Karakteristik Pasien Gangguan Ginjal Akut Di ICU RSUD DR. H. Chasan Boesoirie Ternate
Sari
Gangguan ginjal akut (GGA) adalah penurunan fungsi ginjal secara mendadak dalam beberapa jam sampai beberapa hari yang berakibat pada retensi limbah metabolisme dan disregulasi homeostasis cairan, elektrolit, dan asam basa. Insidensi GGA dunia didapatkan 20% pada pasien rumah sakit dan paling banyak ditemukan pada pasien dengan penyakit kritis di ruang intensive care unit (ICU) dengan prevalensi 50% sampai 67%. Penelitian ini dilakukan untuk mengetahui karakteristik pasien GGA di ICU RSUD Dr. H. Chasan Boesoirie (RSCB) Ternate. Penelitian ini merupakan penelitian retrospektif deskriptif observasional dengan pendekatan cross sectional menggunakan status rekam medik pasien dengan teknik total sampling. Dari total 98 sampel pasien GGA di ICU, dimana mayoritas berjenis kelamin laki-laki (56%), berusia lansia (44.4%), sepsis sebagai penyakit dasar (23.5%), penyakit komorbid sepsis (56.1%), homoglobin rendah (74.5%), hiponatremia (36.7%), normokalemia (44.9%), normokloremia (53.1%), uremia (83.7%), hiperkreatinemia (91.8%), output urine normal (41.8%), dan luaran pascarawat meninggal (77.6%). Hasil tersebut menunjukkan bahwa karakteristik frekuensi tertinggi GGA di ICU yakni laki-laki, lansia, sepsis sebagai penyakit dasar, penyakit komorbid terbanyak sepsis, hemoglobin rendah, hiponatremia, normokalemia, normokloremia, uremia, hiperkreatinemia, output urine normal, dan meninggal.
Kata Kunci
Teks Lengkap:
PDFReferensi
Abdel-Kader, K. and Palevsky, P.M. (2009) ‘Acute Kidney Injury in the Elderly’, Clinics in Geriatric Medicine, pp. 331–358. Available at: https://doi.org/10.1016/j.cger.2009.04.001.
Åhlström, A. et al. (2005) ‘Survival and quality of life of patients requiring acute renal replacement therapy’, Intensive Care Medicine, 31(9), pp. 1222–1228. Available at: https://doi.org/10.1007/s00134-005-2681-6.
Arifin, H. and Kurniawan, H. (2016) ‘Sensitivitas dan Spesifisitas Cystatin C dan Kreatinin Serum dalam Mendiagnosis Cedera Ginjal Akut pada Pasien Sepsis yang Dirawat di Ruang Rawat Intensif RSUP
H. Adam Malik Medan’, Jurnal Anestesi Perioperatif, (4), pp. 63–71. Available at: https://doi.org/10.15851/jap.v4n2.819.
Bagshaw, S.M. et al. (2005) ‘Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study.’, Critical Care (London, England), 9(6). Available at: https://doi.org/10.1186/cc3879.
Balci, C., Haftaci, E. and Kunt, A.T. (2018) ‘Use of cerebral oxygen saturation and hemoglobin concentration to predict acute kidney injury after cardiac surgery’, Journal of International Medical Research, 46(3), pp. 1130–1137. Available at: https://doi.org/10.1177/0300060517741064.
Case, J. et al. (2013) ‘Epidemiology of acute kidney injury in the intensive care unit’, Critical Care Research and Practice. Available at: https://doi.org/10.1155/2013/479730.
Chavez-Iniguez, J.S. et al. (2023) ‘Urea Reduction in Acute Kidney Injury and Mortality Risk’, Kidney and Blood Pressure Research, 48(1), pp. 357–366. Available at: https://doi.org/10.1159/000530237.
Chawla, L.S. et al. (2017) ‘Impact of Acute Kidney Injury in Patients Hospitalized With Pneumonia’, Critical Care Medicine, 45(4), pp. 600–606. Available at: https://doi.org/10.1097/CCM.000000000000224.
Chen, D. et al. (2021) ‘Impact of acute kidney injury on in-hospital outcomes in Chinese patients with community acquired pneumonia’, BMC Pulmonary Medicine, 21(1). Available at: https://doi.org/10.1186/s12890-021-01511-9.
Chen, X. et al. (2021) ‘Risk scoring systems including electrolyte disorders for predicting the incidence of acute kidney injury in hospitalized patients’, Clinical Epidemiology, 13, pp. 383–396. Available at: https://doi.org/10.2147/CLEP.S311364.
Chertow, G.M. et al. (2006) ‘Mortality after acute renal failure: Models for prognostic stratification and risk adjustment’, Kidney International, 70(6), pp. 1120–1126. Available at: https://doi.org/10.1038/sj.ki.5001579.
