Prevalensi Kelainan Kongenital Janin pada Kehamilan Penderita HIV/AIDS di RSUD Dr. Soetomo Kota Surabaya

Rista Elva Riani, Arief Bakhtiar, Dewi Setyowati, Manggala Pasca Wardhana, Tri Pudy Asmarawati

Sari


ABSTRACT

 

HIV infection in pregnancy is at risk of causing various complications in the mother and fetus, one of which is congenital abnormalities. This study aims to determine the prevalence of congenital abnormalities in pregnancy of women with HIV / AIDS. Retrospective descriptive study with cross-sectional design using medical record data of HIV-positive pregnant women at Dr. Soetomo Surabaya Hospital for the 2020-2022 period. There were 108 pregnant women with HIV, 3 of whom (2.8%) had congenital abnormalities in the fetus in the form of hydrocephalus, Dandy-Walker syndrome, and CPAM. Suspected to be associated with opportunistic infections and embryo-toxic effects of the ARV drug efavirenz. In pregnant women with HIV at Dr. Soetomo General Hospital, 3 (2.8%) pregnant women experience congenital abnormalities in the fetus, for that it is necessary to prevent and early detection of complications during pregnancy, as well as the selection of ARV regimens that are safer for fetal development.

 

Keywords: Pregnancy With HIV/AIDS, HIV/AIDS, Congenital Abnormalities

 

 

ABSTRAK

 

Infeksi HIV pada kehamilan berisiko menyebabkan berbagai komplikasi pada ibu dan janin, salah satunya kelainan bawaan. Penelitian ini bertujuan untuk mengetahui prevalensi kelainan bawaan pada kehamilan ibu dengan HIV/AIDS. Studi deskriptif retrospektif dengan desain cross-sectional menggunakan data rekam medis ibu hamil HIV-positif di RSUD Dr. Soetomo Surabaya periode 2020-2022. Ada 108 wanita hamil dengan HIV, 3 di antaranya (2,8%) memiliki kelainan bawaan pada janin berupa hidrosefalus, sindrom Dandy-Walker, dan CPAM. Diduga terkait dengan infeksi oportunistik dan efek toksik embrio dari obat ARV efavirenz. Pada ibu hamil dengan HIV di Rumah Sakit Umum Dr. Soetomo, 3 (2,8%) ibu hamil mengalami kelainan bawaan pada janin, untuk itu perlu dilakukan pencegahan dan deteksi dini komplikasi selama kehamilan, serta pemilihan regimen ARV yang lebih aman bagi perkembangan janin.

 

Kata Kunci: Kehamilan Dengan HIV/AIDS, HIV/AIDS, Kelainan Bawaan


Kata Kunci


kehamilan dengan HIV/AIDS, HIV/AIDS, kelainan bawaan

Teks Lengkap:

Download Artikel

Referensi


AmfAR. (2018). “Statistik: Perempuan Dan HIV/AIDS: Landasan Penelitian AIDS: Penelitian HIV/AIDS.” http://www.amfar.org/about-hiv-and-aids/facts-and-stats/statistics--women-and-hiv-aids/.

Blanco et al. (2010). “HIV-1 Infection: Viral Binding/Entry Inhibitors.” Chem Biol Drug Des, 76(2):85-9.

Cohn SE, Clark RA. (2015). “Infeksi Virus Imunodefisiensi Manusia Pada Wanita. Dalam: Prinsip Dan Praktik Penyakit Menular Mandell, Douglas, Dan Bennett, Edisi Terbaru. Edisi Ke-8. Philadelphia.” Elsevier/Saunders, 1590-1615.e10.

Correa GG, Amaral LF, Vedolin LM. (2011). “Neuroimaging Malformasi Dandy-Walker: Konsep Baru.” Pencitraan Resonansi Magn Teratas 22 :303–12.

Czeizel et al. (2013). “Association of Maternal Mycosis in Pregnancy with Congenital Abnormalities in Their Offspring.” Nutrition.

Ford et al. (2010). “Safety of Efavirenz in the First Trimester of Pregnancy: An Updated Systematic Review and Meta-Analysis.” AIDS.

Juanda, I. (2013). TORCH (Toxo,Rubella, CMV, Dan Herves) Akibat Dan Solusinya. Bogor: Yayasan Aqua Treatment.

Kementerian Kesehatan Republik Indonesia. (2019). “The Stategy and Policy to Involveproperty in Indonesia. In Germas.” Kementerian Kesehatan Republik Indonesia. 2 (2).

Khosravi N. (2002). “Atresia Choanal Bilateral Neonatal: Laporan Kasus.” Razi J Med Sci 9 :201–4.

Maartens et al. (2014). “HIV Infection: Epidemiology, Pathogenesis, Treatment, and Prevention.” Lancet 19;384(9939):258-71.

Mc Michael et al. (2010). “The Immune Response during Acute HIV-1 Infection: Clues for Vaccine Development.” Nat Rev Immunol 10(1):11-23.

McIntyre JA et al. (2019). “Mechanisms Underlying HIV-1 Mother-to-Child Transmission.” Sci Transl Med.

Minkoff et al. (1990). “Relationship of Cocaine Use during Pregnancy to Maternal HIV Infection and Perinatal Outcome.” AIDS 4(6):533-8.

Organisasi Kesehatan Dunia. (2018). “HIV/AIDS.” http://www.who.int/news-room/fact-sheets/detail/hiv-aids .

Puspitasari, R.S., Sucihati F, P. M. (2017). “Gambaran Peran Tenaga Kesehatan Terhadap Deteksi Dini TORCH Pada Kehamilan Di Puskesmas Sedayu Bantul.” Publikasi Alma Ata, 1–15.

Rumah Sakit Umum Daerah Dr. Soetomo. (2019). Rencana Strategis Tahun 2019-2024. Surabaya.

Sahu.SK, et.,al. (2019). “Seropravalence of TORCH Infection a Kimong Pregnant Woman.” International Jurnal Community Medicine and Public Health 6.5:2189.

Siregar, Yuniar. (2012). “Gambaran Kejadian Toxoplasmosis Di Yogayakarta.” Jurnal Veteriner 12 No 2Tahun 2012.

Stambolliu E, Ioakeim-Ioannidou M, Kontokostas K, Dakoutrou M, Kousoulis AA. (2017). “Komorbiditas Yang Paling Umum Pada Pasien Sindrom Dandy-Walker: Tinjauan Sistematis Terhadap Laporan Kasus.” J Anak Neurol 32 :886–902.

Stegmann BJ, Carey JC. (2002). “Infeksi TORCH (Toxoplasmosis, Sifilis, Varicella Zooster, Parvovirus B19, Rubella, Cytomegalovirus, Dan Infeksi Herpes).” Perwakilan Kesehatan Wanita 2:253-258.

Surya.i., Mulyana S., Pangkahila E., S. (2012). “Infection in Pregnancy. Infection in Pregnancies, CMV,” 113–25.

Sutton JB. (1887). “Relung Lateral Ventrikel Keempat: Hubungannya Dengan Kista Dan Tumor Tertentu Di Otak Kecil, Dan Meningokel Oksipital” 9 :352–61.

UNAIDS. (2021). “UNAIDS Data 2021.”

Watts DH. (2007). “Teratogenicity Risk of Antiretroviral Therapy in Pregnancy.” CURR HIV/AIDS.




DOI: https://doi.org/10.33024/mnj.v6i10.13807

Refbacks

  • Saat ini tidak ada refbacks.


Penerbit: Universitas Malahayati

 Creative Commons License

Semua artikel dapat digunakan dibawah lisensi Creative Commons Attribution-ShareAlike 4.0 International License