Korelasi Indeks Massa Tubuh dengan Parameter Fisiologis Kulit pada Mahasiswa Fakultas Kedokteran Universitas Tarumanagara
Sari
ABSTRACT
Skin health disorders are common among young adults and can be influenced by various factors, including body mass index (BMI). Obesity is known to be associated with chronic inflammation, adipokine dysfunction, and physiological alterations of the skin; however, empirical evidence among Indonesian university students remains limited. This study aimed to analyze the relationship between BMI and skin health parameters among medical students at the Faculty of Medicine, Universitas Tarumanagara. This cross-sectional study was conducted from September to November 2025. A total of 118 respondents were selected using a total sampling technique. Height was measured using a GEA stadiometer, body weight using the Karada Omron HBF-375 scale, and skin parameters were assessed using the Smart Skin Analyzer Bitmoji. Data were analyzed using univariate and bivariate methods, with Spearman correlation applied and a significance level set at p<0,05. Most skin parameters showed no significant relationship with BMI, including sebum level, pores, spots, wrinkles, acne, comedones, pigmentation, skin sensitivity, and UV-induced acne (p>0.05). One parameter demonstrated a significant correlation: collagen level (r=0.242; p=0.008), indicating that higher BMI was associated with higher collagen levels. Conclusion: BMI was not significantly correlated with most skin health parameters; however, it showed a significant positive association with collagen levels. These findings highlight the need for further research to explore metabolic mechanisms influencing collagen integrity in young adult populations.
Keywords: Adipokines, Body Mass Index, Collagen, Skin Health, University Students.
ABSTRAK
Gangguan kesehatan kulit merupakan masalah yang umum terjadi pada dewasa muda dan dapat dipengaruhi oleh berbagai faktor, termasuk indeks massa tubuh (IMT). Obesitas diketahui berhubungan dengan inflamasi kronis, disfungsi adipokin, dan perubahan fisiologis kulit, namun bukti empiris pada populasi mahasiswa Indonesia masih terbatas. Penelitian ini bertujuan untuk menganalisis hubungan antara IMT dengan parameter kesehatan kulit pada mahasiswa Fakultas Kedokteran Universitas Tarumanagara. Penelitian menggunakan desain potong lintang dan dilakukan pada September–November 2025. Sebanyak 118 responden dipilih dengan teknik total sampling. Pengukuran tinggi badan menggunakan stadiometer GEA, berat badan menggunakan timbangan Karada Omron HBF-375, sedangkan parameter kulit diukur menggunakan Smart Skin Analyzer Bitmoji. Analisis dilakukan secara univariat dan bivariat menggunakan korelasi Spearman dengan batas kemaknaan p<0,05. Sebagian besar parameter kulit tidak menunjukkan hubungan bermakna dengan IMT, termasuk kadar sebum, pori, flek, keriput, jerawat, komedo, pigmentasi, sensitivitas, dan jerawat UV (p>0,05). Satu parameter menunjukkan korelasi signifikan, yaitu kadar kolagen (r=0,242; p=0,008), menandakan IMT yang lebih tinggi berhubungan dengan peningkatan kadar kolagen. IMT tidak berkorelasi signifikan dengan sebagian besar parameter kesehatan kulit, namun memiliki hubungan positif bermakna dengan kadar kolagen. Temuan ini menunjukkan perlunya penelitian lanjutan terhadap mekanisme metabolik yang memengaruhi integritas kolagen pada populasi dewasa muda.
Kata Kunci: Adipokin, Indeks Massa Tubuh, Kolagen, Kesehatan Kulit, Mahasiswa.
