REVIEW LITERATUR: PERAN SEL PENYOKONG OLFAKTORI PADA MEKANISME TERJADINYA GANGGUAN PENCIUMAN SEMENTARA PADA COVID-19

Fari Ananda Daud, Raden Aprian Surya Putra Pamungkas, Ardo Sanjaya, Julia Windi Gunadi

Sari


Latar Belakang: Infeksi dari virus SARS-CoV 2 memunculkan gejala yang bervariasi pada tiap individu. Gejala anosmia/hilangnya penghidu yang disebabkan terjadinya disfungsi pada sistem olfaktori merupakan gejala yang dialami lebih dari setengah populasi pasien COVID-19.

Tujuan: Tujuan studi ini adalah untuk mengetahui mekanisme pasti dari kerusakan jaringan, terutama pada sel penyokong olfaktori, terjadinya disfungsi olfaktori, dan mengapa dapat terjadi disfungsi olfaktori sementara pada infeksi SARS-CoV 2.

Metode: Metode studi ini adalah dengan mereview jurnal nasional dan internasional dengan topik yang berhubungan dengan tujuan studi.

Hasil: Ekspresi reseptor angiotensin-converting enzyme 2 (ACE-2) dan Transmembrane Serine Protease 2 (TMPRSS2) menjadi pemeran utama pada awal infeksi virus SARS-CoV 2 sampai terjadinya kerusakan jaringan. Olfactory sustentacular cells merupakan sel yang memiliki ekpresi yang tinggi dari kedua reseptor tersebut.

Kesimpulan: Olfactory sustentacular cells dan glial cell-derived neurotrophic factor (GDNF) yang dihasilkan oleh sel glia dapat membantu regenerasi neuron olfaktori sehingga mempercepat penyembuhan disfungsi olfaktori pada infeksi virus SARS-CoV 2.  

 


Kata Kunci


COVID-19, disfungsi olfaktori, ACE-2, TMPRSS2, sel penyokong olfaktori

Teks Lengkap:

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Referensi


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DOI: https://doi.org/10.33024/jikk.v10i8.10244

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