Hubungan Kadar HBA1C dan Insulin Puasa Terhadap Infeksi Saluran Kemih Pada Kelompok Lanjut Usia di Panti Santa Anna

Donatila Mano S, Zita Atzmardina, Alexander Halim Santoso, Fernando Nathaniel, Joshua Kurniawan, Dean Ascha Wijaya, Eric Raditya Kaminto, Andini Ghina Syarifah, Pasuarja Jeranding Ezra, Agnes Marcella, Rifi Nathaznya Syachputri

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ABSTRACT

 

Urinary tract infection (UTI) poses a serious concern in the elderly population, with approximately 25% of total infection cases in the geriatric group being UTIs. Diabetes mellitus stands as a leading cause of global morbidity and is associated with severe complications, including an increased risk of infections impacting the quality of life. Patients with diabetes face a twofold higher risk of mortality due to infections. Advanced age is also a risk factor for UTIs, influenced by factors such as uncontrolled diabetes. Measuring parameters such as fasting insulin and HbA1c levels is crucial for understanding correlation between diabetes and UTIs. HbA1c can reflect long-term glycemic control in diabetic patients. This cross-sectional study aims to investigate relationship between HbA1c and fasting insulin levels concerning the occurrence of UTIs in the elderly population, conducted at the Santa Anna Nursing Home in 2023. The study included 33 respondents with an average age of 72.88 years, predominantly comprising 24 female respondents (72.7%). The mean fasting insulin level was 12.46 mIU/mL, and HbA1c level was 5.97%. UTIs were diagnosed in 11 respondents (33.3%). The correlation analysis between these variables indicated no significant difference in the mean HbA1c levels between groups with or without UTIs (p = 0.955). However, a significant difference was observed in the mean fasting insulin levels between the two groups (p < 0.001). This finding is noteworthy as fasting insulin levels have a direct correlation with circulating blood glucose levels and formation of red blood cells, potentially influencing HbA1c levels. Further clarification is needed on how these three variables interact.

 

Keywords: Elderly, Fasting Insulin, HbA1c, Urinary Tract Infection

 

 

ABSTRAK

 

Infeksi saluran kemih (ISK) adalah masalah serius pada populasi lanjut usia, sekitar 25% dari total kasus infeksi pada kelompok geriatri adalah ISK. Diabetes melitus adalah penyebab utama morbiditas global dan berhubungan dengan komplikasi serius, termasuk risiko infeksi yang berdampak pada kualitas hidup. Pasien diabetes memiliki risiko dua kali lipat lebih tinggi untuk kematian akibat infeksi. Peningkatan usia juga merupakan faktor risiko untuk ISK, yang dipengaruhi oleh faktor-faktor seperti diabetes yang tidak terkontrol. Pengukuran parameter seperti insulin puasa dan HbA1c adalah kunci dalam memahami korelasi antara diabetes dan ISK. HbA1c dapat mencerminkan kontrol glikemik jangka panjang pada pasien diabetes. Penelitian potong lintang ini bertujuan untuk mengetahui hubungan antara kadar HbA1c dan insulin puasa terhadap kejadian ISK pada kelompok lanjut usia yang dilakukan di Panti Lansia Santa Anna pada tahun 2023. Penelitian mengikutsertakan 33 responden dengan rata-rata usia 72,88 tahun dan didominasi oleh jenis kelamin perempuan  sebanyak 24 responden (72,7%). Rerata kadar insulin puasa sebesar 12,46 mIU/mL dan kadar HbA1c sebanyak 5,97%. Sebanyak 11 responden (33,3%) terdiagnosis ISK. Hasil korelasi antara kedua variabel tersebut menunjukkan bahwa tidak ada perbedaan signifikan dalam rerata kadar HbA1c antara kelompok dengan atau tanpa ISK (p = 0,955). Meskipun demikian, terdapat perbedaan signifikan dalam rerata kadar insulin puasa antara kedua kelompok (p < 0,001). Hal ini menjadi sebuah pertimbangan karena kadar insulin puasa memiliki korelasi langsung dengan jumlah gula yang beredar bebas dalam darah dan pembentukan sel darah merah yang dapat meningkatkan tingkat HbA1c. Diperlukan penjelasan lebih lanjut tentang bagaimana ketiga variabel ini berinteraksi.

 

Kata Kunci: HbA1c, Infeksi Saluran Kemih, Insulin Puasa, Lanjut Usia


Kata Kunci


HbA1c; Infeksi saluran kemih; Insulin puasa; Lanjut usia

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DOI: https://doi.org/10.33024/mnj.v6i7.13510

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