Teks Lengkap:
Download ArtikelReferensi
Achmadi, P. T., & Handayani, D. Y. (2024). Factors Associated with the Incidence of Overweight in Junior High School Students. Proceedings Series on Health & Medical Sciences, 5, 193–198. https://doi.org/10.30595/pshms.v5i.986
Ayuningtyas, D., Kusuma, D., Amir, V., Tjandrarini, D. H., & Andarwati, P. (2022). Disparities in Obesity Rates among Adults: Analysis of 514 Districts in Indonesia. Nutrients, 14(16), 3332. https://doi.org/10.3390/nu14163332
Chen, Z., Chen, Z., & Jin, X. (2023). Mendelian randomization supports causality between overweight status and accelerated aging. Aging Cell, 22(8). https://doi.org/10.1111/acel.13899
Chun, T.-H., Inoue, M., Morisaki, H., Yamanaka, I., Miyamoto, Y., Okamura, T., Sato-Kusubata, K., & Weiss, S. J. (2010). Genetic link between obesity and MMP14-dependent adipogenic collagen turnover. Diabetes, 59(10), 2484–2494. https://doi.org/10.2337/db10-0073
Cotter, C., & Walsh, S. (2021). Cutaneous sequelae of a national health crisis: Obesity and the skin. Skin Health and Disease, 1(1), e7. https://doi.org/10.1002/ski2.7
Darlenski, R., Mihaylova, V., & Handjieva-Darlenska, T. (2022). The Link Between Obesity and the Skin. Frontiers in Nutrition, 9, 855573. https://doi.org/10.3389/fnut.2022.855573
Fisher, G. J., Datta, S., Wang, Z., Li, X.-Y., Quan, T., Chung, J. H., Kang, S., & Voorhees, J. J. (2000). c-Jun–dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid. Journal of Clinical Investigation, 106(5), 663–670. https://doi.org/10.1172/JCI9362
Gündüz, B. Ö., & Ataş, H. (2023). Relationship between body mass index z-score and acne severity in adolescents: a prospective analysis. Advances in Dermatology and Allergology, 40(6), 808–813. https://doi.org/10.5114/ada.2023.133468
Guo, Z., Yang, Y., Liao, Y., Shi, Y., & Zhang, L.-J. (2022). Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity. JID Innovations : Skin Science from Molecules to Population Health, 2(1), 100064. https://doi.org/10.1016/j.xjidi.2021.100064
Heng, A. H. S., & Chew, F. T. (2020). Systematic review of the epidemiology of acne vulgaris. Scientific Reports, 10(1), 5754.
Horie, Y., Makihara, H., Horikawa, K., Takeshige, F., Ibuki, A., Satake, T., Yasumura, K., Maegawa, J., Mitsui, H., Ohashi, K., & Akase, T. (2018). Reduced skin lipid content in obese Japanese women mediated by decreased expression of rate-limiting lipogenic enzymes. PloS One, 13(3), e0193830. https://doi.org/10.1371/journal.pone.0193830
Janić, M., Janež, A., El-Tanani, M., & Rizzo, M. (2025). Obesity: Recent Advances and Future Perspectives. Biomedicines, 13(2). https://doi.org/10.3390/biomedicines13020368
Karimkhani, C., Dellavalle, R. P., Coffeng, L. E., Flohr, C., Hay, R. J., Langan, S. M., Nsoesie, E. O., Ferrari, A. J., Erskine, H. E., Silverberg, J. I., Vos, T., & Naghavi, M. (2017). Global Skin Disease Morbidity and Mortality. JAMA Dermatology, 153(5), 406. https://doi.org/10.1001/jamadermatol.2016.5538
Kiernan, K., & MacIver, N. J. (2020). The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease. Frontiers in Immunology, 11, 622468. https://doi.org/10.3389/fimmu.2020.622468
Li, Z., & Zhao, Y. (2024). Evidence of a Causal Relationship Between Body Mass Index and Immune-Mediated and Inflammatory Skin Diseases and Biomarkers: A Mendelian Randomization Study. Clinical, Cosmetic and Investigational Dermatology, Volume 17, 2659–2667. https://doi.org/10.2147/CCID.S496066
Liu, M., & Feng, J. (2023). Association between adiposity and facial aging: results from a Mendelian randomization study. European Journal of Medical Research, 28(1), 350. https://doi.org/10.1186/s40001-023-01236-x
Liu, X., Zhao, L., Chen, Y., Gao, Y., Tian, Q., Son, J. S., Chae, S. A., de Avila, J. M., Zhu, M.-J., & Du, M. (2022). Obesity induces adipose fibrosis and collagen cross-linking through suppressing AMPK and enhancing lysyl oxidase expression. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1868(9), 166454. https://doi.org/10.1016/j.bbadis.2022.166454
Ma, L., Niu, Y., Yuan, C., Bai, T., Yang, S., Wang, M., Li, Y., & Shao, L. (2023). The Characteristics of the Skin Physiological Parameters and Facial Microbiome of “Ideal Skin” in Shanghai Women. Clinical, Cosmetic and Investigational Dermatology, 16, 325–337. https://doi.org/10.2147/CCID.S400321
