ABSTRACT

 

Polycystic Ovary Syndrome (PCOS) is a collection of symptoms characterized by 3 (three) characteristics namely, increased androgen levels (hyperandrogenism), menstrual cycle irregularities, and small cysts on one or both ovaries. PCOS is the most common hormonal disorder affecting women of childbearing age. Hyperinsulinemia and insulin resistance are often associated with PCOS and become the main pathophysiology of this disease, where insulin functions to help regulate ovarian function by functioning as a cogonadotropin that will facilitate the secretion of androgen hormones from the adrenal glands and modulate the secretion of Luteinizing Hormone (LH) pulsatilely. There are various signs and symptoms of PCOS, including enlarged ovaries with many small cysts inside, irregular menstrual cycles, low back pain, hirsutism, alopecia, acne, acanthosis nigricans, skin tags. Laboratory investigations are needed to exclude other differential diagnoses as well as to see the levels of circulating androgen hormones in the blood. These include total and free testosterone, thyroid-stimulating hormone, prolactin, 17-hydroxyprogesterone, 2-hour post-prandial oral glucose tolerance test, fasting blood glucose, and lipid profile. After bromocriptine treatment, her prolactin levels decreased. The association of PCOS and hyperprolactinemia should be taken into account in cases of PCOS.

 

Keywords: PCOS, Hyperandrogenism, Hyperprolactinemia, Insulin Resistance

 

ABSTRAK

 

Polycystic Ovary Syndrome (PCOS) adalah kumpulan gejala yang dicirikan dengan 3 (tiga) karakteristik yaitu, peningkatan kadar androgen (hiperandrogenisme), irregularitas siklus menstruasi, dan kista kecil pada satu atau kedua ovarium. PCOS merupakan gangguan hormonal tersering yang menyerang Wanita Usia Subur (WUS). Hiperinsulinemia dan resistensi insulin sering dihubungkan dengan PCOS dan menjadi patofisiologi utama terjadinya penyakit ini, dimana insulin berfungsi untuk membantu regulasi fungsi ovarium dengan berfungsi sebagai cogonadotropin yang akan meemfasilitasi sekresi hormon androgen dari kelenjar adrenal dan memodulasi sekresi Luteinizing Hormone (LH) secara pulsatil. Terdapat berbagai macam tanda dan gejala PCOS, diantaranya adalah, pembesaran ovarium dengan banyak kista kecil didalamnya, siklus menstruasi yang tidak teratur, nyeri pinggang, hirsutisme, alopecia, acne, akantosis nigricans, skin tags. Pemeriksaan laboratorium diperlukan untuk mengeksklusi diagnosis banding yang lain serta melihat kadar hormon androgen yang bersirkulasi dalam darah. Pemeriksaan meliputi kadar testosterone total dan testosteron bebas, kadar Thyroid-Stimulating Hormone, prolaktin, 17-Hidroksiprogesterone, tes toleransi glukosa oral 2 jam post prandial, glukosa darah puasa, serta profil lipid. Setelah pengobatan bromokriptin, kadar prolaktinnya menurun. Hubungan PCOS dan hyperprolactinemia harus diperhitungkan pada kasus PCOS.

 

Kata Kunci: PCOS, Hiperandrogenisme, Hyperprolactinemia, Resisten Insulin

PCOS, hyperandrogenism, hyperprolactinemia, insulin resistance

Abrams E. Hormonal Imbalance And Hormone Regulated Issues. J Mol Pathophysiol. 2021;10(8). Majid S, Wani H, Khan A. Therapeutic Effects Of Nigella Sativa On Hormonal Dysfunctions. Researchgate. 2021;1(9):217–34.

Aulia, D. L. N., Risqi Utami, S. S. T., & Anjani, A. D. (2022). Komplikasi Pada Kehamilan, Persalinan, Nifas Dan Bayi Baru Lahir (Dilengkapi Latihan Soal Uji Kompetensi). Cv Pena Persada.

Fitria, S. (2016). Pengaruh Sindrom Polikistik Ovarium Terhadap Peningkatan Faktor Risiko Infertilitas. Medical Journal Of Lampung University, 5(2).

Harper-Harrison G, Shanahan M. Hormone Replacement Therapy. Nih. 2022.

I’tishom, R., & Pramesti, M. D. (2020). Biologi Reproduksi Pria. Airlangga University Press.

Khan R, Jiang X, Hameed U. Role Of Lipid Metabolism And Signaling In Mammalian Oocyte Maturation, Quality, And Acquisition Of Competence. Researchgate. 2021

Kurniati, M. (2021). Peran Aspek Genetik Sopk. Gracias Logis Kreatif.

Laven J. The Genetics Of Polycystic Ovary Syndrome: An Overview Of Candidate Gene Systematic Reviews And Genome-Wide Association Studies. Researchgate. 2019;8(10):1606.

Lee Tt, Rausch Me. Polycystic Ovarian Syndrome: Role Of Imaging In Diagnosis. Radiographics. 2012;32(6):1643–57.

Lividas S. Polycystic Ovary Syndrome: Definitions, Phenotypes And Diagnostic Approach. Researchgate. 2013.

Majid S, Wani H, Khan A. Therapeutic Effects Of Nigella Sativa On Hormonal Dysfunctions. Researchgate. 2021;1(9):217–34.

Mareta, R., Amran, R., & Larasati, V. (2018). Hubungan Polycystic Ovary Syndrome (Pcos) Dengan Infertilitas Di Praktik Swasta Dokter Obstetriginekologi Palembang. Majalah Kedokteran Sriwijaya, 50(2), 85-91.

Nurwati, I., & Ak, S. (2023). Akupunktur Pada Infertilitas Wanita. Cv. Mitra Cendekia Media.

Pertiwi, D. Y. P. (2018). Aplikasi Akupresur Pada Ny. N Dengan Ketidakefektifan Pemberian Asi Di Dusun Blanten Dukun Magelang (Doctoral Dissertation, Skripsi, Universitas Muhammadiyah Magelang).

Rasquin L, Anasthasopoulou C. Polycystic Ovarian Disease. Nih. 2022, Lividas S. Polycystic Ovary Syndrome: Definitions, Phenotypes And Diagnostic Approach. Researchgate. 2013.

Sen K, Gupta P, Talwar G. Intracellular Localization Of Estrogens In Chick Liver: Increase Of The Binding Sites For The Hormone On Repeated Treatment Of The Birds With The Hormone. 1975;6(8):1223–7.

Sirmans S, Pate K. Epidemiology, Diagnosis, And Management Of Polycystic Ovary Syndrome. Nih. 2014;(6):1–13.

Uche A, Eaton A, Green M. Polycystic Ovary Syndrome. Pubmed. 2013;38(6):336–8, 348, 355.

Witchel S, Oberfield S, Pena A. Polycystic Ovary Syndrome: Pathophysiology, Presentation, And Treatment With Emphasis On Adolescent Girls. Pubmed. 2019;3(8):1545–73.

Wiweko, B., & Mulya, R. (2008). Profil Resistensi Insulin Pada Pasien Sindrom Ovarium Polikistik (Sopk) Di Rs Dr. Cipto Mangunkusumo Jakarta. Indonesian Journal Of Obstetrics And Gynecology.