Efek Potensial Moringa Oleifera pada Infeksi COVID-19

Lusi Nursilawati Syamsi, Dian Ratih, Syamsudin Abidillah

Sari


ABSTRACT

 

The COVID 19 pandemic is an outbreak caused by the coronavirus disease 2019 (COVID-19) with clinical manifestations of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which has caused a large number of deaths worldwide. The most common complications of COVID-19 are cardiovascular and kidney disorders. The urgency to develop natural medicines with natural ingredients that are effective against COVID-19 is very important to maintain body immunity and at the same time protect the body from close contact with sufferers of COVID-19. Moringa plants have the potential to increase the body's resistance (immune booster) of sufferers against SARS-CoV-2. (COVID-19) and moringa plants have other health functions such as anti-inflammatory, antimicrobial, antidiabetic, antioxidant, antitumor, anticancer, antihypertensive, antiasthma, anticoagulation, antiurolithiasis, anthelmintic, antifertility, antihyperthyroid, and antialzheimer's. Several components of Moringa that play a role in the antiviral COVID-19 are Kaempferol, Pterygospermin, Morphine, Quercetin, and Apigenin-7-O-rutinoside. This Literature Review provides a basis for further research on the development of clinical applications of Moringa Oleifera for the treatment of SARS-CoV-2.

 

Keywords: Covid-19, Potential Effects, Literature Review

 

 

ABSTRAK

 

Pandemi COVID 19 adalah wabah yang disebabkan penyakit coronavirus 2019 (COVID-19) dengan manisfestasi klinis sindrom pernapasan akut coronavirus 2 (SARS-CoV-2) yang menyebabkan kematian yang cukup besar di seluruh dunia. Komplikasi tersering COVID-19 adalah gangguan kardiovaskular dan ginjal. Urgensi mengembangkan pengobatan natural bahan alam yang mempunyai efektivitas terhadap COVID 19 menjadi sangat penting untuk menjaga imunitas tubuh dan sekaligus menjaga tubuh terhadap kontak erat penderita COVID 19. Tanaman kelor mempunyai potensi meningkatkan daya tahan tubuh (booster imun )penderita terhadap penyakit SARS-CoV-2 (COVID 19) dan tanaman kelor memiliki fungsi Kesehatan lainnya seperti antiradang, antimikroba, antidiabetes, antioksidan, antitumor, antikanker, antihipertensi, antiasma, antikoagulasi, antiurolitiasis, anthelmintik, antifertilitas, antihipertiroid, dan antialzheimer. Beberapa komponen kelor yang berperan pada antivirus COVID-19 adalah Kaempferol, Pterygospermin, Morfin, Quercetin, dan Apigenin-7-O-rutinoside. Tinjauan Pustaka ini memberikan dasar untuk penelitian lebih lanjut pengembangan aplikasi klinis Moringa Oleifera untuk pengobatan SARS-CoV-2.

 

Kata Kunci: Covid-19, Efek Potensial, Tinjauan Pustaka


Teks Lengkap:

Download Artikel

Referensi


Aguirre L, Arias N, Macarulla MT, Gracia A, Portillo MP. (2011). Beneficial effects of quercetin on obesity and diabetes. Open Nutraceuticals Journal. (1):189–98.

Anand David AV, Arulmoli R, Parasuraman S. (2016). Overviews of biological importance of quercetin: A bioactive flavonoid. Pharmacognosy Reviews. (20):84–9.

Ather Prof EM. DrA, Costigliola V. (2020). Treatment and Control of Covid-19 (Corona Virus Disease 2019) By Non-invasive (h.i.p) Non-drug Therapy in Combination Anti-influenza an (Oseltamivir (rx) Tamiflue) Drug-Novel Case Report. SSR Institute of International Journal of Life Sciences. (2):2480–6.

Augustus Obi JNE, , S. O. Ojefa, M. C. Ohamaeme2 , C. N. Ekweogu3 FUO.(2018). Immunomodulatory Effects of Hydromethanolic Extract of. Journal of Experimental and Clinical Biosciences. 6:26–32.

