Hubungan Nilai NLR Dengan Kadar HS-CRP Pada Pasien Talasemia Beta Mayor Anak Di RSUD Pringsewu

Komang Aditya Septa Pramana, Muhammad Nur, Selvia Anggraeni, Mulat Muliasih

Sari


Pasien talasemia beta mayor sering mengalami inflamasi kronis terjadi akibat peningkatan kadar zat besi karena transfusi darah yang dilakukan secara rutin oleh pasien, sehingga dapat mengaktifkan sistem imun serta memicu mediator inflamasi. Inflamasi ini dapat dinilai dengan parameter inflamasi, termasuk Neutrophil lymphocyte ratio (NLR) dan high sensitivity c- reactive protein (hs-CRP). Penelitian ini bertujuan untuk mengetahui hubungan antara nilai NLR dengan kadar hs-CRP pada pasien talasemia beta mayor di Rumah Sakit Umum Daerah Pringsewu. Penelitian ini merupakan penelitian kuantitatif yang menggunakan metode analitik observasional dengan desain cross sectional.  Hasil yang diperoleh pada penelitian ini yaitu pada 53 sampel yang didapatkan sebanyak 27 responden laki- laki dan 36 perempuan. Usia yang mendominasi pada kategori anak- anak (6-11 tahun) sebanyak 24 respoden. Pada uji korelasi spearman didapatkan p-value sebesar 0,533 yang lebih besar dari taraf signifikansi 0,05 (0,533 > 0,05) mengindikasikan bahwa tidak terdapat hubungan yang signifikan antara nilai NLR dengan kadar hs-CRP pada pasien talasemia beta mayor di Rumah Sakit Umum Daerah Pringsewu.


Kata Kunci


HS-CRP; NLR; Talasemia

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Referensi


Al-Talib, W. H., Althanoon, Z. A., Althanoon Zeina AAlthanoon, Z. A., & Professor, A. (2020). Effects Of Deferasirox Therapy On High Sensitivity C-Reactive Protein and Oxidative Stress Markers In Iron Overloaded, Beta-Thalassemic Patients. In Systematic Reviews in Pharmacy (Vol. 11, Issue 12).

Andalibi, M., Dehnavi, Z., Afshari, A., Tayefi, M., Esmaeili, H., Azarpazhooh, M., Mouhebati, M., Nematy, M., Heidari-Bakavoli, A., Shokri, M., Ferns, G., Ghayour-Mobarhan, M., & Tayyebi, M. (2020). Prevalence of abo and rh blood groups and their association with demographic and anthropometric factors in an iranian population: Mashad study. Eastern Mediterranean Health Journal, 26(8), 916–922. https://doi.org/10.26719/emhj.20.048

Arsyiva, A.P. (2024). Tingkat kepatuhan transfusi darah pada pasien anak dengan diagnosis thalassemia di Rumah Sakit Umum Cut Meutia Aceh Utara (Skripsi). Universitas Malikussaleh.

Banait, T., Wanjari, A., Danade, V., Banait, S., & Jain, J. (2022). Role of High-Sensitivity C-reactive Protein (Hs-CRP) in Non-communicable Diseases: A Review. Cureus. https://doi.org/10.7759/cureus.30225

Budiwiyono, I., Ap, P., Widyastiti, N. S., & Dk, K. (2021). Correlation between Ferritin Levels with Malondialdehyde and Neutrophil Lymphocyte Ratio on Iron Overload. 27(2), 147–151.

Dinh, K. M., Kaspersen, K. A., Mikkelsen, S., Pedersen, O. B., Petersen, M. S., Thørner, L. W., Hjalgrim, H., Rostgaard, K., Ullum, H.,

& Erikstrup, C. (2019). Low-grade inflammation is negatively

associated with physical Health-Related Quality of Life in healthy individuals: Results from the Danish Blood donor Study (DBDS). PLoS ONE, 14(3). https://doi.org/10.1371/journal.pone.0214468

Sarwono, E., Handayani, A. & No, J. (2021). Metode Kuantitatif Penulis. Surakarta: APPTI.

Farmakis, D., Porter, J., Taher, A., Cappellini, M. D., Angastiniotis, M., Eleftheriou, A., Alassaf, A., Angastiniotis, M., Angelucci, E., Aydinok, Y., Bou-Fakhredin Rayan, R., Brunetta, L., Cappellini, M. D., Constantinou, G., Daar, S., De Sanctis, V., Dusheiko, G., Elbard, R., Eleftheriou, A., … Yardumian, A. (2022). 2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia. HemaSphere, 6(8). https://doi.org/10.1097/HS9.0000000000000732

Gluba-Brzózka, A., Franczyk, B., Rysz-Górzyńska, M., Rokicki, R., Koziarska-Rościszewska, M., & Rysz, J. (2021). Pathomechanisms of immunological disturbances in β-thalassemia. In International Journal of Molecular Sciences (Vol. 22, Issue 18). MDPI. https://doi.org/10.3390/ijms22189677

He, J., Song, C., Zhang, R., Yuan, S., Li, J., & Dou, K. (2023). Discordance Between Neutrophil to Lymphocyte Ratio and High Sensitivity C-Reactive Protein to Predict Clinical Events in Patients with Stable Coronary Artery Disease: A Large-Scale Cohort Study. Journal of Inflammation Research, 16, 5439–5450. https://doi.org/10.2147/JIR.S428734

Kemenkes. (2022). Pedoman Penanggulangan Talasemia.

