Role of Dermatoporosis as Mediating Factors: Impact of Systemic Health Parameters on Dermatology Life Quality Index in The Elderly

Linda Julianti W., Edwin Destra, Yohanes Firmansyah, Catharina Sagita Moniaga, Sukmawati Tansil Tan, Bryan Anna Wijaya, Farell Christian Gunaidi

Sari


ABSTRACT

 

Dermatoporosis, an emerging concern in geriatric dermatology characterized by pronounced skin fragility and chronic skin atrophy, significantly impacts the quality of life among the elderly. This study delves into the complex interactions between various health parameters such as albumin, glucose, lipid profiles, uric acid, vitamin D, insulin resistance, uric acid, renal functions, and liver functions, assessing their cumulative effect on the Dermatology Life Quality Index (DLQI) in an elderly population, with dermatoporosis serving as a pivotal mediating factor. This study included 31 individuals who met the specified inclusion criteria. The selection process was designed to ensure the relevance of analyzed health parameters and to minimize selection bias, thereby enhancing the validity and applicability of the findings. Descriptive and inferential statistical methods were employed, along with Partial Least Squares (PLS) path modeling, to control for potential confounding variables and explore the multifactorial relationships among the measured variables. Regression analysis indicated that dermatoporosis significantly mediates the relationship between these health parameters and the DLQI, evidenced by R² values of 0.691 for dermatoporosis and 0.842 for DLQI. This study confirms that skin health in the elderly is multifactorial and strongly influenced by systemic health parameters. A multidisciplinary approach is essential to holistically manage dermatological conditions, addressing not only skin symptoms, but also systemic health factors that exacerbate skin disorders and diminish the quality of life in older adults.

 

Keywords: Dermatoporosis, Dermatology Life Quality Index (DLQI), Geriatric Dermatology, Health Parameters, Systemic Health Influences.


Referensi


Ahmed, H. B., Lal, D. M., Pirzado, M. S., Rashid, A., Anwar, I., & Malkani, S. (2019). Serum uric acid concentration (SUAC): A useful tool to assess extent and severity of chronic plaque psoriasis in Pakistani population. The Professional Medical Journal, 26(11), 1825–1828. https://doi.org/10.29309/TPMJ/2019.26.11.692

Alkammaz, A. M. G., & Stepanenko, R. L. (2020). The role of lipoprotein spectrum indices in the pathogenesis of psoriasis. Ukrainian Journal of Dermatology, Venerology, Cosmetology, 4, 6–11. https://doi.org/10.30978/UJDVK2020-4-6

Avis, K. A., Stroebe, M., & Schut, H. (2021). Stages of Grief Portrayed on the Internet: A Systematic Analysis and Critical Appraisal. Frontiers in Psychology, 12. https://doi.org/10.3389/FPSYG.2021.772696/FULL

Baciur, P., Chmura, A., Skowrońska, K., Białas, F., & Pondel, K. (2022). role of Vitamin D in the prevention and treatment of inflammatory skin diseases – atopic dermatitis and psoriasis - literature review. Journal of Education, Health and Sport, 12(8), 1156–1163. https://doi.org/10.12775/JEHS.2022.12.08.099

Behera, P. R., Palepu, S., Sirka, C. S., Ranjan, R., Pradhan, S., & Singh, A. K. (2022). Psychosocial Distress and Quality of Life Among Patients With a Chronic Skin Disorder at a Tertiary Care Hospital in Eastern India: A Hospital-Based Case-Control Study. Cureus. https://doi.org/10.7759/cureus.29830

Bhandari, A., & Mahajan, R. (2022). Skin Changes in Cirrhosis. Journal of Clinical and Experimental Hepatology, 12(4), 1215–1224. https://doi.org/10.1016/j.jceh.2021.12.013

Bruckner-Tuderman, L. (2020). Skin Fragility: Perspectives on Evidence-based Therapies. Acta Dermato Venereologica, 100(5), adv00053-101. https://doi.org/10.2340/00015555-3398

Castillo-Cruz, U. del R., Cortés-García, J. D., Castanedo-Cazares, J. P., Hernández-Blanco, D., & Torres-Álvarez, B. (2023). Factors associated with dermatoporosis in a sample of geriatric patients in Mexico. Gaceta de Mexico, 159(1). https://doi.org/10.24875/GMM.M22000737

Curry, K., Kutash, M., Chambers, T., Evans, A., Holt, M., & Purcell, S. (2012). A prospective, descriptive study of characteristics associated with skin failure in critically ill adults. Ostomy/Wound Management, 58(5), 36–38, 40–43.