Ma, L., Zhang, H., Jia, Q., Bai, T., Yang, S., Wang, M., Li, Y., & Shao, L. (2024). Facial Physiological Characteristics and Skin Microbiomes Changes are Associated with Body Mass Index (BMI). Clinical, Cosmetic and Investigational Dermatology, 17, 513–528. https://doi.org/10.2147/CCID.S447412
Mori, S., Shiraishi, A., Epplen, K., Butcher, D., Murase, D., Yasuda, Y., & Murase, T. (2017). Characterization of skin function associated with obesity and specific correlation to local/systemic parameters in American women. Lipids in Health and Disease, 16(1), 214. https://doi.org/10.1186/s12944-017-0608-1
NCD Risk Factor Collaboration (NCD-RisC). (2024). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet (London, England), 403(10431), 1027–1050. https://doi.org/10.1016/S0140-6736(23)02750-2
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011). Adipokines in inflammation and metabolic disease. Nature Reviews. Immunology, 11(2), 85–97. https://doi.org/10.1038/nri2921
Palanivel, J. A., & Millington, G. W. M. (2023). Obesity-induced immunological effects on the skin. Skin Health and Disease, 3(3), e160. https://doi.org/10.1002/ski2.160
Rahmawati, N. D., Andriani, H., Wirawan, F., Farsia, L., Waits, A., & Karim Taufiqurahman, K. A. (2024). Body mass index as a dominant risk factor for metabolic syndrome among indonesian adults: a 6-year prospective cohort study of non-communicable diseases. BMC Nutrition, 10(1), 43. https://doi.org/10.1186/s40795-024-00856-8
Retiaty, F., Andarwulan, N., Palupi, N. S., Ernawati, F., Kazimierczak, R., & Średnicka-Tober, D. (2025). Contribution of Food, Energy, Macronutrients and Fiber Consumption Patterns to Obesity and Other Non-Communicable Disease Risks in the Indonesian Population. Nutrients, 17(9), 1459. https://doi.org/10.3390/nu17091459
Sarkar, R., Ranjan, R., Garg, S., Garg, V. K., Sonthalia, S., & Bansal, S. (2016). Periorbital Hyperpigmentation: A Comprehensive Review. The Journal of Clinical and Aesthetic Dermatology, 9(1), 49–55.
Su, X., Cheng, Y., & Chang, D. (2020). The Important Role of Leptin in Modulating the Risk of Dermatological Diseases. Frontiers in Immunology, 11, 593564. https://doi.org/10.3389/fimmu.2020.593564
Tham, K. W., Abdul Ghani, R., Cua, S. C., Deerochanawong, C., Fojas, M., Hocking, S., Lee, J., Nam, T. Q., Pathan, F., Saboo, B., Soegondo, S., Somasundaram, N., Yong, A. M. L., Ashkenas, J., Webster, N., & Oldfield, B. (2023). Obesity in South and Southeast Asia-A new consensus on care and management. Obesity Reviews : An Official Journal of the International Association for the Study of Obesity, 24(2), e13520. https://doi.org/10.1111/obr.13520
Vujičić, M., Broderick, I., Salmantabar, P., Perian, C., Nilsson, J., Sihlbom Wallem, C., & Wernstedt Asterholm, I. (2024). A macrophage-collagen fragment axis mediates subcutaneous adipose tissue remodeling in mice. Proceedings of the National Academy of Sciences, 121(6). https://doi.org/10.1073/pnas.2313185121
Yakupu, A., Aimaier, R., Yuan, B., Chen, B., Cheng, J., Zhao, Y., Peng, Y., Dong, J., & Lu, S. (2023). The burden of skin and subcutaneous diseases: findings from the global burden of disease study 2019. Frontiers in Public Health, 11, 1145513. https://doi.org/10.3389/fpubh.2023.1145513
Yew, Y. W., Mina, T., Ng, H. K., Lam, B. C. C., Riboli, E., Lee, E. S., Lee, J., Ngeow, J., Elliott, P., Thng, S. T. G., Chambers, J. C., & Loh, M. (2023). Investigating causal relationships between obesity and skin barrier function in a multi-ethnic Asian general population cohort. International Journal of Obesity (2005), 47(10), 963–969. https://doi.org/10.1038/s41366-023-01343-z
Zhu, L., Shen, M.-X., Samran, E., Tu, Y.-T., Chen, X., Tao, J., & Li, Y. (2021). Prevalence of acne in Chinese college students and its associations with social determinants and quality of life: a population-based cross-sectional study. Chinese Medical Journal, 134(10), 1239–1241. https://doi.org/10.1097/CM9.0000000000001292
DOI: https://doi.org/10.33024/mahesa.v6i8.23838
Refbacks
- Saat ini tidak ada refbacks.
Publisher: Universitas Malahayati Lampung

Semua artikel dapat digunakan dibawah lisensi Creative Commons Attribution-ShareAlike 4.0 International License


Panduan Penulisan





