ABSTRACT

Hypertension is one of the most common causes of death in the world. Insulin is a hormone that has been studied for a long time, and hyperinsulinemia is a condition where the body requires large amounts of insulin to achieve normal sugar levels. It was found that hypertensive patients with metabolic syndrome disorders have higher insulin levels with or without obesity which makes it considered as a risk factor. Finding the correlation between fasting insulin and blood pressure in nuring home. Cross-sectional study research on the correlation of fasting insulin levels with blood pressure in the elderly group at Santa Anna Nursing house. Respondents who meet the inclusion criteria will follow a series of data collection according to applicable physical and laboratory examination standards. Statistical analysis using spearman correlation analysis. There were 30 respondents who met the inclusion criteria with an average age of 73 (56 - 88) years, systolic blood pressure (SBP) 120 (105-150) mmHg, diastolic blood pressure (DBP) 70 (55-80) mmHg, and fasting insulin levels 9.45 (5.4-29.5) μIU / ml. the results of the analysis did not find a significant correlation between fasting insulin levels and blood pressure (p-value = 0.590 and 0.898). In this study, it was found that the higher the fasting insulin level, the lower the systolic blood pressure (r-systolic = -0.102). Fasting insulin is one of the tests that can be carried out as an early detection of metabolic disease, especially as a prevention of hypertension.

Keywords: Fasting Insulin, Elderly, Blood Presure

ABSTRAK

Hipertensi merupakan salah satu penyebab kematian tersering di dunia. Insulin merupakan hormon yang telah dipelajari sejak lama, dan hiperinsulinemia merupakan suatu kondisi dimana tubuh membutuhkan jumlah insulin yang banyak untuk mencapai kadar gula darah yang normal. Ditemukan bahwa pada penderita hipertensi dengan gangguan sindroma metabolik memiliki kadar insulin yang lebih tinggi baik itu dengan atau tanpa obesitas yang membuatnya dipertimbangkan sebagai faktor risiko. Meneliti bagaimana korelasi kadar insulin puasa dengan tekanan darah di panti lansia. Penelitian studi potong lintang mengenai korelasi kadar insulin puasa dengan tekanan darah pada kelompok lanjut usia di Panti Lansia Santa Anna. Responden yang memenuhi kriteria inklusi akan mengikuti rangkaian pengambilan data sesuai standar pemeriksaan fisik dan labotorium yang berlaku. Analisis statistik menggunakan analisis korelasi spearman.  Terdapat 30 responden yang memenuhi kriteria inklusi dengan rerata usia 73 (56 – 88) tahun, tekanan darah sistolik (TDS) 120 (105-150) mmHg, tekanan darah diastolik (TDD) 70 (55-80) mmHg, dan kadar insulin puasa 9,45(5,4-29,5)μIU/ml. hasil analisis tidak didapatkan korelasi yang bermakna antara kadar insulin puasa dengan tekanan darah (p-value= 0,590 dan 0,898). Pada penelitian ini didapatkan semakin tinggi kadar insulin puasa maka akan semakin rendah tekanan darah sistolik (r-sistolik=-0,102). Insulin puasa merupakan salah satu pemeriksaan yang dapat dilakukan sebagai deteksi dini penyakit metabolik, khususnya sebagai pencegahan terhadap hipertensi.  

Kata Kunci: Insulin Puasa, Lansia, Tekanan Darah

Alidu, H., Dapare, P. P. M., Quaye, L., Amidu, N., Bani, S. B., & Banyeh, M. (2023). Insulin Resistance in relation toHypertensionandDyslipidaemia among Men Clinically DiagnosedwithType2 Diabetes. BioMedResearch International, 2023,110.https://doi.org/10.1155/2023/8873226

Buford, T. W. (2016). Hypertension and aging. Ageing Research Reviews,26,96111.https://doi.org/10.1016/j.arr.2016.01.007

Chen, Y.-H., Lee, Y.-C., Tsao, Y.-C., Lu, M.-C., Chuang, H.-H., Yeh, W.-C., Tzeng, I.-S., & Chen, J.-Y. (2018). Association between high-fasting insulin levels and metabolic syndrome in non-diabetic middle-aged and elderly populations: a community-based study in Taiwan. BMJ Open, 8(5), e016554.https://doi.org/10.1136/bmjopen-2017-016554

da Silva, A. A., do Carmo, J. M., Li, X., Wang, Z., Mouton, A. J., & Hall, J. E. (2020). Role of Hyperinsulinemia and Insulin Resistance in Hypertension: Metabolic Syndrome Revisited. CanadianJournalof Cardiology, 36(5),671682.https://doi.org/10.1016/j.cjca.2020.02.066

Li, S., Huang, S., Mo, Z. N., Gao, