STUDI BIOINFORMATIKA KONSTITUEN MAYOR Centella asiatica DALAM MEMODULASI KECEMASAN DAN DEPRESI

Vania Amanda Samor, Rachmi Nurkhalika, Yovita Endah Lestari, Saddam Husein

Abstract


Konstituen mayor Centella asiatica (CA) memiliki banyak manfaat farmakologis dan diduga dapat mempengaruhi kondisi kecemasan dan depresi, namun jalur persinyalan molekuler belum sepenuhnya dipahami. Studi ini bertujuan untuk mengeksplorasi target potensial mekanisme konstituen mayor melalui pendekatan bioinformatika. Prediksi protein yang dimodulasi oleh konstituen mayor CA dilakukan dengan SwissTargetPrediction 2019 dan STITCH 5.0 yang kemudian dilakukan analisis irisan dengan gen depresi dan kecemasan yang diperoleh dari GeneCards. Analisis interaksi protein-protein dilakukan dengan STRING 11.5 dan ditelusuri ketermungkinan jalur persinyalan gen dengan WebGestalt 2019. Melalui studi diketahui bahwa konstituen mayor CA (asiaticoside) berpotensi memodulasi kondisi kecemasan dan depresi melalui jalur persinyalan BDNF. Studi lebih lanjut diperlukan untuk mengeksplorasi potensi terapi konstituen mayor CA dengan model depresi dan kecemasan.

Keywords


centella asiatica, depresi, kecemasan, studi bioinformatika

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DOI: https://doi.org/10.33024/jmm.v7i4.12752

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