Kono, M., Matsuhiroya, S., Obuchi, A., Takahashi, T., Imoto, S.,

Kawano, S., & Saigo, K. (2020). Deferasirox, an iron-chelating agent, alleviates acute lung inflammation by inhibiting neutrophil activation and extracellular trap formation. Journal of International Medical Research, 48(9). https://doi.org/10.1177/0300060520951015

Muncie, H. L., Campbell, J. S., & Ilmu, P. (2009). Talasemia Alfa dan Beta. www.aafp.org/afp.

NI, A. (2016). Reference Values of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Mean Platelet Volume in Healthy Adults in North Central Nigeria. Journal of Blood & Lymph, 6(1). https://doi.org/10.4172/2165-7831.1000143

Notoatmodjo, & Soekidjo. (2012). Metodologi Penelitian Kesehatan. Rineka Cipta.

Porter J, Kattamis A, & Cappellini MD. (2023). Guidelines: For the Management of Transfusion Dependent Thalassaemia (TDT) (Cappellini MD, Farmakis D, & Porter J, Eds.; 4th ed.). Thalassaemia International Federation.

Prawira Veronica, & Hendrianingtyas Meita. (2018). inflamasi in iron overload. Media Medika Muda, 3, 1–4.

Rujito, L. (2019). Buku Referensi Talasemia : Genetik Dasar dan Pengelolaan Terkini.

Sara M.Nehring, Amandeep Goyal, & Bhupendra C.Patel. (2023). Protein Reaktif C. statpearls.

Sastroasmoro, S., & Ismael, S. (2014). Dasar - Dasar Metodologi Penelitian Klinis (Edisi ke-5) (Edisi ke-5). CV Sagung Seto.

Tang, Y., Liang, P., Chen, J., Fu, S., Liu, B., Feng, M., Lin, B., Lee, B., Xu, A., & Lan, H. Y. (2018). The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population. Immunity and Ageing, 15(1). https://doi.org/10.1186/s12979-018-0126-7

Nasyaira, T. (2025). Korelasi Kadar Feritin Dengan Neutrophil Lymphocyte Ratio (NLR) Pada Pasien Talasemia Beta Mayor Di RSUD Dr. H. Abdul Moeloek Bandar Lampung Tahun 2023 (Skripsi). Universitas Lampung.

Walter, P. B., Macklin, E. A., Porter, J., Evans, P., Kwiatkowski, J. L., Neufeld, E. J., Coates, T., Giardina, P. J., Vichinsky, E., Olivieri, N., Alberti, D., Holland, J., & Harmatz, P. (2008). Inflammation and oxidant-stress in β-thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: An ancillary study of the Novartis CICL670A0107 trial. Haematologica, 93(6), 817–825. https://doi.org/10.3324/haematol.11755

WHO. (2021). Data and Statistics Prevalence Thalassemia in World Wide. WHO.

Wyczalkowska-Tomasik, A., Czarkowska-Paczek, B., Zielenkiewicz, M., & Paczek, L. (2016). Inflammatory Markers Change with Age, but do not Fall Beyond Reported Normal Ranges. Archivum Immunologiae et Therapiae Experimentalis, 64(3), 249–254. https://doi.org/10.1007/s00005-015-0357-7

Yani Balaka, M., & Abyan, F. (2022). METODOLOGI PENELITIAN KUANTITATIF. www.penerbitwidina.com

Zahorec, R. (2021). Neutrophil-to-lymphocyte ratio, past, present and future perspectives. Bratislava Medical Journal, 122(7), 474–488. https://doi.org/10.4149/BLL_2021_078

Zhang, X., Li, C., Wen, T., Peng, W., Yan, L., Li, B., Yang, J., Wang, W., Xu, M. & Zeng, Y. (2017).Synchronous Splenectomy And Hepatectomy For Patients With Small Hepatocellular Carcinoma And Pathological Spleen: Neutrophil To Lymphocyte Ratio Changes Can Predict The Prognosis. Oncotarget, 8(28), Pp. 46298–46311. Doi: 10.18632/Oncotarget.17758




DOI: https://doi.org/10.33024/jikk.v12i7.20372

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