Flannery, A.H. et al. (2021) ‘Sepsis-Associated Acute Kidney Disease and Long-term Kidney Outcomes’, Kidney Medicine, 3(4), pp. 507-514.e1. Available at: https://doi.org/10.1016/j.xkme.2021.02.007.
Gibney, N. et al. (2008) ‘Timing of initiation and discontinuation of renal replacement therapy in AKI: Unanswered key questions’, Clinical Journal of the American Society of Nephrology, 3(3), pp. 876–880. Available at: https://doi.org/10.2215/CJN.04871107.
Goyal, A. et al. (2023) Acute kidney injury. StatPearls Publishing. Available at: https://pubmed.ncbi.nlm.nih.gov/28722925/ (Accessed: 2 May 2024).
Güzel C and Yeşiltaş S (2019) The effect of gender on acute kidney injury developing in the intensive care unit, HIPPOKRATIA. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307507/ (Accessed: 10 July 2024).
Hales, M., Solez, K. and Kjellstrand, C. (1994) ‘The Anemia of Acute Renal Failure: Association with Oliguria and Elevated Blood Urea’, Renal Failure, 16, pp. 125–131. Available at: https://doi.org/https://doi.org/10.3109/08860229409044854.
Hoste, E.A.J. et al. (2006) ‘RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis’, Critical Care, 10(3). Available at: https://doi.org/10.1186/cc4915.
Hoste, E.A. and Kellum, J.A. (2004) ‘Acute renal failure in the critically ill: impact on morbidity and mortality’, Contrin Nephrol [Preprint]. Available at: https://doi.org/10.1159/000078872.
Huether, S.E. (2019) ‘Perubahan-Perubahan pada Ginjal dan Fungsi
Saluran Kemih’, in S.E. Huether (ed.) Buku Ajar Patofisiologi. 6th edn. Elsevier, pp. 264–286.
Jordan, M. et al. (2021) ‘Kidney Recovery in Patients With Acute Kidney Injury Treated in Outpatient Hemodialysis or Rehabilitation Facilities’, Kidney Medicine, 3(6), pp. 916-924.e1. Available at: https://doi.org/10.1016/j.xkme.2021.06.012.
Kandarini, Y. (2020) ‘Gangguan Volume, Osmolaritas, dan Elektrolit Cairan’, in I.G.R. Widiana and Y. Kandarini (eds) Gangguan Ginjal, Elektrolit, dan Keseimbangan Asam-Basa. 1st edn. Denpasar: Penerbit Buku Kedokteran ECG, pp. 79–103.
Lee, Jinwoo et al. (2020) ‘Comorbidities can predict the mortality of acute kidney injury requiring continuous renal replacement therapy: comparison with the Charlson comorbidity index’, Korean Journal of Transplantation, 34(1), pp. S115–S115. Available at: https://doi.org/10.4285/atw2020.po-1060.
Lee, S.W. et al. (2016) ‘The effects of pre-existing hyponatremia and subsequently developing acute kidney injury on in-hospital mortality: A retrospective cohort study’, PLoS ONE, 11(9). Available at: https://doi.org/10.1371/journal.pone.0162990.
Loutradis, C. et al. (2021) ‘Acute kidney injury is more common in men than women after accounting for socioeconomic status, ethnicity, alcohol intake and smoking history’, Biology of Sex Differences, 12(1). Available at: https://doi.org/10.1186/s13293-021-00373-4.
Lubart, E. et al. (2023) ‘The incidence of acute renal failure and high mortality rate in elderly patients hospitalized with community-acquired pneumonia’, Experimental Gerontology, 179. Available at: https://doi.org/10.1016/j.exger.2023.112242.
Lydia, A. and Nugroho, P. (2014) ‘Tes Fungsi Ginjal’, in S. Setiati et al. (eds) Buku Ajar Ilmu Penyakit Dalam. 6th edn. Jakarta: InternaPublishing, pp. 250–254.
Ma, H.Y., Chen, S. and Du, Y. (2021) ‘Estrogen and estrogen receptors in kidney diseases’, Renal Failure. Taylor and Francis Ltd., pp. 619–642. Available at: https://doi.org/10.1080/0886022X.2021.1901739.
Marzuki, M.J., Nursamsu, N. and Rifai, A. (2022) ‘Perbandingan Mortalitas, Lama Rawat, Perbaikan Fungsi Ginjal, dan Kebutuhan Hemodialisis Selama Perawatan pada Pasien Acute Kidney Injury (AKI) dengan dan Tanpa Sepsis, Serta Faktor yang Memengaruhi Mortalitas Pasien’, Jurnal Penyakit Dalam Indonesia, 9(1), p. 4. Available at: https://doi.org/10.7454/jpdi.v9i1.623.
