RESISTENSI ANTI JAMUR PADA DERMATOFITOSIS : LITERATURE REVIEW

Fadlan Fadilah Wahyu, Carolus Byli Pandu Eka Putra, Muhammad Fitra Wardhana Sayoeti

Sari


Dermatofitosis atau disebut juga tinea adalah sekelompok infeksi jamur yang disebabkan oleh jamur dermatofita. Telah terjadi peningkatan infeksi dermatofita yang resisten terhadap antijamur di seluruh dunia. Resistensi anti jamur awalnya tercatat di India namun kini juga dilaporkan di beberapa negara Eropa, Iran, Jepang, dan Tiongkok, serta baru-baru ini telah terjadi di Amerika Serikat. Tujuan penulisan artikel ini untuk mengkaji penelitian terdahulu mengenai resistensi anti jamur pada dermatofitosis. Penelitian ini menggunakan desain literature review, yaitu melakukan tinjauan sistematis dengan memilih artikel yang relevan dan sesuai dengan tujuan penelitian. Proses seleksi studi literatur diadaptasi dari PRISMA-ScR. Kriteria inklusi penelitian ini meliputi orisinalitas, penggunaan bahasa Inggris dan bahasa Indonesia, kata kunci meliputi dermatofita, dermatofitosis, tinea, resistensi, terbinafine, azol, dan griseovulfin. Resistensi anti jamur banyak terjadi pada terbinafine dibandingkan golongan azol. Agen penyebab dapat beragam seperti Trichophyton interdigitale, T. mentagrophytes, T. rubrum, Epidermopyton floccosum, dan Microsporum audouinii. Faktor penyebab resistensi anti jamur antara lain faktor jamur, host, obat, dan presentasi klinis. Dermatofitosis resisten anti jamur ditandai dengan dermatofitosis yang meluas dengan kekambuhan berulang setelah menjalani pengobatan yang berbeda, lesi seringkali berukuran besar dengan rasa gatal yang parah, serta keterlibatan beberapa lokasi tinea. Tatalaksana yang dapat dilakukan yaitu menaikan dosis terbinafine atau itrakonazol, penggunaan golongan azole yang baru, atau dengan terapi laser. Penggunaan anti jamur yang rasional, diagnosis dermatofitosis yang tepat dan pengujian susceptibility antijamur untuk memilih antijamur yang tepat penting dilakukan untuk keberhasilan pengobatan, sehingga dapat meningkatkan keberhasilan praktik klinis dalam mencegah infeksi dermatofita yang resisten.


Kata Kunci


Azol; dermatofita; resistensi; terbinafine; tinea

Teks Lengkap:

PDF

Referensi


Abd Elmegeed, A.S.M., Ouf, S.A., Moussa, T.A. and Eltahlawi, S.M.R (2015). Dermatophytes and other associated fungi in patients attending to some hospitals in Egypt. Brazilian Journal of Microbiology. 46: 799-805.

Appelt, L., Nenoff, P., Uhrlaß, S., Krüger, C., Kühn, P., Eichhorn, K., Buder, S., Beissert, S., Abraham, S., Aschoff, R. and Bauer, A. (2021_). Terbinafin-resistente Dermatophytosen und Onychomykose durch Trichophyton rubrum. Der Hautarzt. 72(10): 868-877.

Brescini, L., Fioriti, S., Morroni, G. and Barchiesi, F (2021). Antifungal combinations in dermatophytes. Journal of Fungi. 7(9): 727.

Burmester, A., Hipler, U.C., Hensche, R., Elsner, P. and Wiegand, C (2019). Point mutations in the squalene epoxidase gene of Indian ITS genotype VIII T. mentagrophytes identified after DNA isolation from infected scales. Medical mycology case reports. 26: 23-24.

Caplan, A.S., Chaturvedi, S., Zhu, Y., Todd, G.C., Yin, L., Lopez, A., Travis, L., Smith, D.J., Chiller, T., Lockhart, S.R. and Alroy, K.A (2023). Notes from the Field: First Reported US Cases of Tinea Caused by Trichophyton indotineae—New York City, December 2021–March 2023. Morbidity and Mortality Weekly Report. 72(19): 536.

Chowdhary, A., Singh, A., Singh, P.K., Khurana, A. and Meis, J.F (2019). Perspectives on misidentification of Trichophyton interdigitale/Trichophyton mentagrophytes using internal transcribed spacer region sequencing: urgent need to update the sequence database. Mycoses. 62(1): 11-15.

Dogra, S. and Uprety, S (2016). The menace of chronic and recurrent dermatophytosis in India: Is the problem deeper than we perceive?. Indian dermatology online journal. 7(2): 73.

Dogra, S., Shaw, D. and Rudramurthy, S.M (2019). Antifungal drug susceptibility testing of dermatophytes: Laboratory findings to clinical implications. Indian dermatology online journal. 10(3): 225.

Ebert, A., Monod, M., Salamin, K., Burmester, A., Uhrlaß, S., Wiegand, C., Hipler, U.C., Krüger, C., Koch, D., Wittig, F. and Verma, S.B (2020). Alarming India‐wide phenomenon of antifungal resistance in dermatophytes: a multicentre study. Mycoses. 63(7): 717-728.

Fattahi, A., Shirvani, F., Ayatollahi, A., Rezaei‐Matehkolaei, A., Badali, H., Lotfali, E., Ghasemi, R., Pourpak, Z. and Firooz, A (2021). Multidrug‐resistant Trichophyton mentagrophytes genotype VIII in an Iranian family with generalized dermatophytosis: report of four cases and review of literature. International Journal of Dermatology. 60(6): 686-692.

Gamage, H., Sivanesan, P., Hipler, U.C., Elsner, P. and Wiegand, C (2020). Superficial fungal infections in the department of dermatology, University Hospital Jena: a 7‐year retrospective study on 4556 samples from 2007 to 2013. Mycoses. 63(6): 558-565.

Gawaz, A.; Nenoff, P.; Uhrlaß, S.; Schaller, M (2021). Treatment of a terbinafine-resistant trichophyton mentagrophytes type VIII. Hautarzt. 72: 900–904

Hiruma, J., Noguchi, H., Hase, M., Tokuhisa, Y., Shimizu, T., Ogawa, T., Hiruma, M., Harada, K. and Kano, R (2021). Epidemiological study of terbinafine‐resistant dermatophytes isolated from Japanese patients. The Journal of Dermatology. 48(4): 564-567.

Hube, B., Hay, R., Brasch, J., Veraldi, S. and Schaller, M (2015). Dermatomycoses and inflammation: The adaptive balance between growth, damage, and survival. Journal de mycologie medicale. 25(1): e44-e58.

Khalaf, S.K., Hussain, A.F., Al-Kayalli, K.K. and Khalaf, A.K (2023). Resistant Dermatophytosis, the Causative Species, and Treatment.

Khurana, A., Sardana, K. and Chowdhary, A (2019). Antifungal resistance in dermatophytes: Recent trends and therapeutic implications. Fungal Genetics and Biology. 132: p.103255.

Kovitwanichkanont, T.; Chong, A.H (2019). Superficial fungal infections. Aust J Gen Pract. 48: 706-711

Kruithoff, C., Gamal, A., McCormick, T.S. and Ghannoum, M.A (2023). Dermatophyte Infections Worldwide: Increase in Incidence and Associated Antifungal Resistance. Life. 14(1): 1.

Martinez-Rossi, N.M., Bitencourt, T.A., Peres, N.T., Lang, E.A., Gomes, E.V., Quaresemin, N.R., Martins, M.P., Lopes, L. and Rossi, A (2018). Dermatophyte resistance to antifungal drugs: mechanisms and prospectus. Frontiers in microbiology. 9: 1108.

