Effectiveness of Platelet Transfusion in Dengue Fever Patients: A Systematic Review

Ninu Desyarni, Endang Triyanto

Sari


ABSTRACT

 

Dengue fever is a global health concern characterized by severe thrombocytopenia and an increased risk of bleeding. Platelet transfusion is often used to manage thrombocytopenia, but its effectiveness remains uncertain. This review aims to evaluate the efficacy of platelet transfusion in preventing bleeding and improving clinical outcomes among dengue fever patients. A systematic search was conducted across PubMed, ScienceDirect, and Google Scholar using keywords such as “platelet transfusion,” “dengue fever,” and “thrombocytopenia.” Nine studies, including randomized controlled trials and observational studies, were analyzed for outcomes related to bleeding incidence, platelet recovery, and hospitalization duration. The findings indicate that prophylactic platelet transfusion does not significantly reduce bleeding incidence or improve recovery rates in dengue patients. It may be associated with delayed platelet recovery, prolonged hospitalization, and increased risk of adverse events.

 

Keywords: Dengue Fever, Platelet Transfusion, Thrombocytopenia, Bleeding, Hospitalization.


Referensi


Archuleta, S., Chia, P. Y., Wei, Y., Syed-Omar, S. F., Low, J. G., Oh, H. M., Fisher, D., Ponnampalavanar, S. S. L., Wijaya, L., Kamarulzaman, A., Lum, L. C. S., Tambyah, P. A., Leo, Y. S., & Lye, D. C. (2020). Predictors And Clinical Outcomes Of Poor Platelet Recovery In Adult Dengue With Thrombocytopenia: A Multicenter, Prospective Study. Clinical Infectious Diseases, 71(2), 383–389. Https://Doi.Org/10.1093/Cid/Ciz850

Andriastuti, M., Chozie, N. A., & Rahmani, S. Laporan Kasus Berbasis Bukti Efektivitas Transfusi Trombosit Hasil Uji Silang Serasi (Crossmatch) Pada Kondisi Trombositopenia Refrakter.

Asmarani, E. (2021). Penatalaksanaan Trombositopenia Pada Pasien Dengue Hemorrhagic Fever (Doctoral Dissertation, Stikes Insan Cendekia Medika Jombang).

Assir, M. Z. K., Kamran, U., Ahmad, H. I., Bashir, S., Mansoor, H., Anees, S. Bin, & Akram, J. (2013). Effectiveness Of Platelet Transfusion In Dengue Fever: A Randomized Controlled Trial. Transfusion Medicine And Hemotherapy, 40(5), 362–368. Https://Doi.Org/10.1159/000354837

Barker, T. H., Stone, J. C., Sears, K., Klugar, M., Tufanaru, C., Leonardi-Bee, J., Aromataris, E., & Munn, Z. (2023). The Revised Jbi Critical Appraisal Tool For The Assessment Of Risk Of Bias For Randomized Controlled Trials. Jbi Evidence Synthesis, 21(3), 494–506. Https://Doi.Org/10.11124/Jbies-22-00430

Bhat, A., Chowdappa, V., & Masamatti, S. S. (2016). Effectiveness Of Pooled Platelet Transfusion In Concordant And Discordant Groups Among Dengue Patients. Journal Of Clinical And Diagnostic Research, 10(7), Ec21–Ec24. Https://Doi.Org/10.7860/Jcdr/2016/19278.8213

Chaudhary, R., Khetan, D., Sinha, S., Sinha, P., Sonker, A., Pandey, P., ... & Ray, V. (2006). Transfusion Support To Dengue Patients In A Hospital Based Blood Transfusion Service In North India. Transfusion And Apheresis Science, 35(3), 239-244.

Kaur, P., & Kaur, G. (2014). Transfusion Support In Patients With Dengue Fever. International Journal Of Applied And Basic Medical Research, 4(3), 8. Https://Doi.Org/10.4103/2229-516x.140708

Lee, T. H., Wong, J. G. X., Leo, Y. S., Thein, T. L., Ng, E. L., Lee, L. K., & Lye, D. C. (2016). Potential Harm Of Prophylactic Platelet Transfusion In Adult Dengue Patients. Plos Neglected Tropical Diseases, 10(3), 1–10. Https://Doi.Org/10.1371/Journal.Pntd.0004576

Lye, D. C., Archuleta, S., Syed-Omar, S. F., Low, J. G., Oh, H. M., Wei, Y., Fisher, D., Ponnampalavanar, S. S. L., Wijaya, L., Lee, L. K., Ooi, E. E., Kamarulzaman, A., Lum, L. C., Tambyah, P. A., & Leo, Y. S. (2017). Prophylactic Platelet Transfusion Plus Supportive Care Versus Supportive Care Alone In Adults With Dengue And Thrombocytopenia: A Multicentre, Open-Label, Randomised, Superiority Trial. The Lancet, 389(10079), 1611–1618. Https://Doi.Org/10.1016/S0140-6736(17)30269-6

Lye, D. C., Lee, V. J., Sun, Y., & Leo, Y. S. (2009). Lack Of Efficacy Of Prophylactic Platelet Transfusion For Severe Thrombocytopenia In Adults With Acute Uncomplicated Dengue Infection. Clinical Infectious Diseases, 48(9), 1262–1265. Https://Doi.Org/10.1086/597773

Machado, A. A. V., Negrao, F. J., Croda, J., De Medeiros, E. S., & Pires, M. A. D. S. (2019). Safety And Costs Of Blood Transfusion Practices In Dengue Cases In Brazil. Plos One, 14(7), 1–14. Https://Doi.Org/10.1371/Journal.Pone.0219287

Manoharan, A., Janarthanam, V., Srivastava, R., Sowmya, S., & Gandhi, N. (2016). Effectiveness Of Platelet Transfusion In Dengue Fever. Int J Res Rev, 3, 5-9.

Makroo, R. N., Raina, V., Kumar, P., & Kanth, R. K. (2007). Role Of Platelet Transfusion In The Management Of Dengue Patients In A Tertiary Care Hospital. Asian Journal Of Transfusion Science, 1(1), 4-7.

Newland, A., Bentley, R., Jakubowska, A., Liebman, H., Lorens, J., Peck-Radosavljevic, M., Taieb, V., Takami, A., Tateishi, R., & Younossi, Z. M. (2019). A Systematic Literature Review On The Use Of Platelet Transfusions In Patients With Thrombocytopenia. Hematology (United Kingdom), 24(1), 679–719. Https://Doi.Org/10.1080/16078454.2019.1662200

Prashantha, B., Varun, S., Sharat, D., Murali Mohan, B. V., Ranganatha, R., Shivaprasad, & Naveen, M. (2014). Prophyactic Platelet Transfusion In Stable Dengue Fever Patients: Is It Really Necessary?. Indian Journal Of Hematology And Blood Transfusion, 30, 126-129.

Ypma, P. F., Van Der Meer, P. F., Heddle, N. M., Van Hilten, J. A., Stijnen, T., Middelburg, R. A., Hervig, T., Van Der Bom, J. G., Brand, A., & Kerkhoffs, J. L. H. (2016). A Study Protocol For A Randomised Controlled Trial Evaluating Clinical Effects Of Platelet Transfusion Products: The Pathogen Reduction Evaluation And Predictive Analytical Rating Score (Prepares) Trial. Bmj Open, 6(1), 1–12. Https://Doi.Org/10.1136/Bmjopen-2015-010156




DOI: https://doi.org/10.33024/mahesa.v5i8.18717

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