PREDIKTOR LAMA RAWATAN PASIEN COVID-19 MELALUI PARAMETER BIOMARKER DI RUMAH SAKIT UMUM HAJI MEDAN TAHUN 2020-2021

M Agung Kurnia, Donal Nababan, Vierto Irennius Girsang, Mindo Tua Siagan, Frida Tarigan

Sari


Tujuan Penelitian ini adalah untuk mengetahui prediktor lama rawatan pasien COVID-19 melalui parameter biomarker di Rumah Sakit Umum Haji Medan tahun 2020-2021. Penelitian ini merupakan penelitian analitik dengan desain kohort restrospektif. Data didapat dengan menggunakan rekam medis pasien terdiagnosis COVID-19 yang dirawat di Rumah Sakit Umum Haji Medan. Instrumen penelitian adalah Rekam medis pasien COVID-19 di Rumah Sakit Umum Haji Medan. Populasi dalam penelitian adalah semua rekam medis pasien terkonfirmasi COVID-19 yang dirawat di Rumah Sakit Umum Haji Medan selama periode waktu tahun 2020 sampai 2021, penelitian menggunakan metode total sampel dan terdapat 711 sampel.  Hasil penelitian dari 711 pasien COVID 19 yang menjalani rawat Inap selama tahun 2020 – 2021 di Rumah Sakit Umum Haji Medan provinsi Sumatera Utara didapatkan 144 (20.3%) pasien menjalani lama rawat inap yaitu 7 hari. Dari hasil analisis Univariat di dapatkan rata-rata kadar biomarker pasien yang di rawat inap di Rumah Sakit Umum haji Medan yaitu Hemoglobin 12.7 (g/dL), Eritrosit 4.67 (juta/uL), Trombosit 266 (ribu/mm3), Leukosit 9.8 (ribu/mm3), Limfosit 44 (%), Basofil 0.8 (%), Neutrofil 39 (%), D Dimer 1449 (ug/mL), dan Gula Darah 130.65 (mg/dL). Dari hasil Analisis Bivariat dapatkan bahwa terdapat hubungan antara leukosit dengan nilai (p = 0,002) dan neutrophil dengan nilai (p = 0.013) dimana nilai ini lebih kecil dari (<0,05) yang menunjukkan ada hubungan antara kedua variable dengan lama rawatan pasien COVID 19. Dari hasil analisis Multivariat di dapatkan Biomarker seperti Hemoglobin, Eritrosit, Trombosit, Leukosit, Limfosit, Basofil, Neutrofil, Prokalsitonin, D Diimer dan gula darah memiliki nilai signifikansi (>0.05). Kesimpulan tidak terdapat pengaruh biomarker dengan lama rawatan pasien COVID 19 di rumah sakit Umum Haji Medan.

 


Kata Kunci


COVID 19, Biomarker, Lama Rawatan

Teks Lengkap:

PDF

Referensi


A Fahmia & R Yuni. (2022). Lama Rawat Inap Pasien Terkonfirmasi COVID-19 di Rumah Sakit. Epidemiologi Kesehatan Indonesia, 6(1), 1–12.

Baihaqi, F. A., & Rumaropen, H. (2022). Faktor-Faktor yang Berhubungan dengan Lama Rawat Inap Pasien COVID-19 di RSUD Serui Provinsi Papua: Studi Potong Lintang. Jurnal Penyakit Dalam Indonesia, 8(4), 187. https://doi.org/10.7454/jpdi.v8i4.627

ÇETİN, Ş., ULGEN, A., ŞIVGIN, H., & Lİ, W. (2021). A Study on Factors Impacting Length of Hospital Stay of COVID-19 Inpatients. Journal of Contemporary Medicine, 11(3), 396–404. https://doi.org/10.16899/jcm.911185

