_JIKK_2024-2.pdf_.png)
1.png){kind=logo}
.png)
.png)
.png)
.jpg)
Inventarisasi Tanaman Herbal Berpotensi Sebagai Anti-Kanker, Anti-Mikroba Dan Imunomodulator Di Kota Metro Lampung
Sari
Kanker tetap menjadi penyebab utama kematian dan masih menjadi masalah kesehatan masyarakat yang signifikan di Kota Metro, dengan angka kejadian yang tercatat oleh Dinas Kesehatan relatif tinggi. Faktor yang berkontribusi antara lain penyakit infeksi dan penurunan imunitas, sementara keterbatasan dalam upaya pencegahan serta terapi pada stadium lanjut memperburuk permasalahan ini. Tanaman herbal banyak dimanfaatkan oleh masyarakat dan secara tradisional diyakini mampu mencegah inisiasi kanker, khususnya pada gejala awal seperti munculnya benjolan. Bukti penelitian sebelumnya juga mendukung potensinya sebagai imunomodulator, antimikroba, dan antikanker melalui mekanisme seperti penghambatan virus dan supresi karsinogenesis. Penelitian ini bertujuan untuk mengidentifikasi tanaman herbal yang umum digunakan oleh masyarakat Kota Metro untuk pencegahan kanker dan peningkatan imunitas. Desain penelitian yang digunakan adalah deskriptif kualitatif yang dilaksanakan di lima kecamatan (Metro Pusat, Metro Timur, Metro Selatan, Metro Barat, dan Metro Utara) pada Februari hingga Juni 2025, dengan pengumpulan data melalui wawancara, survei terhadap 25 responden, dan telaah literatur. Hasil penelitian menunjukkan bahwa masyarakat secara luas memanfaatkan berbagai jenis tanaman herbal dengan aktivitas antimikroba, antikanker, dan imunomodulator, di antaranya Zingiber officinale, Curcuma zedoaria, Curcuma longa, Curcuma zanthorrhiza, Andrographis paniculata, Typhonium flagelliforme, Alpinia galanga, Allium sativum, Cymbopogon citratus, Annona muricata, Piper betle, Zingiber zerumbet, Cuminum cyminum, Citrus aurantifolia, Kaempferia galanga, Clitoria ternatea, Moringa oleifera, Phyllanthus urinaria, Curcuma aeruginosa, Camellia sinensis, dan Curcuma heyneana.
Kata Kunci
Teks Lengkap:
PDFReferensi
Ahlina, F. N., Nugraheni, N., Salsabila, I. A., Haryanti, S., Da'i, M., & Meiyanto, E. (2020). Revealing the Reversal Effect of Galangal (Alpinia galanga L.) Extract Against Oxidative Stress in Metastatic Breast Cancer Cells and Normal Fibroblast Cells Intended as a Co- Chemotherapeutic and Anti-Ageing Agent. Asian Pacific journal of cancer prevention : APJCP, 21(1), 107–117. https://doi.org/10.31557/APJCP.2020.21.1.107.
Busia, K. (2024). Herbal Medicine Dosage Standardisation. Journal of Herbal Medicine. 46. 100889. 10.1016/j.hermed.2024.100889.
Cahyani, F., Farizaldi, R. I., Syafaati, L. M., Hartanli, A. L., &
Aryandhita, A. P. P. . (2023). Anti-microbial efficacy of garlic (Allium Sativum L.) extract as a root canal irrigant in endodontic treatment. Conservative Dentistry Journal, 13(2), 91–95. https://doi.org/10.20473/cdj.v13i2.2023.91-95.
Centers for Disease Control and Prevention. (2023). Smoking and Tobacco Use: What is Cancer.https://www.cdc.gov/tobacco/basic_information/health_effects/cancer/ind ex.htm.Diakses pada 13 Januari 2025.
