PENGARUH EKSPRESI LMP-1 DAN P53 MUTAN DENGAN PROGNOSIS PASIEN KARSINOMA NASOFARING (UNDIFFERENTIATED TYPE)

Atikah Atikah, Udadi Sadhana, Ika Pawitra Miranti, Dik Puspasari, Vega Karlowee

Sari


Undifferentiated carcinoma merupakan subtipe KNF yang mempunyai titer antibodi EBV lebih tinggi daripada orang sehat. Efek karsinogenik EBV melibatkan LMP-1 yang berhubungan dengan buruknya prognosis sedangkan p53 mutan memprediksi kekambuhan tumor. Penelitian ini menilai pengaruh LMP-1 dan p53 mutan dengan prognosis pasien KNF (Undifferentiated carcinoma). Studi analitik observasional dengan cross-sectional di Laboratorium Patologi Anatomi RSUP Dr. Kariadi Semarang. Empat puluh buah blok parafin dari jaringan nasofaring menggunakan teknik consecutive sampling. Dilakukan pewarnaan LMP-1 dan p53 mutan. Uji statistik menggunakan uji korelasi Pearson. Nilai p < 0,05 dianggap bermakna secara statistik. Terbanyak pada kelompok usia > 40 tahun, jenis kelamin laki-laki, keterlibatan kelenjar getah bening (N) pada kelompok N2 dan tidak ada metastasis (M). Tingkat ekspresi LMP-1 dan p53 mutan terbanyak positif kuat. Korelasi antara ekspresi LMP-1 dengan usia (p=0,327), jenis kelamin (p=0,599), kategori N (p= 0,512), kategori M (p=0,019). Ekspresi p53 mutan dengan usia (p=0,329), jenis kelamin (p=0,981), kategori N (p=0,013), kategori M (p=0,705). Ekspresi LMP-1 dengan p53 mutan (p=0,760). Terdapat perbedaan antara ekspresi LMP-1 dengan p53 mutan (p=0,000). Dapat disimpulkan LMP-1 dan p53 mutan dapat digunakan sebagai faktor prognosis pada pasien KNF.

Kata Kunci


Karsinoma Nasofaring; LMP-1; p53 Mutant; Prognosis

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Referensi


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DOI: https://doi.org/10.33024/jikk.v9i1.6284

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