Effect Of Serum Ferritin Levels On The Event Of Preeclampsia In Pregnant Women In First Trimester

Dinah Inrawati Agustin* -  Hasanuddin University, Indonesia
Moh Nasrum Massi -  Hasanuddin University, Indonesia
Andi Nilawati Usman -  Hasanuddin University, Indonesia
Veni Hadju -  Hasanuddin University, Indonesia
Prihantono Prihantono -  Hasanuddin University, Indonesia
Aryadi Arsyad -  Hasanuddin University, Indonesia
DOI : 10.33024/jkm.v9i4.12699

Latar Belakang Preeklamsia merupakan penyakit multisistem yang etiologinya belum diketahui, dengan manifestasi klinis yang beragam. Laporan terbaru dari WHO memperkirakan bahwa preeklampsia menyebabkan 70.000 kematian ibu setiap tahunnya di dunia. Society for the Study of Hypertension in Pregnant (ISSHP) mendefinisikan preeklamsia sebagai hipertensi de-novo dengan tekanan darah sistolik lebih tinggi dari 140 mmHg atau tekanan darah diastolik lebih tinggi dari 90 mmHg pada dua pengukuran terpisah (antara 4-6 jam). terjadi setelah usia kehamilan 20 minggu. Pemeriksaan kadar feritin serum untuk menyaring kejadian preeklamsia pada awal kehamilan sangat diperlukan karena tingginya jumlah penderita preeklamsia di Indonesia dan dampak negatif preeklamsia terhadap kehamilan.

Tujuan dari tinjauan literatur ini adalah untuk mengetahui pengaruh pemeriksaan kadar feritin serum terhadap kejadian preeklamsia pada ibu hamil trimester pertama.

Metode Beberapa database elektronik dicari untuk mengidentifikasi studi yang relevan dengan Juli 2021: Scopus, Pubmed, Google Scholar Scholar, dan PubMed. Kata kunci yang dipilih dalam pencarian mencakup 'Serum Ferritin' (dan variasinya, misalnya Ferritin dalam serum, Ferritin), dikombinasikan dengan istilah-istilah yang terkait dengan Preeklamsia termasuk 'Preeklampsia dan Kehamilan', 'Preeklamsia ibu', dan 'preeklamsia hipertensi.' Kriteria inklusi yang digunakan adalah artikel full text, menggunakan rancangan randomized controlled trial, eksperimental dan quasi eksperimen, menggunakan bahasa Indonesia dan Inggris, sampel ibu hamil dengan preeklamsia dan fokus literatur intervensi kadar feritin serum. Sebanyak 103 artikel teridentifikasi (Scopus=39; Google Scholar=23; PubMed=41).

Hasil diperoleh 19 jurnal internasional dan 11 jurnal nasional relevan. Hasil analisis menunjukkan adanya perubahan kadar feritin serum pada ibu hamil dengan preeklampsia.

Kesimpulan Kadar feritin serum yang lebih tinggi berhubungan dengan kejadian preeklamsia. Tinjauan menyeluruh ini mengkaji literatur untuk lebih memahami elemen-elemen ini, dan menggabungkan 30 artikel relevan untuk menjelaskan efektivitas pengujian serum feritin terhadap kejadian preeklamsia, serta beberapa rekomendasi untuk mengatasi masalah serius ini. Secara total, 30 artikel terkait serum feritin dan preeklampsia diidentifikasi.

Saran Perlu dikembangkan studi literatur lebih lanjut mengenai kadar feritin serum terhadap kejadian preeklampsia pada ibu hamil. Hal ini didasarkan pada beberapa temuan baru biomarker lain untuk mendeteksi kejadian preeklamsia pada ibu hamil

 

 

Kata Kunci Kadar Ferritin Serum, Preeklampsia, Ibu Hamil Trimester Pertama

 

ABSTRACT

 

Background Preeclampsia is a multisystem disease of unknown etiology, with diverse clinical manifestations. The latest report from WHO estimates that preeclampsia accounts for 70,000 maternal deaths annually in the world. The Society for the Study of Hypertension in Pregnancy (ISSHP) defines preeclampsia as de-novo hypertension with a systolic blood pressure higher than 140 mmHg or a diastolic blood pressure higher than 90 mmHg on two separate measurements (between 4-6 hours). occurs after 20 weeks of gestation. Examination of serum ferritin levels to screen for the incidence of pre-eclampsia in early pregnancy is very necessary because of the high number of patients with preeclampsia in Indonesia and the negative impact of preeclampsia on pregnancy.

The purpose of this literature review is to determine the effect of examination of serum ferritin levels on the incidence of preeclampsia in first trimester pregnant women.

Methods Several electronic databases were searched to identify studies relevant to July 2021: Scopus, Pubmed, Google Scholar Scholar, and PubMed. Keywords selected in the search included 'Serum Ferritin' (and its variations, eg Ferritin in serum, Ferritin), in combination with terms related to Preeclampsia including 'Preeclampsia and Pregnancy', 'Maternal preeclampsia,' and 'hypertension preeclampsia.' The inclusion criteria used were full text articles, using a randomized controlled trial design, experimental and quasi-experimental, using Indonesian and English, samples of pregnant women with preeclampsia and the focus of the intervention literature on serum ferritin levels. A total of 103 articles were identified (Scopus=39; Google Scholar=23; PubMed=41).

Results  19 international journals and 11 relevant national journals were obtained. The results of the analysis showed that there was a change in serum ferritin levels in pregnant women with preeclampsia.

Conclusions Higher serum ferritin levels are associated with the incidence of preeclampsia. This scoping review examines the literature to better understand these elements, and incorporates 30 relevant articles to describe the effectiveness of serum ferritin testing on the incidence of preeclampsia, as well as some recommendations to address this serious problem. In total, 30 articles related to serum ferritin and preeclampsia were identified.

Suggestion There is a need to develop further literature studies on serum ferritin levels on the incidence of preeclampsia in pregnant women. This is based on several new findings of other biomarkers for detecting the incidence of preeclampsia in pregnant women

 

Keyword : Serum Ferritin Levels, Preeclampsia, First Trimester Pregnant Women

 

Keywords : Serum Ferritin Levels, Preeclampsia, First Trimester Pregnant Women

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