Dyer, J. M., & Miller, R. A. (2018). Chronic Skin Fragility of Aging: Current Concepts in the Pathogenesis, Recognition, and Management of Dermatoporosis. The Journal of Clinical and Aesthetic Dermatology, 11(1), 13–18. http://www.ncbi.nlm.nih.gov/pubmed/29410724

El Mongy, N., & Hilal, R. (2023). Vitamin D and the skin: an immunologic and therapeutic update. Journal of the Egyptian Women’s Dermatologic Society, 20(2), 69. https://doi.org/10.4103/jewd.jewd_55_22

FINLAY, A. Y., & KHAN, G. K. (1994). Dermatology Life Quality Index (DLQI)-a simple practical measure for routine clinical use. Clinical and Experimental Dermatology, 19(3), 210–216. https://doi.org/10.1111/j.1365-2230.1994.tb01167.x

Gerber, P. A., Buhren, B. A., Schrumpf, H., Hevezi, P., Bölke, E., Sohn, D., Jänicke, R. U., Belum, V. R., Robert, C., Lacouture, M. E., & Homey, B. (2016). Mechanisms of skin aging induced by EGFR inhibitors. Supportive Care in Cancer, 24(10), 4241–4248. https://doi.org/10.1007/s00520-016-3254-7

Goyal, M., & Kedia, A. K. (2022). Vitamin D and Aging: An Interplay of Multiple Mechanisms. Anti-Aging Eastern Europe. https://doi.org/10.56543/aaeeu.2022.1.1.08

Guadanhim, L. R. S., Miot, H. A., Soares, J. L. M., Silva, S. A. M., Leonardi, G. R., Lopes, R. D., & Bagatin, E. (2023). Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study. Dermatology and Therapy, 13(2), 523–534. https://doi.org/10.1007/s13555-022-00859-y

He, X., Gao, X., & Xie, W. (2023). Research Progress in Skin Aging, Metabolism, and Related Products. International Journal of Molecular Sciences, 24(21), 15930. https://doi.org/10.3390/ijms242115930

Hernández-Collazo, A. A., Villanueva-Quintero, G., Rodríguez- Castellanos, M. A., Poletti-Vázquez, E. D., & Alvarado-Navarro, A. (2023). Uric acid as a marker of clinical severity and comorbidities in plaque psoriasis. Gaceta Médica de México, 154(4). https://doi.org/10.24875/GMM.M18000168

Ikeda, K., Morizane, S., Akagi, T., Hiramatsu-Asano, S., Tachibana, K., Yahagi, A., Iseki, M., Kaneto, H., Wada, J., Ishihara, K., Morita, Y., & Mukai, T. (2022). Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation. International Journal of Molecular Sciences, 23(8), 4312. https://doi.org/10.3390/ijms23084312

Jiang, Q., Chen, K., Liu, Y., Zhou, J., Bai, Y., Zhao, J., Weng, Y., Zhu, Y., Feng, H., Wang, J., Cai, Y., & Ou, Y. (2023). Relationship between dry skin and pressure injury in older patients: A multicentre cross‐sectional survey in China. International Wound Journal, 20(5), 1402–1417. https://doi.org/10.1111/iwj.13993

Kalinkara, V. (2023). Aging Perception and Life Satisfaction in Older Adults. Yaşlı Sorunları Araştırma Dergisi, 16(1), 23–33. https://doi.org/10.46414/yasad.1261637

Kaya, G., Kaya, A., Sorg, O., & Saurat, J.-H. (2019). Dermatoporosis, a prevalent skin condition affecting the elderly: current situation and potential treatments. Clinics in Dermatology, 37(4), 346–350. https://doi.org/10.1016/j.clindermatol.2019.04.006

Kaya, G., & Saurat, J.-H. (2007). Dermatoporosis: A Chronic Cutaneous Insufficiency/Fragility Syndrome. Dermatology, 215(4), 284–294. https://doi.org/10.1159/000107621

Kim, Z. F., Galyavich, A. S., Nurieva, I. M., & Bayazova, N. I. (2022). Skin manifestations of secondary dyslipidemia: a case report. Russian Journal of Cardiology, 27(9), 5133. https://doi.org/10.15829/1560-4071-2022-5133

Klassen, A. F., Cano, S. J., Schwitzer, J. A., Baker, S. B., Carruthers, A., Carruthers, J., Chapas, A., & Pusic, A. L. (2016). Development and psychometric validation of the FACE-Q skin, lips, and facial rhytids appearance scales and adverse effects checklists for cosmetic procedures. JAMA Dermatology, 152(4), 443–451. https://doi.org/10.1001/jamadermatol.2016.0018

Kluger, N., & Impivaara, S. (2019). Prevalence of and risk factors for dermatoporosis: a prospective observational study of dermatology outpatients in a Finnish tertiary care hospital. Journal of the European Academy of Dermatology and Venereology, 33(2), 447–450. https://doi.org/10.1111/jdv.15240

Koyano, Y., Nakagami, G., Iizaka, S., Sugama, J., & Sanada, H. (2017). Skin property can predict the development of skin tears among elderly patients: a prospective cohort study. International Wound Journal, 14(4), 691–697. https://doi.org/10.1111/iwj.12675

Kristianti, Maria T. F.; Goenawan, Hanna; Achadiyani, Achadiyani; Sylviana, Nova; Lesmana, R. (2023). The Potential Role of Vitamin D Administration in The Skin Aging Process Through The Inflammatory Pathway: A Systematic Review. Tropical Journal of Natural Product Research, 7(4). https://doi.org/10.26538/tjnpr/v7i4.1

