Efektivitas Niacinamide Topikal terhadap Hidrasi Kulit pada Individu dengan Akne Vulgaris

Nabila Jingga Permatasari, Sukmawati Tansil Tan

Sari


ABSTRACT

 

Nowadays, many skincare products use niacinamide as their base ingredient. Niacinamide, also known as vitamin B3, has the potential to enhance ceramide synthesis and improve the skin barrier function. Due to those potentials, niacinamide can improve someone’s skin hydration level. To find out the efficacy of topical niacinamide on skin hydration levels on individuals with acne vulgaris. Through a quasi-experimental study design, this study was conducted for 21 days at 75 North Jakarta State High School with respondents of 59 people who are suffering from acne vulgaris. The method that was used to collect the data involves measuring the level of skin hydration of the face before and after niacinamide serum intervention was given to respondents aged 15-18 years old. According to Wilcoxon’s statistic test, a significant change was achieved between the rate of skin hydration prior to and after intervention with niacinamide serum for 21 days (p-value < 0,001) with pre-evaluation values of 32% and after 41,5%. Topical use of niacinamide can increase someone’s skin hydration level.

 

Keywords: Niacinamide, Skin Hydration, Acne Vulgaris, Skincare

 

 

ABSTRAK

 

Dewasa ini, produk perawatan kulit banyak yang menggunakan niacinamide sebagai bahan dasarnya. Niacinamide atau vitamin B3 sendiri memiliki potensi untuk meningkatkan sintesis seramid dan memperbaiki fungsi penghalang kulit sehingga dapat meningkatkan hidrasi kulit. Untuk mencari efektivitas penggunaan niacinamide secara topikal terhadap tingkat hidrasi kulit pada individu dengan akne vulgaris. Melalui desain penelitian quasi-eksperimental, penelitian ini dilakukan selama 21 hari di SMA Negeri 75 Jakarta Utara dengan responden sebanyak 59 orang yang menderita akne vulgaris. Metode pengumpulan data melibatkan pengukuran tingkat hidrasi kulit wajah sebelum dan setelah pemberian intervensi serum niacinamide kepada responden berusia 15-18 tahun. Menurut uji statistik Wilcoxon didapatkan perubahan yang bermakna antara tingkat hidrasi kulit wajah sebelum dan sesudah intervensi dengan niacinamide selama 21 hari (P-value < 0,001) dengan rerata sebelum intervensi sebesar 32% dan sesudah sebesar 41,5%. Penggunaan niacinamide secara topikal dapat meningkatkan hidrasi kulit.

 

Kata Kunci: Niacinamide, Hidrasi Kulit, Akne Vulgaris, Perawatan Kulit


Kata Kunci


Niacinamide, hidrasi kulit, akne vulgaris, perawatan kulit

Teks Lengkap:

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Referensi


Berson, D. S., Osborne, R., Oblong, J. E., Hakozaki, T., Johnson, M. B., & Bissett, D. L. (2002). Niacinamide: A Topical Vitamin with Wide-Ranging Skin Appearance Benefits. Alternative Medicine Review, 7(6), 525–529. https://doi.org/10.3109/9781841847665-153

BLANK, I. H. (1952). Factors which influence the water content of the stratum corneum. The Journal of Investigative Dermatology, 18(6), 433–440. https://doi.org/10.1038/jid.1952.52

Caspers, P. J., Lucassen, G. W., & Puppels, G. J. (2003). Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin. Biophysical Journal, 85(1), 572–580. https://doi.org/10.1016/S0006-3495(03)74501-9

Christman, J. C., Fix, D. K., Lucus, S. C., Watson, D., Desmier, E., Wilkerson, R. J. J., & Fixler, C. (2012). Two randomized, controlled, comparative studies of the stratum corneum integrity benefits of two cosmetic niacinamide/glycerin body moisturizers vs. conventional body moisturizers. Journal of Drugs in Dermatology : JDD, 11(1), 22–29. http://www.ncbi.nlm.nih.gov/pubmed/22206073

De Oliveira, A. C., Morocho-Jácome, A. L., De Castro Lima, C. R., Marques, G. A., De Oliveira Bispo, M., De Barros, A. B., Costa, J. G., De Almeida, T. S., Rosado, C., De Carvalho, J. C. M., Velasco, M. V. R., & Baby, A. R. (2021). Cosmetics applications. Microalgae: Cultivation, Recovery of Compounds and Applications, 313–338. https://doi.org/10.1016/B978-0-12-821218-9.00010-4

Elias, P. M. (2008). Skin barrier function. Current Allergy and Asthma Reports, 8(4), 299–305. https://doi.org/10.1007/s11882-008-0048-0

Elizabeth, J., Tan, S. T., Angelika, M., Firmansyah, Y., Sylvana, Y., & Novendy, N. (2021). Penurunan Derajat Akne Vulgaris Setelah Penggunaan Kombinasi Krim Anti Akne Di Jakarta Barat. Jurnal Muara Sains, Teknologi, Kedokteran Dan Ilmu Kesehatan, 5(1), 19. https://doi.org/10.24912/jmstkik.v5i1.6625

Fonseca, A. P., Pizzol, C. D., Vanzo, A. C., da Silva, G. H., Facchini, G., Pinheiro, A. L. T. A., Eberlin, S., & Maia Campos, P. M. B. G. (2023). Antiaging effects of a skin care formulation containing nanoencapsulated antioxidants: A clinical, in vitro, and ex vivo study. Journal of Cosmetic Dermatology, July 2023, 510–524. https://doi.org/10.1111/jocd.15976

Fujii, M. (2021). The Pathogenic and Therapeutic Implications of Ceramide Abnormalities in Atopic Dermatitis. Cells, 10(9). https://doi.org/10.3390/cells10092386

Levin, J., & Momin, S. B. (2010). How much do we really know about our favorite cosmeceutical ingredients? The Journal of Clinical and Aesthetic Dermatology, 3(2), 22–41. http://www.ncbi.nlm.nih.gov/pubmed/20725560

Matts, P. J., Oblong, J. E., & Bissett, D. L. (2002). A Review of The Range of Effects of Niacinamide in Human Skin. IFSCC Magazine, 5(January 2002), 285–289. https://www.researchgate.net/publication/286270242

Mizwar, M., Kapantow, M. G., & Suling, P. L. (2013). Profil Akne Vulgaris di RSUP Prof. Dr. R. D. Kandou Manado Periode 2009-2011. E-CliniC, 1(2). https://doi.org/10.35790/ecl.1.2.2013.3276

Mohammed, D., Crowther, J. M., Matts, P. J., Hadgraft, J., & Lane, M. E. (2013). Influence of niacinamide containing formulations on the molecular and biophysical properties of the stratum corneum. International Journal of Pharmaceutics, 441(1–2), 192–201. https://doi.org/10.1016/j.ijpharm.2012.11.043

Murphrey, M. B., Miao, J. H., & Zito, P. M. (2024). Histology, Stratum Corneum. In StatPearls. http://www.ncbi.nlm.nih.gov/pubmed/21663940

Offerta, A., Bonina, F., Gasparri, F., Zanardi, A., Micicche, L., & Puglia, C. (2016). In vitro Percutaneous Absorption of Niacinamide and Phytosterols and in vivo Evaluation of their Effect on Skin Barrier Recovery. Current Drug Delivery, 13(1), 111–120. https://doi.org/10.2174/1567201812666150722123218

Palma, L., Marques, L. T., Bujan, J., & Rodrigues, L. M. (2015). Dietary water affects human skin hydration and biomechanics. Clinical, Cosmetic and Investigational Dermatology, 8, 413–421. https://doi.org/10.2147/CCID.S86822

Ra, Y., Ht, S., & Dn, F. (2013). Quality of Life of Acne Vulgaris Patient in DR . H . Abdul Moeloek Hospital at Lampung Kualitas hidup pada pasien Akne Vulgaris di RSUD DR . H . Abdul Moeloek Lampung. Universitas Lampung, 139–145.

Rosso, J. Del, Zeichner, J., Alexis, A., Cohen, D., & Berson, D. (2016). Understanding the Epidermal Barrier in Healthy and Compromised Skin: Clinically Relevant Information for the Dermatology Practitioner: Proceedings of an Expert Panel Roundtable Meeting. The Journal of Clinical and Aesthetic Dermatology, 9(4 Suppl 1), S2–S8. http://www.ncbi.nlm.nih.gov/pubmed/28936279

Sari, A. R., Ramadhanty, P. K., Anggraeni, N., Destra, E., & Firmansyah, Y. (2023). Exploring the Connection Between Facial Skin Cleansing Habits and Acne Vulgaris: A Comprehensive Review. Medicor : Journal of Health Informatics and Health Policy, 1(1), 25–30. https://doi.org/10.61978/medicor.v1i1.42

Sastroasmoro, S., & Ismael, S. (2008). Dasar-Dasar Metodologi Penelitian Klinis.

Sutaria, A. H., Masood, S., Saleh, H. M., & Schlessinger, J. (2024). Acne Vulgaris. In StatPearls. http://www.ncbi.nlm.nih.gov/pubmed/30101990

Tan, S., Firmansyah, Y., Elizabeth, J., & Angelika, M. (2020). Tingkatkan Kepercayaan Diri Remaja Dengan Mengontrol Acne. https://doi.org/10.13140/RG.2.2.16187.23846

Tan, S. T., & Firmansyah, Y. (2021). New Drug Formulations For Acne Vulgaris-Pathogenesis Based Treatment Of Acne Vulgaris. Jurnal Medika Hutama, 2(04 Juli), 1021–1026. https://jurnalmedikahutama.com/index.php/JMH/article/view/206

Tanno, O., Ota, Y., Kitamura, N., Katsube, T., & Inoue, S. (2000). Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. British Journal of Dermatology, 143(3), 524–531. https://doi.org/10.1111/j.1365-2133.2000.03705.x

Verdier-Sévrain, S., & Bonté, F. (2007). Skin hydration: a review on its molecular mechanisms. Journal of Cosmetic Dermatology, 6(2), 75–82. https://doi.org/10.1111/j.1473-2165.2007.00300.x

Voegeli, R., Guneri, D., Cherel, M., Summers, B., Lane, M. E., & Rawlings, A. V. (2020). Topical niacinamide enhances hydrophobicity and resilience of corneocyte envelopes on different facial locations. International Journal of Cosmetic Science, 42(6), 632–636. https://doi.org/10.1111/ics.12666

Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., Abraham, J., Ackerman, I., Aggarwal, R., Ahn, S. Y., Ali, M. K., AlMazroa, M. A., Alvarado, M., Anderson, H. R., Anderson, L. M., … Murray, C. J. (2012). Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet, 380(9859), 2163–2196. https://doi.org/10.1016/S0140-6736(12)61729-2

Yolanda, M. O., Jusuf, N. K., & Putra, I. B. (2021). Lower facial skin hydration level increases acne vulgaris severity level. Bali Medical Journal, 10(3), 1081–1084. https://doi.org/10.15562/bmj.v10i3.2195




DOI: https://doi.org/10.33024/mnj.v6i12.15839

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