Chandrasekaran, R., Krishnan, M., Chacko, S., Gawade, O., Hasan, S., Joseph, J., George, E., Ali, N., AlAsmari, A. F., Patil, S., & Jiang, H. (2023). Assessment of anticancer properties of cumin seed (Cuminum cyminum) against bone cancer. Frontiers in oncology, 13, 1322875. https://doi.org/10.3389/fonc.2023.1322875
Chang, J. S., Wang, K. C., Yeh, C. F., Shieh, D. E., & Chiang, L. C. (2013). Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Journal of ethnopharmacology, 145(1), 146–151. https://doi.org/10.1016/j.jep.2012.10.043
Chauhan, P. S., Satti, N. K., Suri, K. A., Amina, M., & Bani, S. (2010). Stimulatory effects of Cuminum cyminum and flavonoid glycoside on Cyclosporine-A and restraint stress induced immune-suppression in Swiss albino mice. Chemico-biological interactions, 185(1), 66–72. https://doi.org/10.1016/j.cbi.2010.02.016
Chouni, A., & Paul, S. (2018). A review on phytochemical and pharmacological potential of Alpinia galanga. Pharmacognosy Journal, 10(1).
Depi Damayanti. (2022). Literatur Review and Docking Several Antivirals.https://repository.unhas.ac.id/id/eprint/17863/2/N011181034_skripsi_20-07-
Dinkes Kota Metro. (2023). Profil Kesehatan Kota Metro. https://dinkes.metrokota.go.id/wp-content/uploads/sites/84/2024/08/PROFIL- KESEHATAN-KOTA-METRO-2023-TTD-LAMPIRAN.pdf. Diakses pada 12 Januari 2025.
Eva Johannes.,Andi Ilham, L.,Mustika Tuwo., Sry Sukmawaty. (2021). Efektivitas Ekstrak Daun Eceng Gondok (Eichornia crassipes) Sebagai Bahan Anti Kanker pada sel Tumor MCF-7 dengan Metode In Vivo dan In Silico. Jurnal Ilmu Alam dan Lingkungan. 12(1). 39-44.
Fajrin, F. A., Sulistyowaty, M. I., Ghiffary, M. L., Zuhra, S. A., Panggalih, W. R., Pratoko, D. K., Christianty, F. M., Matsunami, K., &
Indrianingsih, A. W. (2023). Immunomodulatory effect from ethanol extract and ethyl acetate fraction of Curcuma heyneana Valeton and Zijp: Transient receptor vanilloid protein approach. Heliyon, 9(5), e15582. https://doi.org/10.1016/j.heliyon.2023.e15582
Girisa, S., Shabnam, B., Monisha, J., Fan, L., Halim, C. E., Arfuso, F., Ahn, K. S., Sethi, G., & Kunnumakkara, A. B. (2019). Potential of Zerumbone as an Anti-Cancer Agent. Molecules (Basel, Switzerland), 24(4), 734. https://doi.org/10.3390/molecules24040734
Halimah,. Nor syipa., Nurul Huda.,et al. (2024). Prediksi Senyawa Tanaman Pegagan dengan Aktivitas Kanker Darah Secara Molekuler Docking. Jurnal Farmasi Islam Kalimantan. 1(2).
Ilango, S., Sahoo, D. K., Paital, B., Kathirvel, K., Gabriel, J. I., Subramaniam, K., Jayachandran, P., Dash, R. K., Hati, A. K., Behera, T. R., Mishra, P., & Nirmaladevi, R. (2022). A Review on Annona muricata and Its Anticancer Activity. Cancers, 14(18), 4539. https://doi.org/10.3390/cancers14184539.
Islam, M. A., Mondal, S. K., Islam, S., Akther Shorna, M. N., Biswas, S., Uddin, M. S., Zaman, S., & Saleh, M. A. (2023). Antioxidant, Cytotoxicity, Antimicrobial Activity, and In Silico Analysis of the Methanolic Leaf and Flower Extracts of Clitoria ternatea. Biochemistry research international, 2023, 8847876. https://doi.org/10.1155/2023/8847876.
Kemenkes. (2022). Kanker Payudara paling Banyak di Indonesia, Kemenkes Targetkan Pemerataan Pelayanan. https://sehatnegeriku.kemkes.go.id/baca/umum/20220202/1639254/kanker- payudaya-paling-banyak-di-indonesia-kemenkes-targetkan-pemerataan-layanan- kesehatan/. Diakses pada 13 Januari 2025.
Kim H, Lee DW, Hwang JK. Curcuma xanthorrhiza extract and xanthorrhizol ameliorate cancer-induced adipose wasting in CT26-bearing mice by regulating lipid metabolism and adipose tissue browning. Integr Med Res. 2024 Mar;13(1):101020. doi: 10.1016/j.imr.2023.101020. Epub 2023 Dec 24. PMID: 38298864; PMCID: PMC10826318.
