Parkinson Disease Idiopatik Stadium Lanjut Pada Pasien Lanjut Usia : Sebuah Laporan Kasus

Akbar Kami Kamajaya, Aureliany Aulia Rasyid, Azzahra Lailatul Basir, Bella Safitri, Dessy Sri Lestari, Pratiwi Hendro Putri

Sari


Parkinson disease merupakan gangguan neurodegeneratif progresif yang ditandai oleh hilangnya sel dopaminergik pada substansia nigra sehingga menyebabkan gangguan motorik dan non-motorik. Laporan kasus ini bertujuan untuk melaporkan penatalaksanaan klinis seorang pasien dengan diagnosis Parkinson disease yang menunjukkan gejala tremor istirahat, bradikinesia, rigiditas, dan gangguan keseimbangan. Diagnosis ditegakkan berdasarkan pemeriksaan klinis neurologis dan penilaian Unified Parkinson Disease Rating Scale (UPDRS), serta pemeriksaan penunjang MRI yang menunjukkan perubahan struktural ringan pada ganglia basalis. Hasil laporan kasus ini menunjukkan bahwa pendekatan terapi multimodal memberikan hasil efektif dalam meningkatkan kualitas hidup pasien dengan Parkinson disease. Kesimpulan kasus menegaskan pentingnya diagnosis dini, monitoring berkala, serta dukungan interdisipliner dalam penanganan Parkinson disease.


Kata Kunci


Levodopa; Parkinson Disease; Tremor; UPDRS; Laporan Kasus

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Referensi


Alia, S., Hidayati, H. B., Hamdan, M., Nugraha, P., Fahmi, A., Turchan, A., & Haryono, Y. (2022). Penyakit Parkinson: Tinjauan Tentang Salah Satu Penyakit Neurodegeneratif yang Paling Umum. Aksona, 1(2), 95–99. https://doi.org/10.20473/aksona.v1i2.145

Asril, A., & Nikmawati, S. (2025). Gambaran Gejala Non Motorik Penderita Penyakit Parkinson di Poliklinik Neurologi RSUD M. Natsir Solok. Scientific Journal, 4(5), 344–350. https://doi.org/10.56260/sciena.v4i5.265

Caroline Tanner, O. (2025). Neurological and Clinical Aspects of Parkinson ’ s Disease. England Journal Medicine, 4(5), 31–41.

Cilia, R., Cham, M., Obese, V., Akpalu, A., Cereda, E., Ame-bruce, E., Laryea, R., Caronni, S., Sarfo, F. S., Sorbo, F. Del, Fahn, S., & Pezzoli, G. (2025). Mucuna pruriens in untreated Parkinson ’ s disease in sub-Saharan Africa : A 12-month , multicenter , randomized , controlled trial. Journal Parkinson Disease, 4(3). https://doi.org/10.1177/1877718X251383721

Khairunnisa, I. S. Z. (2023). Parkinson Disease. Jurnal Riset Rumpun Kedokteran (Jurrike), 2(2). https://doi.org/DOI: https://doi.org/10.55606/jurrike.v2i2.1701

Lee, J. H., Park, M., Ahn, S. J., & Lee, J. H. (2025). Association of dopamine depletion and cholinergic basal forebrain atrophy with brain metabolism and cognition in Parkinson ’ s disease. Journal of Parkinson Disease. https://doi.org/10.1177/1877718X251396322

Luo, Y., Qiao, L., Li, M., Wen, X., Zhang, W., & Li, X. (2024). Global, regional, national epidemiology and trends of Parkinson’s disease from 1990 to 2021: findings from the Global Burden of Disease Study 2021. Frontiers in Aging Neuroscience, 16(January), 1–12. https://doi.org/10.3389/fnagi.2024.1498756

Rahmawati, F., & Mulyanto, J. (2024). Challenges in Parkinson’S Disease Management in Primary Care in Indonesia: a Narrative Review. Mandala Of Health, 18(1), 06. https://doi.org/10.20884/1.mandala.2025.18.1.13791

Ratna Kirani; Pratiwi Hendro Putri, T. S. (2025). Gambaran Karakteristik Demografi Pasien Parkinson Di Rumah Sakit Pertamina Bintang Amin Periode 2022-2024. Jurnal Kesehatan Malahayati, 12(6), 1167–1174.

Safwaan Rana; Abdul rehman, Q. (2024). The Global crisis of parkinson disease : epidemiologi and risk factors (pp. 1–11).

Su, D., Cui, Y., He, C., Yin, P., Bai, R., Zhu, J., Lam, J. S. T., Zhang, J., Yan, R., Zheng, X., Wu, J., Zhao, D., Wang, A., Zhou, M., & Feng, T. (2025). Projections for prevalence of Parkinson’s disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021. Bmj. https://doi.org/10.1136/bmj-2024-080952

Thomas Ppsyerhof; Bastiaan R Bloem, N. V. (2025). Daily steps and health outcomes : Implications for persons with Parkinson ’ s disease. Journal of Parkinson Disease. https://doi.org/10.1177/1877718X251397278

Thomas Stroker, J. (2018). Parkinson Disease Pathogenesis and Clinical Aspect. In Parkinson’s Disease: Pathogenesis and Clinical Aspects. https://doi.org/10.15586/codonpublications.parkinsonsdisease.2018.pr

Tunjungsari, D., Sukoandari, B., Hutagalung, H. S., Raisa, N., Nugraha, P., Tumewah, R., Marisdina, S., Sobaryati, Trisnawati, S. Y., & Subagya. (2024). Panduan Tatalaksana Penyakit Parkinson. www.uipublishing.ui.ac.id

Wang, H., Hu, J., Mo, B., Li, J., Cai, H., & Li, Q. (2025). Reactive astrocyte-related pathogenic genes in Parkinson ’ s disease : A multi- omics Mendelian randomization study. Journal of Parkinson Disease, 5(8), 1–10. https://doi.org/10.1177/1877718X251395514




DOI: https://doi.org/10.33024/jikk.v13i8.25171

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