Chen, F. J., Li, F. R., Zheng, J. Z., Zhou, R., Liu, H. M., Wu, K. Y., Zhang, B., Dong, H., Lu, J. Y., Lei, C. L., & Wu, X. B. (2021). Factors associated with duration of hospital stay and complications in patients with covid-19. Journal of Public Health and Emergency, 5(December 2020). https://doi.org/10.21037/jphe-20-74

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., Yu, T., Zhang, X., & Zhang, L. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet, 395(10223), 507–513. https://doi.org/10.1016/S0140-6736(20)30211-7

El Halabi, M., Feghali, J., Bahk, J., de Lara, P. T., Narasimhan, B., Ho, K., Sehmbhi, M., Saabiye, J., Huang, J., Osorio, G., Mathew, J., Wisnivesky, J., & Steiger, D. (2022). A novel evidence-based predictor tool for hospitalization and length of stay: insights from COVID-19 patients in New York city. Internal and Emergency Medicine, 0123456789. https://doi.org/10.1007/s11739-022-03014-9

Gormez, S., Ekicibasi, E., Degirmencioglu, A., Paudel, A., Erdim, R., Gumusel, H. K., Eroglu, E., Tanboga, I. H., Dagdelen, S., Sariguzel, N., Kirisoglu, C. E., & Pamukcu, B. (2021). Association between renin–angiotensin–aldosterone system inhibitor treatment, neutrophil–lymphocyte ratio, D-Dimer and clinical severity of COVID-19 in hospitalized patients: a multicenter, observational study. Journal of Human Hypertension, 35(7), 588–597. https://doi.org/10.1038/s41371-020-00405-3

Ilham Arief, Ros Sumarny, Yati, Sumiyati, Indra Kusuma, et al. (2021). Hubungan Karakteristik Klinik Dan Profil Pengobatan Dengan Parameter Hematologi Dan Lama Rawat Pasien Covid-19 Di Rumah Sakit YARSI Jakarta. Journal Ilmiah Indonesia, 6(11), 1–14.

Jiang, F., Deng, L., Zhang, L., Cai, Y., Cheung, C. W., & Xia, Z. (2020). Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19). Journal of General Internal Medicine, 35(5), 1545–1549. https://doi.org/10.1007/s11606-020-05762-w

KEMENKES. (2021). IKHTISAR MINGGUAN COVID-19. September, 1–21.

King, A. H., Mehkri, O., Rajendram, P., Wang, X., Vachharajani, V., & Duggal, A. (2021). A High Neutrophil-Lymphocyte Ratio Is Associated With Increased Morbidity and Mortality in Patients With Coronavirus Disease 2019. Critical Care Explorations, 3(5), e0444. https://doi.org/10.1097/cce.0000000000000444

Li, X., Geng, M., Peng, Y., Meng, L., & Lu, S. (2020). Molecular immune pathogenesis and diagnosis of COVID-19. Journal of Pharmaceutical Analysis, 10(2), 102–108. https://doi.org/10.1016/j.jpha.2020.03.001

Li, Y., Zhao, K., Wei, H., Chen, W., Wang, W., Jia, L., Liu, Q., Zhang, J., Shan, T., Peng, Z., Liu, Y., & Yan, X. (2020). Dynamic relationship between D-dimer and COVID-19 severity. British Journal of Haematology, 190(1), e24–e27. https://doi.org/10.1111/bjh.16811

Li, Z.-A., & Lin, P. J. (2020). Factors Associated with Duration of Hospitalization in Patients with COVID-19. Biomedica, 36(4), 367–373. https://doi.org/10.51441/biomedica/5-81

Lippi, G., & Mattiuzzi, C. (2020). Hemoglobin value may be decreased in patients with severe coronavirus disease 2019. Hematology, Transfusion and Cell Therapy, 42(2), 116–117. https://doi.org/10.1016/j.htct.2020.03.001