Kusumawati, I., Kurniawan, K. O., Rullyansyah, S., Prijo, T. A., Widyowati, R., Ekowati, J., Hestianah, E. P., Maat, S., & Matsunami, K. (2018). Anti-aging properties of Curcuma heyneana Valeton & Zipj: A scientific approach to its use in Javanese tradition. Journal of ethnopharmacology, 225, 64–70.
https://doi.org/10.1016/j.jep.2018.06.038
Lisa Andriani, L., Kharirie. (2020). Daun Sirsak (Annona Muricata) dan Potensinya Sebagai Anti Kanker. Pros Sem Nas Masy Biodiv Indon. 6(1). 653-657.
Moreira da Silva, T., Pinheiro, C. D., Puccinelli Orlandi, P., Pinheiro, C. C., & Soares Pontes, G. (2018). Zerumbone from Zingiber zerumbet (L.) smith: a potential prophylactic and therapeutic agent against the cariogenic bacterium Streptococcus mutans. BMC complementary and alternative medicine, 18(1), 301. https://doi.org/10.1186/s12906-018-2360-0
Naomi R, Bahari H, Ong ZY, Keong YY, Embong H, Rajandram R, Teoh SH, Othman F, Hasham R, Yin KB, Kaniappan P, Yazid MD, Zakaria ZA. Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling
Pathway. Int J Mol Sci. (2022). 23(11):5972. doi: 10.3390/ijms23115972. PMID: 35682652; PMCID: PMC9181071.
Nugraha, A. S., Damayanti, Y. D., Wangchuk, P., & Keller, P. A. (2019). Anti-infective and anti-cancer properties of the Annona species: Their ethnomedicinal uses, alkaloid diversity, and pharmacological activities. Molecules, 24(23), 4419.
Panyajai, P., Viriyaadhammaa, N., Tima, S., Chiampanichayakul, S., Dejkriengkraikul, P., Okonogi, S., & Anuchapreeda, S. (2024). Anticancer activity of Curcuma aeroginosa essential oil and its nano-formulations: cytotoxicity, apoptosis and cell migration effects. BMC complementary medicine and therapies, 24(1), 16. https://doi.org/10.1186/s12906-023-04261-9
Pareek, A., Pant, M., Gupta, M. M., Kashania, P., Ratan, Y., Jain, V., Pareek, A., & Chuturgoon, A. A. (2023). Moringa oleifera: An Updated Comprehensive Review of Its Pharmacological Activities, Ethnomedicinal, Phytopharmaceutical Formulation, Clinical, Phytochemical, and Toxicological Aspects. International journal of molecular sciences, 24(3), 2098. https://doi.org/10.3390/ijms24032098
Parvez MK, Al-Dosari MS, Arbab AH, Niyazi S. (2019). The in vitro and in vivo anti-hepatotoxic, anti-hepatitis B virus and hepatic CYP450 modulating potential of Cyperus rotundus. Saudi Pharm Journal. 27(4):558– 64.https://doi.org/10.1016/j.jsps.2019.02.003
Pina miduk, RM.,Imam Adi, W. (2020). Aktivitas Anti Virus Hepatitis B pada Beberapa Tanaman dengan Metode Pengujian In Vivo dan In Vitro: Review Jurnal. Farmaka. 18(2). 173-190.
Priosoeryanto BP, Rostantinata R, Harlina E, Nurcholis W, Ridho R, Sutardi LN. In vitro antiproliferation activity of Typhonium flagelliforme leaves ethanol extract and its combination with canine interferons on several tumor-derived cell lines. Vet World. 2020 May;13(5):931-939. doi: 10.14202/vetworld.2020.931-939. Epub
May 19. PMID: 32636590; PMCID: PMC7311872.
Rizki Muhammad, Z.,Riezki, A. (2018). Artikel Tinjauan: Anti Kanker dari Tanaman Herbal. Farmaka. 16(1).
Saahene, R. O., Agbo, E., Barnes, P., Yahaya, E. S., Amoani, B., Nuvor, S. V., & Okyere, P. (2021). A Review: Mechanism of Phyllanthus urinaria in Cancers-NF-κB, P13K/AKT, and MAPKs Signaling Activation. Evidence-based complementary and alternative medicine : eCAM, 2021, 4514342. https://doi.org/10.1155/2021/4514342
Salehi, B., Zakaria, Z. A., Gyawali, R., Ibrahim, S. A., Rajkovic, J., Shinwari, Z. K., ... & Setzer, W. N. (2019). Piper species: A comprehensive review on their phytochemistry, biological activities and applications. Molecules, 24(7), 1364.
