Hubungan Kadar Vitamin D Dengan Kadar Albumin Pada Kelompok Lanjut Usia di Panti Santa Anna

Ernawati Ernawati, Olivia Charissa, Alexander Halim Santoso, Yohanes Firmansyah, Dean Ascha Wijaya, Fernando Nathaniel, William Gilbert Satyanegara, Hans Sugiarto, Jonathan Hadi Warsito, Valentino Gilbert Lumintang, Angel Sharon Suros

Sari


ABSTRACT

 

Low albumin and vitamin D levels in the elderly are often due to factors such as malnutrition, inflammation, and illness. A deficiency in albumin can affect the availability of vitamin D because it binds to albumin. Maintaining normal levels of albumin and vitamin D in the elderly has positive impacts on nutrition, healing, infection prevention, and metabolic function. This cross-sectional study aimed to investigate the relationship between vitamin D levels and albumin levels in the elderly. It was conducted at Santa Anna Elderly Care Home in November 2023. The variables in this study were vitamin D levels and albumin levels. Statistical analysis was performed using the Mann-Whitney test. Out of 47 respondents, the average age was 77.55 years. Mann-Whitney test results indicated no significant relationship between 25-hydroxyvitamin D levels and albumin levels in blood serum (p-value: 0.770). The correlation between these two variables showed a negative correlation, meaning that lower levels of 25-hydroxyvitamin D were associated with higher albumin levels. This is interesting because it contradicts the research hypothesis, suggesting that albumin levels may be influenced by factors outside the variables being studied. The correlation result of 0.044 falls into the category of very weak and cannot be considered a determining variable between two variables. Further analysis using the Mann-Whitney test revealed that there was no significant relationship or difference in mean values between 25-hydroxyvitamin D levels in the hypoalbuminemia and normal groups (p-value: 0.919), and there was no significant relationship or difference in mean values between albumin levels in the vitamin D deficiency and normal groups.

 

Keywords: Albumin, Elderly, Vitamin D

 

 

ABSTRAK

 

Albumin dan vitamin D yang rendah pada lanjut usia dapat terjadi karena faktor malnutrisi, inflamasi, dan penyakit. Kekurangan albumin dapat memengaruhi ketersediaan vitamin D, hal ini disebabkan vitamin D terikat pada albumin. Memiliki kadar albumin dan kadar vitamin D yang normal pada lanjut usia berdampak positif pada status nutrisi, penyembuhan, pencegahan infeksi, dan fungsi metabolik. Penelitian potong lintang ini bertujuan mengetahui hubungan kadar vitamin D dengan kadar albumin pada lanjut usia yang dilakukan di Panti Lansia Santa Anna pada November 2023. Variabel dalam penelitian ini adalah kadar vitamin D dan kadar albumin. Analisis statistik menggunakan uji Mann Whitney. Dari 47 responden, rata-rata usia adalah 77,55 tahun. Hasil uji Mann Whitney menyatakan tidak terdapat hubungan yang bermakna antara kadar 25-hidroksi vitamin D dengan kadar albumin dalam serum darah (p-value: 0,770). Hasil korelasi antara kedua variabel tersebut menunjukan korelasi negatif yang berarti semakin rendah kadar 25-hidroksi vitamin D maka akan semakin tinggi kadar albumin. Hal ini cukup menarik dikarenakan berlawanan dengan hipotesis penelitian yang berarti pula sebenarnya kadar albumin disebabkan oleh banyak faktor di luar variabel yang diteliti. Hasil korelasi 0,044 masuk dalam kategori sangat lemah dan tidak dapat diperhitungkan sebagai variabel penentu antara kedua variabel. Hasil analisis lanjutan dengan uji Mann Whitney didapatkan hasil bahwa tidak terdapat hubungan atau perbedaan rerata yang bermakna antara kadar 25-hidroksi vitamin D pada kelompok hipoalbumin maupun kelompok yang normal (p-value: 0,919) serta tidak terdapat hubungan atau perbedaan rerata yang bermakna antara kadar albumin pada kelompok defisiensi vitamin D dan kelompok normal.