Chen X, Wang Z, Yang Z, Wang J, Xu Y, Tan R xiang, et al. (2011). Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation. Antiviral Research.;92(2):341–5.

Choi JH, Kim KJ, Kim S. (2016) Comparative Effect of Quercetin and Quercetin-3-O-β-d-Glucoside on Fibrin Polymers, Blood Clots, and in Rodent Models. Journal of Biochemical and Molecular Toxicology.;30(11):548–58.

Covid- T.(2020). COVID-19 and the Brain – Pathogenesis and Neuropsychiatric Manifestations of SARS-CoV-2 CNS Involvement.

D, Athira Nair; J JT.(2020). Computational screening of phytocompounds from Moringa oleifera leaf as potential inhibitors of SARS-CoV-2 Mpro. Research Square. 1–14.

Dabeek WM, Marra M v. (2019). Dietary quercetin and kaempferol: bioavailability in humans. Nutrients. 11:2288.

Derosa G, Maffioli P, D’Angelo A, di Pierro F.(2021) A role for quercetin in coronavirus disease 2019 (COVID-19). Phytotherapy Research.;35(3):1230–6.

Dhakar R, Pooniya B, Gupta M, Maurya S, Bairwa N, Sanwarmal.(2011). Moringa : The herbal gold to combat malnutrition. Chronicles of Young Scientists. 2(3):119.

Esposito G, Pesce M, Seguella L, Sanseverino W, Lu J, Sarnelli G.(2020). Can the enteric nervous system be an alternative entrance door in SARS-CoV2 neuroinvasion? Brain, Behavior, and Immunity [Internet]. 87(April):93–4. Available from: https://doi.org/10.1016/j.bbi.2020.04.060

Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection.(2020);(January).

Fajri M. (2021). The potential of Moringa oleifera as immune booster against COVID 19. IOP Conference Series: Earth and Environmental Science.;807(2):1–5.

Gu Y-Y, 1☯ ID, Zhang M, Cen H, Wu Y-F, Lu Z, et al.(2021). Quercetin as a potential treatment for COVID-19-induced acute kidney injury: Based on network pharmacology and molecular docking study.; Available from: https://doi.org/10.1371/journal.pone.0245209.g001

Heinz SA, Henson DA, Austin MD, Jin F, Nieman DC. (2010). Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial. Pharmacological Research.;62(3):237–42.

Ingestion. (2014). Quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans.

Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, et al. (2021). new data content and improved web interfaces. Nucleic Acids Research [Internet]. 2021;49. Available from: https://pubchem.ncbi.nlm.nih.gov/pathway/Reactome:R-BTA-177929

Lakhanpal P, Rai DK. (2007). Quercetin: A Versatile Flavonoid. Internet Journal of Medical Update - EJOURNAL; 2(2).

Larson AJ, David Symons J, Jalili T.(2012). Therapeutic potential of quercetin to decrease blood pressure: Review of efficacy and mechanisms. Advances in Nutrition. 3(1):39–46.

Li S, Tan HY, Wang N, Cheung F, Hong M, Feng Y.(2020). The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases. Oxidative Medicine and Cellular Longevity.

Lin L, Lu L, Cao W, Li T.(2020). Hypothesis for potential pathogenesis of SARS-CoV-2 infection–a review of immune changes in patients with viral pneumonia. Emerging Microbes and Infections. 9(1):727–32.

Luo E, Zhang D, Luo H, Liu B, Zhao K, Zhao Y, et al.(2020). Treatment efficacy analysis of traditional Chinese medicine for novel coronavirus pneumonia (COVID-19): An empirical study from Wuhan, Hubei Province, China. Chinese Medicine (United Kingdom) [Internet]. 15(1):1–13. Available from: https://doi.org/10.1186/s13020-020-00317-x

Mosawy S. (2015). Effect of the flavonol quercetin on human platelet function: A review. Food and Public Health. 5(1):1–9.

Nfambi J, Bbosa GS, Sembajwe LF, Gakunga J, Kasolo JN. Immunomodulatory activity of methanolic leaf extract of Moringa oleifera in Wistar albino rats.

Nursilawati Syamsi L, Amin C, Andayani N, Abdillah S. the .(2021). Effectiveness of Poly-Herbal As Adjuvants for the Standard Treatment of Covid 19 in Patients With Moderate Degree of Sars Cov2 Based on Clinical and Laboratory Symptoms. European Journal of Molecular & Clinical Medicine. 08(03).

Palghadmal SB, Kulkarni PS, Makadia V, Deshmukh MJ, Gondhale PS, Padmanabhan S.(2021) Tackling Complications of Coronavirus Infection with Quercetin: Observations and Hypotheses. Exploratory Research and Hypothesis in Medicine. 000(000):000–000.

Pandey AT, Pandey I, Zamboni P, Gemmati D, Kanase A, Singh AV, et al.(2019) Traditional Herbal Remedies with a Multifunctional Therapeutic Approach as an Implication in COVID-19 Associated Co-Infections. Available from: www.mdpi.com/journal/coatings

Peneliti BB Pascapanen.(2020). Bahan Pangan Potensial untuk Anti Virus dan Imun Booster. Bahan Pangan Potensial untuk Anti Virus dan Imun Booster. 1–103 p.

Rastogi S, Narayan D, Harsh R.(2020). COVID-19 pandemic: A pragmatic plan for ayurveda intervention. Journal of Ayurveda and Integrative Medicineverda. January).

Rastogi S, Pandey DN, Singh RH. (2020). COVID-19 pandemic: A pragmatic plan for ayurveda intervention. Journal of Ayurveda and Integrative Medicine [Internet]. 2020;(xxxx):100312. Available from: https://doi.org/10.1016/j.jaim..04.002

Saeedi-Boroujeni A, Mahmoudian-Sani MR. (2021). Anti-inflammatory potential of Quercetin in COVID-19 treatment. Journal of Inflammation (United Kingdom). 18(1):1–9.

Sankhalkar S, Vernekar V. (2016). Quantitative and Qualitative Analysis of Phenolic and Flavonoid Content in Moringa oleifera Lam and Ocimum tenuiflorum L.; Available from: www.phcog.net

Schwarz S, Sauter D, Wang K, Zhang R, Sun B, Karioti A, et al.(2014). Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus. Planta Medica. 80(2–3):177–82.

Sengupta B, Sengupta PK. (2003). Binding of Quercetin with Human Serum Albumin: A Critical Spectroscopic Study. Biopolymers - Biospectroscopy Section. 72(6):427–34.

Shaji D. (2020). Computational Identification of drug lead compounds for COVID-19 from Moringa Oleifera. ChemRxiv.

Syamsi LN, Amin C, Andayani N, Abdillah S.(2021). The effect of adjuvant therapy with polyherbal formulas on improving the mmrc score of patients with moderate-grade sars cov-2 pneumonia. Teikyo Medical Journal. 44(4):949–56.

Vaneková Z, Hubčík L, Toca-Herrera JL, Furtm uller PG, Mučaji P, Nagy M.(2020). Analysis of binding interactions of ramipril and quercetin on human serum albumin: A novel method in affinity evaluation. Molecules. 25(3):1–17.

Wardhani TM. (2020).Sebagai Sumber Terapi Preventif dan Kuratif pada Pasien Perlemakan Hati dengan Sindrom Metabolik. 1:1–11.

Yeon MJ, Lee MH, Kim H, Yang JY, Woo HJ, Kwon HJ, et al. (2018). Anti-inflammatory effects of Kaempferol on Helicobacter pylori-induced inflammation. Available from: https://doi.org/10.1080/09168451.2018.1528140

Zhu J, Ji P, Pang J, Zhong Z, Li H, He C, et al. (2020). Clinical characteristics of 3,062 COVID-19 patients: a meta-analysis. Journal of Medical Virology. March):1–13.




DOI: https://doi.org/10.33024/mnj.v5i3.8144

Refbacks

  • Saat ini tidak ada refbacks.


Penerbit: Universitas Malahayati

 Creative Commons License

Semua artikel dapat digunakan dibawah lisensi Creative Commons Attribution-ShareAlike 4.0 International License