Salsabila Ariefani.,Eko Fuji Ariyanto.,Yohana Azhar. (2023). Telaah Pustaka: Tanaman Herbal yang Berpotensi Memiliki Efek Anti Kanker Payudara. Jurnal Kedokteran dan Kesehatan: Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya. 10(1). DOI:10.32539/JKK.VI011.19807
Sarmawaty Kotala.,Tri Santi, K. (2022). Eksplorasi Tumbuhan Obat Berpotensi Imunomodulator di Kecamatan Leihitu Kabupaten Maluku Tengah. Sainmatika: Jurnal Ilmiah Matematika dan Ilmu Pengetahuan Alam. 19(2). 186-200.
Sasaki, Y., Norikura, T., Matsui-Yuasa, I., Fujii, R., Limantara, L., & Kojima-Yuasa, A. (2023). Kaempferia galanga L. extract and its main component, ethyl p-methoxycinnamate, inhibit the proliferation of Ehrlich ascites tumor cells by suppressing TFAM expression. Heliyon, 9(6), e17588. https://doi.org/10.1016/j.heliyon.2023.e17588
Schiller, J. T., & Lowy, D. R. (2021). An Introduction to Virus Infections and Human Cancer. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le
cancer, 217, 1–11. https://doi.org/10.1007/978- 3-030-57362-1_1.
Sen, Z., Zhan, X. K., Jing, J., Yi, Z., & Wanqi, Z. (2013).
Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells. Oncology letters, 5(2), 641–644. https://doi.org/10.3892/ol.2012.1042.
Subramaniam G, Yew XY, Sivasamugham LA. (2020). Antibacterial activity of Cymbopogon citratus against clinically important bacteria. S Afr J Chem Eng 34: 26-30. DOI: 10.1016/j.sajce.2020.05.010.
Tajbakhsh M, Soleimani N. (2018). Evaluation of the bactericidal effects of Zingiber officinale, Aloysia citrodora and Artemisia dracunculus on the survival of standard gram-positive and gram-negative bacterial strains. Jorjani Biomed J.6(1):22–32.
doi:10.29252/jorjanibiomedj.6.1.22.
Maksimović, T., Minda, D., Șoica, C., Mioc, A., Mioc, M., Colibășanu, D., Lukinich-Gruia, A. T., Pricop, M. A., Jianu, C., & Gogulescu, A. (2025). Anticancer Potential of Cymbopogon citratus L. Essential Oil: In Vitro and In Silico Insights into Mitochondrial Dysfunction and Cytotoxicity in Cancer Cells. Plants (Basel, Switzerland), 14(9), 1341. https://doi.org/10.3390/plants14091341
Tomeh MA, Hadianamrei R, Zhao X. A Review of Curcumin and Its Derivatives as Anticancer Agents. Int J Mol Sci. 2019 Feb 27;20(5):1033. doi: 10.3390/ijms20051033. PMID: 30818786; PMCID: PMC6429287.
Wang, S. Y., Zhao, H., Xu, H. T., Han, X. D., Wu, Y. S., Xu, F. F., ... & Liu, B. (2021). Kaempferia galanga L.: progresses in phytochemistry, pharmacology, toxicology and ethnomedicinal uses. Frontiers in Pharmacology, 12, 675350.
Xiao, X., Wang, J., Meng, C., Liang, W., Wang, T., Zhou, B., Wang, Y., Luo, X., Gao, L., & Zhang, L. (2020). Moringa oleifera Lam and its Therapeutic Effects in Immune Disorders. Frontiers in pharmacology, 11, 566783. https://doi.org/10.3389/fphar.2020.566783
Zhang, S., Xiao, X., Yi, Y. et al. (2024). Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets. Sig Transduct Target Ther. 149. https://doi.org/10.1038/s41392-024-01848-.
DOI: https://doi.org/10.33024/jikk.v12i9.22047
Refbacks
- Saat ini tidak ada refbacks.
##submission.copyrightStatement##
##submission.license.cc.by-nc4.footer##
Pendidikan Dokter Universitas Malahayati Lampung
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.