Liu, G., Zhang, S., Hu, H., Liu, T. T., & Huang, J. (2020). The role of neutrophil-lymphocyte ratio and lymphocyte–monocyte ratio in the prognosis of type 2 diabetics with COVID-19. Scottish Medical Journal, 65(4), 154–160. https://doi.org/10.1177/0036933020953516

Liu, K., Fang, Y. Y., Deng, Y., Liu, W., Wang, M. F., Ma, J. P., Xiao, W., Wang, Y. N., Zhong, M. H., Li, C. H., Li, G. C., & Liu, H. G. (2020). Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chinese Medical Journal, 133(9), 1025–1031. https://doi.org/10.1097/CM9.0000000000000744

Liu, S., Luo, H., Wang, Y., Cuevas, L. E., Wang, D., Ju, S., & Yang, Y. (2020). Clinical characteristics and risk factors of patients with severe COVID-19 in Jiangsu province, China: A retrospective multicentre cohort study. BMC Infectious Diseases, 20(1), 1–9. https://doi.org/10.1186/s12879-020-05314-x

Okonkwo, I. N. C., Howie, A., Parry, C., Shelton, C. L., Cobley, S., Craig, R., Permall, N., El-Sheikha, S. H., Herbert, N., & Arnold, P. (2020). The safety of paediatric surgery between COVID-19 surges: an observational study. Anaesthesia, 75(12), 1605–1613. https://doi.org/10.1111/anae.15264

Oksuz, E., Malhan, S., Gonen, M. S., Kutlubay, Z., Keskindemirci, Y., & Tabak, F. (2021). COVID-19 healthcare cost and length of hospital stay in Turkey: retrospective analysis from the first peak of the pandemic. Health Economics Review, 11(1), 1–12. https://doi.org/10.1186/s13561-021-00338-8

Onder, G., Rezza, G., & Brusaferro, S. (2020). Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA - Journal of the American Medical Association, 323(18), 1775–1776. https://doi.org/10.1001/jama.2020.4683

Otros, T. O., Urbistondo, M. M., Vargas, A. M., Palomo, E. E., Miguel, M. A. De, Díaz, R. C., Daimiel, L., López, O. R., Cristóbal, R. S., Martínez, J. A., & Vargas, A. (2021). Nutrición Hospitalaria. 1–7.

Thiruvengadam, G., Lakshmi, M., & Ramanujam, R. (2021). A Study of Factors Affecting the Length of Hospital Stay of COVID-19 Patients by Cox-Proportional Hazard Model in a South Indian Tertiary Care Hospital. Journal of Primary Care and Community Health, 12. https://doi.org/10.1177/21501327211000231

Wu, S., Xue, L., Legido-Quigley, H., Khan, M., Wu, H., Peng, X., Li, X., & Li, P. (2020). Understanding factors influencing the length of hospital stay among non-severe COVID-19 patients: A retrospective cohort study in a Fangcang shelter hospital. PLoS ONE, 15(10 October), 1–14. https://doi.org/10.1371/journal.pone.0240959

Yao, Y., Cao, J., Wang, Q., Shi, Q., Liu, K., Luo, Z., Chen, X., Chen, S., Yu, K., Huang, Z., & Hu, B. (2020). D-dimer as a biomarker for disease severity and mortality in COVID-19 patients: A case control study. Journal of Intensive Care, 8(1), 1–11. https://doi.org/10.1186/s40560-020-00466-z

Yan, Y., Yang, Y., Wang, F., Ren, H., Zhang, S., Shi, X., Yu, X., & Dong, K. (2020). Clinical characteristics and outcomes of patients with severe covid-19 with diabetes. BMJ Open Diabetes Research and Care, 8(1), 1–9. https://doi.org/10.1136/bmjdrc-2020-001343




DOI: https://doi.org/10.33024/jikk.v9i3.7954

Refbacks

  • Saat ini tidak ada refbacks.


##submission.copyrightStatement##

##submission.license.cc.by-nc4.footer##

Pendidikan Dokter Universitas Malahayati Lampung


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.