Maskoen, T.T. and Akbar, D. (2023) ‘Injuri ginjal akut akibat sepsis pada pasien di ICU’, JAI (Jurnal Anestesiologi Indonesia), 15(1), pp. 69–85. Available at: https://doi.org/https://doi.org/10.14710/jai.v0i0.49464.
Md Ralib, A. et al. (2013) ‘The urine output definition of acute kidney injury is too liberal’, Critical Care, 17(3). Available at: https://doi.org/10.1186/cc12784.
Neyra, J.A. et al. (2019) ‘A Multidisciplinary Approach for the Management of Severe Hyponatremia in Patients Requiring Continuous Renal Replacement Therapy’, Kidney International Reports, 4(1), pp. 59–66. Available at: https://doi.org/10.1016/j.ekir.2018.09.001.
Ricci, Z., Cruz, D. and Ronco, C. (2008) ‘The RIFLE criteria and mortality in acute kidney injury: A systematic review’, Kidney International. Nature Publishing Group, pp. 538–546. Available at: https://doi.org/10.1038/sj.ki.5002743.
Sabaghian, T. et al. (2022) ‘Effect of Electrolyte Imbalance on Mortality and Late Acute Kidney Injury in Hospitalized COVID-19 Patients’, Iranian Journal of Kidney Diseases, 16(4), pp. 228–237. Available at: https://doi.org/10.52547/ijkd.6904.
Saxena, A. and Meshram, S. V. (2018) ‘Predictors of mortality in acute kidney injury patients admitted to medicine intensive care unit in a Rural Tertiary Care Hospital’, Indian Journal of Critical Care Medicine, 22(4), pp. 231–237. Available at: https://doi.org/10.4103/ijccm.IJCCM_462_17.
Setiawan, D. et al. (2018) Biomarker Acute Kidney Injury (AKI) pada Sepsis, Jurnal Kesehatan Andalas. Available at: http://jurnal.fk.unand.ac.id.
Silver, S.A. et al. (2018) ‘Causes of death after a hospitalization with AKI’, Journal of the American Society of Nephrology, 29(3), pp. 1001–1010. Available at: https://doi.org/10.1681/asn.2017080882.
Sukesi, L. et al. (2023) Konsensus gangguan ginjal akut. 1st edn. Jakarta Pusat: Pernefri. Available at: www.pernefri.org.
Surachno, R.G. (2014) ‘Ilmu penyakit dalam’, in S. Setiati et al. (eds) Bandiara, Ria. 6th edn. Jakarta: InternaPublishing, pp. 2149–2160.
Uchino, S. et al. (2005) ‘Acute renal failure in critically ill patients: a multinational, multicenter study’, Journal of The American Medical Association, 294(7), pp. 813–818. Available at: https://doi.org/10.1001/jama.294.7.813.
Vaara, S.T. et al. (2016) ‘Association of oliguria with the development of acute kidney injury in the critically ill’, Kidney International, 89(1), pp. 200–208. Available at: https://doi.org/10.1038/ki.2015.269.
Woodrow, G. and Turney, J.H. (1992) ‘Cause of death in acute renal failure’, Nephrology Dialysis Transplantation, 7(3), pp. 230–234. Available at: https://doi.org/https://doi.org/10.1093/oxfordjournals.ndt.a092111.
Yamashita, T. et al. (2016) ‘Erythropoietin concentration in acute kidney injury is associated with insulin-like growth factor-binding protein-1’, Nephrology, 21(8), pp. 693–699. Available at: https://doi.org/https://doi.org/10.1111/nep.12656.
Yang, L. (2016) ‘Acute Kidney Injury in Asia’, Kidney Diseases, 2(3), pp. 95–102. Available at: https://doi.org/10.1159/000441887.
Yokota, L.G. et al. (2018) ‘Acute kidney injury in elderly patients: Narrative review on incidence, risk factors, and mortality’, International Journal of Nephrology and Renovascular Disease. Dove Medical Press Ltd, pp. 217–224. Available at: https://doi.org/10.2147/IJNRD.S170203.
Zeng, Z. et al. (2022) ‘Predicting mortality in acute kidney injury patients undergoing continuous renal replacement therapy using a visualization model: A retrospective study’, Frontiers in Physiology, 13. Available at: https://doi.org/10.3389/fphys.2022.964312.
Zhao, J. V. and Schooling, C.M. (2020) ‘The role of testosterone in chronic kidney disease and kidney function in men and women: A bi-directional Mendelian randomization study in the UK Biobank’, BMC Medicine, 18(1). Available at: https://doi.org/10.1186/s12916-020-01594-x.
DOI: https://doi.org/10.33024/jikk.v12i4.18675
Refbacks
- Saat ini tidak ada refbacks.
##submission.copyrightStatement##
##submission.license.cc.by-nc4.footer##
Pendidikan Dokter Universitas Malahayati Lampung

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.