Dea Okta Pabiola, Khairun Nisa Berawi, Giska Tri Putri


Abstract: Therapeutic Potential of Nutraceuticals in The Prevention of Viral Disease. Viral infectious diseases are a major cause of morbidity worldwide with the potential to increase their spread, turning them into pandemics. Nutrition can play a major role in supporting the immune system and its optimal function. A healthy diet contained in nutraceuticals can play an important role in boosting the immune system and fighting various viral invasions. The aim of this journal is to provide comprehensive information on dietary-based scientific recommendations, evidence, and case studies around the world regarding viral infections, particularly in the current pandemic. The method used is a literature review. After reviewing the immune potential of nutraceuticals based on laboratory studies and human studies, it was concluded that bioactive compounds such as resveratrol, quercetin, curcumin, epigallocatechin gallate (EGCG), N-acetyl cysteine (NAC), and palmitoylethanolamide (PEA) with proven antiviral properties enhance the immune system. immune system thus plays an important role in treating various infections caused by viruses in addition to strengthening the immune system.

Keywords: nutraceutical, immune system, viral infection

Teks Lengkap:



Abba, Y., Hassim, H., Hamzah, H., Noordin, MM. (2015). Antiviral activity of resveratrol against human and animal viruses. Adv Virol. 184241:1–7. doi: 10.1155/2015/184241

Campagna, M & Rivas, C. (2011). Antiviral activity of resveratrol. Biochem Soc Trans. 38:50–3. doi: 10.1042/BST0380050

Choi, H.J., Kim, J.H., Lee, C.H., Ahn, Y.J., Song, J.H., Baek, S.H., et al. (2009). Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus. Antiviral Res. 81:77–81. doi: 10.1016/j.antiviral.2008.10.002

Devaux, C. A., Rolain, J. M., & Raoult, D. (2020). ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 53(3), 425–435. https://doi.org/10.1016/j.jmii.2020.04.015

Hesselink, J.M.K. (2013). Evolution in pharmacologic thinking around the natural analgesic palmitoylethanolamide: from nonspecific resistanceto PPAR- a agonist and effective nutraceutical. J Pain Res. 6:625–34. doi: 10.2147/JPR.S48653

Hesselink, J.M.K., Boer, T., Witkamp, R.F. (2013). Palmitoylethanolamide :a natural body-own anti-inflammatory agent, effective and safe against influenza and common cold. Intl J Inflammation. 2013:151028 doi: 10.1155/2013/151028

IFM. (2019). The Functional Medicine Approach to COVID-19: Virus-Specific Nutraceutical and Botanical Agents. Diakses pada 22 April 2022 dari https://www.ifm.org/newsinsights/the-functional-medicine-approach-to-covid-19-virus-specificnutraceutical-and-botanical-agents

Jayawardena, R., Sooriyaarachchi, P., Chourdakis, M., Jeewandara, C., & Ranasinghe, P. (2020). Enhancing immunity in viral infections, with special emphasis on COVID-19: A review. Diabetes & metabolic syndrome, 14(4), 367–382. https://doi.org/10.1016/j.dsx.2020.04.015

Jennings MR, Parks RJ. (2020). Curcumin as an antiviral agent. Viruses. 12:1242. doi: 10.3390/v12111242

Lin, M.H., Moses, D.C., Hsieh, C.H., Cheng, S.C., Chen, Y.H., Sun, C.Y., et al. (2018). Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes. Antiviral Res. 150:155–63. doi: 10.1016/j.antiviral.2017.12.015

McCarty, M. F., & DiNicolantonio, J. J. (2020). Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus. Progress in cardiovascular diseases, 63(3), 383–385. https://doi.org/10.1016/j.pcad.2020.02.007

Moghadamtousi SZ, Kadir HA, Hassandarvish P, Tajik H, Abubakar S, Keivan K. (2014). A review on antibacterial, antiviral, and antifungal activity of curcumin. Biomed Res Intl. 2014:186864. doi: 10.1155/2014/186864

Ramezankhani R, Solhi R, Memarnejadian A, Nami F, Hashemian SMR, Tricot T, et al. (2020). Therapeutic modalities and novel approaches in regenerative medicine for COVID-19. Int J Antimicrob Agents. (2020) 56:0924–8579. doi: 10.1016/j.ijantimicag.2020.106208

Singh, S., Kola, P., Kaur, D., Singla, G., Mishra, V., Panesar, P. S., Mallikarjunan, K., & Krishania, M. (2021). Therapeutic Potential of Nutraceuticals and Dietary Supplements in the Prevention of Viral Diseases: A Review. Frontiers in nutrition, 8, 679312. https://doi.org/10.3389/fnut.2021.679312

Zahedipour F, Hosseini SA, Sathyapalan T, Majeed M, JamialahmadiT, Al-Rasadi, et al. (2020). Potential effects of curcumin in the treatment of COVID-19 infection. Phytother Res. 34:2911–20. doi: 10.1002/ptr.6738

Zhong Y, Ma C, Shahidi F. (2011). Antioxidant and antiviral activities of lipophilic epigallocatechin gallate (EGCG) derivatives. J Funct Foods. 4:87–93. doi: 10.1016/j.jff.2011.08.003

DOI: https://doi.org/10.33024/jikk.v9i2.6870


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