LITERATURE REVIEW : PHENYTOIN INDUCED-GINGIVAL OVERGROWTH

Elma Shari Pagehgiri

Sari


Abstrak: Pembesaran Gingiva yang Diinduksi Fenitoin
Fenitoin merupakan obat anti-epilepsi yang umum digunakan sebagai terapi
bangkitan tonik-klonik dan parsial. Indeks terapeutik yang sempit dan
penggunaannya yang luas meningkatkan risiko terjadinya efek samping. Insiden
pembesaran gingiva yang diinduksi fenitoin ditemukan paling banyak dibandingkan
penggunaan obat antiepilepsi lain. Kondisi ini berhubungan dengan banyak faktor
dan patogenesis pembesaran jaringan ikat disebabkan oleh beberapa faktor seperti
fibroblas, sitokin inflamasi dan sintesis matriks metalloproteinase (MMP).
Penggunaan fenitoin secara tepat harus diperhatikan dalam praktik klinis guna
mencegah efek samping yang serius.


Kata Kunci


pembesaran gingiva, pembesaran gingiva diinduksi fenitoin, fenitoin

Teks Lengkap:

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Referensi


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DOI: https://doi.org/10.33024/jikk.v10i8.10317

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