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PERANAN KURVA DISOSIASI KARBON DIOKSIDA PADA PROSES PERNAFASAN : KAJIAN PUSTAKA
Sari
Karbon dioksida (CO₂) merupakan produk akhir metabolisme aerobik yang memiliki peran vital dalam fisiologi pernapasan dan keseimbangan asam-basa tubuh. Artikel tinjauan ini membahas mekanisme pertukaran CO₂ mulai dari difusi alveolar, transportasi dalam darah (terlarut, sebagai bikarbonat, dan terikat hemoglobin), hingga kurva disosiasi CO₂. Efek Bohr dan Haldane dijelaskan sebagai mekanisme adaptif yang mendukung efisiensi pengangkutan gas respirasi. Selain proses fisiologis normal, artikel ini juga mengulas kondisi patologis yang mengganggu pertukaran CO₂, seperti hipoventilasi, gangguan ventilasi-perfusi, dan difusi terbatas. Pemahaman yang mendalam mengenai dinamika CO₂ memiliki implikasi klinis penting, khususnya dalam penatalaksanaan penyakit seperti PPOK, asma, dan ARDS. Dengan pendekatan ilmiah yang humanis, artikel ini bertujuan memperkuat pemahaman tenaga medis dan pembaca umum terhadap peran esensial CO₂ dalam menjaga homeostasis dan kehidupan.
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Arthurs, G.J., Sudhakar, M., 2005. Carbon dioxide transport. Contin. Educ. Anaesthesia, Crit. Care Pain 5, 207–210.
Belkin, R.A., Henig, N.R., Singer, L.G., Chaparro, C., Rubenstein, R.C., Xie, S.X., Yee, J.Y., Kotloff, R.M., Lipson, D.A., Bunin, G.R., 2006. Risk factors for death of patients with cystic fibrosis awaiting lung transplantation. Am. J. Respir. Crit. Care Med. 173, 659–666.
Berbenetz, N., Wang, Y., Brown, J., Godfrey, C., Ahmad, M., Vital, F.M., Lambiase, P., Banerjee, A., Bakhai, A., Chong, M., 2019. Non‐invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. Cochrane Database Syst. Rev. 2019.
Bohr effect- Oxygen dissociation curve and effects of CO2 - Online Biology Notes [WWW Document], 2017. URL https://www.onlinebiologynotes.com/bohr-effect-oxygen-dissociation-curve-and-effects-of-co2/ (accessed 6.26.22).
Boron, W.F., 2009. Transport of Oxygen and Carbon Dioxide in the Blood. Med. Physiol. 672–684.
Christiansen, J., Douglas, C.G., Haldane, J.S., 1914. The absorption and dissociation of carbon dioxide by human blood. J. Physiol. 48, 244–271.
Cummins, E.P., Selfridge, A.C., Sporn, P.H., Sznajder, J.I., Taylor, C.T., 2014. Carbon dioxide-sensing in organisms and its implications for human disease. Cell. Mol. Life Sci. 71, 831.
Defares, J.G., Visser, B.F., 1962. On the Form of the Physiological CO2 Dissociation Curve, the Physiological O2 Dissociation Curve, and the Diffusion Curves of O2 and CO2 Along the Capillary Path. Ann. N. Y. Acad. Sci. 96, 939–955.
Ganong, W.F., 2003. Review Of Medical Physiology - 21st Ed. (2003). The McGraw-Hill Companies.
Geers, C., Gros, G., 2000. Carbon dioxide transport and carbonic anhydrase in blood and muscle. Physiol. Rev. 80, 681–715.
Guyton JE, H.A., 2001. Physical Principles of Gas Exchange; Diffusion of Oxygen and Carbon Dioxide Through the Respiratory Membrane - Respiration - Guyton and Hall Textbook of Medical Physiology, 12th Ed. In: W.B Saunder. pp. 597–682.
Guyton JE, H.A., 2011. Guyton and Hall: Textbook of Medical Physiology, Saunders/Elsevier.
human respiratory system - Abnormal gas exchange | Britannica [WWW Document], n.d. URL https://www.britannica.com/science/human-respiratory-system/Abnormal-gas-exchange (accessed 6.20.22).
