritis and Cartilage, 12(Suppl), 39-44. https://doi.org/10.1016/j.joca.2003.09.005

Teichtahl, A. J., Wang, Y., Wluka, A. E., & Cicuttini, F. M. (2008). Obesity and knee osteoarthritis: New insights provided by body composition studies. Obesity (Silver Spring), 16(2), 232-240. https://doi.org/10.1038/oby.2007.30

Washilah, K., Siddik, M., & Sanyoto, D. D. (2021). Literature review. Jurnal Mahasiswa Pendidikan Dokter, 4(3). https://doi.org/10.20527/ht.v4i3.4557

Wei, J., Gross, D., Lane, N. E., Lu, N., Wang, M., Zeng, C., Yang, T., Lei, G., Choi, H. K., & Zhang, Y. (2018). Risk factor heterogeneity for medial and lateral compartment knee osteoarthritis: Analysis of two prospective cohorts. Journal of Osteoarthritis and Cartilage, 27(2019), 603-610. https://doi.org/10.1016/j.joca.2018.12.013

Weiss, E. (2014). Knee osteoarthritis, body mass index and pain: Data from the Osteoarthritis Initiative. Rheumatology, 53(11), 2095–2099. https://doi.org/10.1093/rheumatology/keu244

World Health Organization. (n.d.). Osteoarthritis. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/osteoarthritis




DOI: https://doi.org/10.33024/jikk.v12i3.18108

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