Liu, Y., Zhao, Y., Gao, X., Liu, J., Ji, F., Hsu, Y.-C., Li, Z., & Nguyen, M. H. (2022). Recognizing skin conditions in patients with cirrhosis: a narrative review. Annals of Medicine, 54(1), 3016–3028. https://doi.org/10.1080/07853890.2022.2138961

Mellody, K. T., Bell, M., & Sherratt, M. J. (2016). The Skin Extracellular Matrix as a Target of Environmental Exposure: Molecular Mechanisms, Prevention and Repair. In Skin Stress Response Pathways (pp. 101–125). Springer International Publishing. https://doi.org/10.1007/978-3-319-43157-4_5

Mengeaud, V., Dautezac-Vieu, C., Josse, G., Vellas, B., & Schmitt, A.-M. (2012). Prevalence of dermatoporosis in elderly French hospital in-patients: a cross-sectional study. British Journal of Dermatology, 166(2), 442–443. https://doi.org/10.1111/j.1365-2133.2011.10534.x

Napolitano, M., Megna, M., & Monfrecola, G. (2015). Insulin resistance and skin diseases. TheScientificWorldJournal, 2015, 479354. https://doi.org/10.1155/2015/479354

Nicolaou, A., & Kendall, A. C. (2023). Current insights into skin lipids and their roles in cutaneous health and disease. Current Opinion in Clinical Nutrition & Metabolic Care, 26(2), 83–90. https://doi.org/10.1097/MCO.0000000000000902

Oberoi, B., Singh, S., E, A., Agarwal, R., & Jandhyala, S. (2024). Correlation of skin-related quality of life with anxiety and depression in chronic dermatoses: A cross-sectional study. Medical Journal Armed Forces India, 80(2), 178–183. https://doi.org/10.1016/j.mjafi.2023.05.004

Pradhan, M., Chettri, G., Rai, D., & Paudel, S. (2018). Cutaneous Manifestations in Patients with Chronic Kidney Disease on Hemodialysis and its Correlation with Renal Function, Dialysis Cycle and Haemoglobin. Birat Journal of Health Sciences, 3(2), 468–474. https://doi.org/10.3126/bjhs.v3i2.20963

Pulungan, A. B., Puspitadewi, A., & Sekartini, R. (2013). Prevalence of insulin resistance in obese adolescents. Paediatrica Indonesiana, 53(3), 167. https://doi.org/10.14238/pi53.3.2013.167-72

Saurat, J.-H., Mengeaud, V., Georgescu, V., Coutanceau, C., Ezzedine, K., & Taïeb, C. (2017). A simple self-diagnosis tool to assess the prevalence of dermatoporosis in France. Journal of the European Academy of Dermatology and Venereology : JEADV, 31(8), 1380–1386. https://doi.org/10.1111/jdv.14240

Sayami, A., Gupta, A., & Gautam, N. (2021). Association Between Serum Uric Acid Level and Psoriasis: A Case Control Study. Nepal Journal of Dermatology, Venereology & Leprology, 19(1), 50–54. https://doi.org/10.3126/njdvl.v19i1.35958

Shalaby, M., Elshahid, A., Metwaly, A., Ibrahim, A., Jafferany, M., & Elsaie, M. L. (2020). Therapeutic implications of C‐reactive protein and uric acid in patients with psoriasis before and after narrow band ultraviolet B therapy. Dermatologic Therapy, 33(6). https://doi.org/10.1111/dth.13823

Tyrrell, P., Harberger, S., Schoo, C., & Siddiqui, W. (2023). Kubler-Ross Stages of Dying and Subsequent Models of Grief. A Physician’s Guide to Coping with Death and Dying, 14–38. https://doi.org/10.1515/9780773572102-004

Villeneuve, D., Lidove, O., Chazerain, P., Ziza, J.-M., & Sené, T. (2020). Association between dermatoporosis and history of major osteoporotic fractures: A French prospective observational study in a general practice population. Joint Bone Spine, 87(5), 511–512. https://doi.org/10.1016/j.jbspin.2020.04.004

Yang, M., Moclair, B., Hatcher, V., Kaminetsky, J., Mekas, M., Chapas, A., & Capodice, J. (2014). A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne. Dermatology and Therapy, 4(1), 93–101. https://doi.org/10.1007/s13555-014-0052-3

Zhang, Y., Liu, L., Sun, X., Li, H., Wang, Y., Zhou, M., Hua, L., Li, B., & Li, X. (2021). Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis. Frontiers in Medicine, 8(June). https://doi.org/10.3389/fmed.2021.645550

Zheng, W., Li, H., Go, Y., Chan, X. H. (Felicia), Huang, Q., & Wu, J. (2022). Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors. Nutrients, 14(21), 4588. https://doi.org/10.3390/nu14214588




DOI: https://doi.org/10.33024/mahesa.v6i2.20813

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