 

Kata Kunci: Albumin, Lanjut Usia, Vitamin D


Kata Kunci


Albumin; Lanjut Usia; Vitamin D

Teks Lengkap:

Download Artikel

Referensi


Belinskaia, D. A., Voronina, P. A., Shmurak, V. I., Jenkins, R. O., & Goncharov, N. V. (2021). Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties. International Journal of Molecular Sciences, 22(19), 10318. https://doi.org/10.3390/ijms221910318

Benedik, E. (2022). Sources of Vitamin D for Humans. International Journal for Vitamin and Nutrition Research, 92(2), 118–125. https://doi.org/10.1024/0300-9831/a000733

Bihari, S., Bannard-Smith, J., & Bellomo, R. (2020). Albumin as a Drug: Its Biological Effects Beyond Volume Expansion. CriticalCareandResuscitation : Journal of the Australasian Academy of Critical Care Medicine,22(3),257265.https://doi.org/32900333

Chiang, M.-H., Kuo, Y.-J., Chang, W.-C., Wu, Y., Lin, Y.-C., Jang, Y.-C., & Chen, Y.-P. (2021). Association of Vitamin D Deficiency with Low Serum Albumin in Taiwanese Older Adults with Hip Fracture: A Prospective Cross-Sectional Study. Journal of Nutritional ScienceandVitaminology,67(3),153162.https://doi.org/10.3177/jnsv.67.153

De Simone, G., di Masi, A., & Ascenzi, P. (2021). Serum Albumin: A Multifaced Enzyme. International Journal of Molecular Sciences, 22(18), 10086.https://doi.org/10.3390/ijms221810086

De Simone, G., Pasquadibisceglie, A., di Masi, A., Buzzelli, V., Trezza, V., Macari, G., Polticelli, F., & Ascenzi, P. (2021). Binding of Direct Oral Anticoagulants to the Site of Human Serum Albumin. Journal of Molecular Recognition,34(3).https://doi.org/10.1002/jmr.2877

di Masi, A., Leboffe, L., Polticelli, F., Tonon, F., Zennaro, C., Caterino, M., Stano, P., Fischer, S., Hägele, M., Müller, M., Kleger, A., Papatheodorou, P., Nocca, G., Arcovito, A., Gori, A., Ruoppolo, M., Barth, H., Petrosillo, N., Ascenzi, P., & Di Bella, S. (2018). Human Serum Albumin Is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication. The Journal of Infectious Diseases, 218(9), 14241435.https://doi.org/10.1093/infdis/jiy338

Dobson, R., Cock, H. R., Brex, P., & Giovannoni, G. (2018). Vitamin D supplementation. Practical Neurology, 18(1), 35–42. https://doi.org/10.1136/practneurol-2017-001720

Durmuş, S. selma, Güden, E., & Çelebi, İ. (2022). An analysis of Albumin and Vitamin D Deficiency in Patients Treated in Palliative Care Centers. Acibadem Universitesi Saglik Bilimleri Dergisi, 13(4). https://doi.org/10.31067/acusaglik.1160091

Jassil, N. K., Sharma, A., Bikle, D., & Wang, X. (2017). Vitamin D Binding Protein and 25-Hydroxyvitamin D Levels: Emerging Clinical Applications. Endocrine Practice, 23(5), 605–613.https://doi.org/10.4158/EP161604.RA

Jin, X., Xiong, S., Ju, S.-Y., Zeng, Y., Yan, L. L., & Yao, Y. (2020). Serum 25-Hydroxyvitamin D, Albumin, and Mortality Among Chinese Older Adults: A Population-based Longitudinal Study. The Journal of Clinical Endocrinology & Metabolism, 105(8), 2762–2770. https://doi.org/10.1210/clinem/dgaa349