Jensen, F.B., 2004. Red blood cell pH, the Bohr effect, and other oxygenation-linked phenomena in blood O2 and CO2 transport. Acta Physiol. Scand. 182, 215–227.
Jhon B West, A.M.L., 2016. Respiratory Physiology: The Essentials 10th Edition, Physical Therapy.
KIRILLOV, V.F., 2003. Carbon dioxide dissociation curve | Article about carbon dioxide dissociation curve by The Free Dictionary [WWW Document]. McGraw-Hill Dict. Sci. Tech. Terms, 6E. URL https://encyclopedia2.thefreedictionary.com/carbon+dioxide+dissociation+curve (accessed 6.22.22).
Klocke, R.A., 1973. Mechanism and kinetics of the Haldane effect in human erythrocytes. J. Appl. Physiol. 35, 673–681.
Klocke, R.A., 1987. Carbon Dioxide Transport. Compr. Physiol. 173–197.
Klocke, R.A., 2022. Human respiratory system - Transport of oxygen | Britannica [WWW Document]. Britannica. URL https://www.britannica.com/science/human-respiratory-system/Transport-of-carbon-dioxide (accessed 6.19.22).
Laserna, E., Sibila, O., Aguilar, P.R., Mortensen, E.M., Anzueto, A., Blanquer, J.M., Sanz, F., Rello, J., Marcos, P.J., Velez, M.I., Aziz, N., Restrepo, M.I., 2012. Hypocapnia and hypercapnia are predictors for ICU admission and mortality in hospitalized patients with community-acquired pneumonia. Chest 142, 1193–1199.
Lindsey, J.S., 2019. Carbon dioxide. In: Access Science. McGraw-Hill Education.
Lumb, A., 2010. Nunn’s Applied Respiratory physiology 7th Edition. Churchill Livingstone/Elsevier.
Malte, H., Lykkeboe, G., 2018. The Bohr/Haldane effect: a model-based uncovering of the full extent of its impact on O2 delivery to and CO2 removal from tissues. https://doi.org/10.1152/japplphysiol.00140.2018 125, 916–922.
Meade, F., n.d. BRITISH JOURNAL OF ANAESTHESIA A FORMULA FOR THE CARBON DIOXIDE DISSOCIATION CURVE. Br. J. Anaesth. 44, 630.
O’Neill, D.P., Robbins, P.A., 2017. A mechanistic physicochemical model of carbon dioxide transport in blood. J. Appl. Physiol. 122, 283–295.
Patel, S., Mohiuddin, S.S., 2020. Physiology, Oxygen Transport And Carbon Dioxide Dissociation Curve. StatPearls 1–4.
Riggs, A.F., 2003. The Bohr Effect. http://dx.doi.org/10.1146/annurev.ph.50.030188.001145 50, 181–204.
Shigemura, M., Lecuona, E., Sznajder, J.I., 2017. Effects of hypercapnia on the lung. J. Physiol. 595, 2431–2437.
Shigemura, M., Sznajder, J.I., 2021. Elevated CO 2 modulates airway contractility. Interface Focus 11.
Shigemura, M., Welch, L.C., Sznajder, J.I., 2020. Hypercapnia Regulates Gene Expression and Tissue Function. Front. Physiol. 11.
Sin, D.D., Man, S.F.P., Marrie, T.J., 2005. Arterial carbon dioxide tension on admission as a marker of in-hospital mortality in community-acquired pneumonia. Am. J. Med. 118, 145–150.
Teboul, J.L., Scheeren, T., 2017. Understanding the Haldane effect. Intensive Care Med. 43, 91–93.
Tyuma, I., 1984. The Bohr Effect and the Haldane Effect in Human Hemoglobin. Jpn. J. Physiol. 34, 205–216.
Vries, H. de, Jonkman, A., Shi, Z.-H., Man, A.S., Heunks, L., 2018. Assessing breathing effort in mechanical ventilation: physiology and clinical implications. Ann. Transl. Med. 6, 387–387.
DOI: https://doi.org/10.33024/jikk.v12i8.22216
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