Pathania, S., Rudramurthy, S.M., Narang, T., Saikia, U.N. and Dogra, S (2018). A prospective study of the epidemiological and clinical patterns of recurrent dermatophytosis at a tertiary care hospital in India. Indian Journal of Dermatology, Venereology and Leprology. 84: 678.

Rudramurthy, S.M., Shankarnarayan, S.A., Dogra, S., et al., 2018. Mutation in the squalene epoxidase gene of Trichophyton interdigitale and Trichophyton rubrum associated with Allylamine resistance. Antimicrob. Agents Chemother. 62, e02522–e2617.

Salehi, Z.; Fatahi, N.; Taran, M.; Izadi, A.; Badali, H.; Hashemi, S.J.; Rezaie, S.; Daie Ghazvini, R.; Ghaffari, M.; Aala, F.; et al (2020). Comparison of in vitro antifungal activity of novel triazoles with available antifungal agents against dermatophyte species caused tinea pedis. J. Mycol. Med. 30: 100935

Sardana, K., Arora, P., Mahajan, K (2017). Intracutaneous pharmacokinetics of oral antifungals and their relevance in recalcitrant cutaneous dermatophytosis: Time to revisit basics. Indian J. Dermatol. Venereol. Leprol. 83:730–732.

Sardana, K., Khurana, A (2018). Overview of causes and treatment of recalcitrant dermatophytosis. In: Sardana, K., Khurana, A., Poojary, S., Garg, S. (Eds.), IADVL Manual on Management of Dermatophytoses. CBS Publishers, New Delhi. 80–102.

Saunte, D.M., Hare, R.K., Jørgensen, K.M., Jørgensen, R., Deleuran, M., Zachariae, C.O., Thomsen, S.F., Bjørnskov-Halkier, L., Kofoed, K. and Arendrup, M.C (2019). Emerging terbinafine resistance in Trichophyton: clinical characteristics, squalene epoxidase gene mutations, and a reliable EUCAST method for detection. Antimicrobial agents and chemotherapy. 63(10): 10-1128.

Shen, J.J.; Arendrup, M.C.; Verma, S.; Saunte, D.M.L (2021). The Emerging Terbinafine-Resistant Trichophyton Epidemic: What Is the Role of Antifungal Susceptibility Testing? Dermatology. 238: 60-79

Singh, A., Masih, A., Khurana, A., Singh, P.K., Gupta, M., Hagen, F., Meis, J.F. and Chowdhary, A (2018). High terbinafine resistance in Trichophyton interdigitale isolates in Delhi, India harbouring mutations in the squalene epoxidase gene. Mycoses. 61(7): 477-484.

Sousa, M.D.G.T.D., Santana, G.B., Criado, P.R. and Benard, G (2015). Chronic widespread dermatophytosis due to Trichophyton rubrum: a syndrome associated with a Trichophyton-specific functional defect of phagocytes. Frontiers in microbiology. 6: 801.

Suzuki, S., Mano, Y., FuruyA, N. and Fujitani, K (2018). Discovery of terbinafine low susceptibility Trichophyton rubrum strain in Japan. Biocontrol Science. 23(3): 151-154.

Uhrlaß, S., Schroedl, W., Mehlhorn, C., Krüger, C., Hubka, V., Maier, T., Gräser, Y., Paasch, U. and Nenoff, P (2018). Molecular epidemiology of Trichophyton quinckeanum–a zoophilic dermatophyte on the rise. JDDG: Journal der Deutschen Dermatologischen Gesellschaft: 16(1): 21-32.

Verma, S.; Madhu, R (2017). The great Indian epidemic of superficial dermatophytosis: An appraisal. Indian J. Dermatol. 62: 227




DOI: https://doi.org/10.33024/jikk.v11i5.13947

Refbacks

  • Saat ini tidak ada refbacks.


##submission.copyrightStatement##

##submission.license.cc.by-nc4.footer##

Pendidikan Dokter Universitas Malahayati Lampung


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.