Lai, J. C., Bikle, D. D., Lizaola, B., Hayssen, H., Terrault, N. A., & Schwartz, J. B. (2015). Total 25(OH) Vitamin D, Free 25(OH) Vitamin D and Markers of Bone Turnover in Cirrhotics with and without Synthetic Dysfunction. Liver International, 35(10), 22942300.https://doi.org/10.1111/liv.12819

Laird, E., O’Halloran, A. M., Molloy, A. M., Healy, M., Bourke, N., & Kenny, R. A. (2023). Vitamin D Status & Amp; Associations with Inflammation in Older Adults. PLOS ONE, 18(6), e0287169.https://doi.org/10.1371/journal.pone.0287169

Li, X., Cao, X., Ying, Z., Zhang, J., Sun, X., Hoogendijk, E. O., & Liu, Z. (2022). Associations of Serum Albumin With Disability in Activities of Daily Living, Mobility and Objective Physical Functioning Regardless of Vitamin D: Cross-Sectional Findings From the Chinese Longitudinal Healthy Longevity Survey. Frontiers in Nutrition, 9.https://doi.org/10.3389/fnut.2022.809499

Popovska Jovičić, B., Raković, I., Gavrilović, J., Sekulić Marković, S., Petrović, S., Marković, V., Pavković, A., Čanović, P., Radojević Marjanović, R., Irić-Čupić, V., Popović Dragonjić, L., & Milosavljević, M. Z. (2023). Vitamin D, Albumin, and D-Dimer as Significant Prognostic Markers in Early Hospitalization in Patients with COVID-19. Journal of Clinical Medicine, 12(8), 2825. https://doi.org/10.3390/jcm12082825

Pott-Junior, H., Luzeiro, C., Senise, J. F., & Castelo, A. (2020). Association of Seasonality and Serum Albumin Concentration with Vitamin D Deficiency In Subjects with Chronic Hepatitis C Infection Living in a Sunny Country. Public Health Nutrition, 23(7), 1247–1253. https://doi.org/10.1017/S1368980019004178

Remelli, F., Vitali, A., Zurlo, A., & Volpato, S. (2019). Vitamin D Deficiency and Sarcopenia in Older Persons. Nutrients, 11(12), 2861. https://doi.org/10.3390/nu11122861

Sari, D. K., Dharmajaya, R., Sari, M. I., Masyithah, D., & Hutagalung, S. V. (2018). Vitamin D, Calcium Serum Levels and Biomolecular Parameters in Active Tuberculosis Patients in North Sumatera, Indonesia. Proceedings of the International Conference of Science, Technology, Engineering, Environmental and Ramification Researches, 721725.https://doi.org/10.5220/0010085707210725

Vita, G. M., De Simone, G., Leboffe, L., Montagnani, F., Mariotti, D., Di Bella, S., Luzzati, R., Gori, A., Ascenzi, P., & di Masi, A. (2020). Human Serum Albumin Binds Streptolysin O (SLO) Toxin Produced by Group A Streptococcus and Inhibits Its Cytotoxic and Hemolytic Effects. Frontiers in Immunology11.https://doi.org/10.3389/fimmu.2020.507092

Zhu, A., Kuznia, S., Niedermaier, T., Holleczek, B., Schöttker, B., & Brenner, H. (2022). Vitamin D–Binding Protein, Total, “Nonbioavailable,” Bioavailable, and Free 25‐Hydroxyvitamin D, and Mortality in a Large Population‐Based Cohort of Older Adults. Journal of Internal Medicine, 292(3), 463–476.https://doi.org/10.1111/joim.13494




DOI: https://doi.org/10.33024/mnj.v6i2.13123

Refbacks

  • Saat ini tidak ada refbacks.


Penerbit: Universitas Malahayati


 Creative Commons License

Semua artikel dapat digunakan dibawah lisensi Creative Commons Attribution-ShareAlike 4.0 International License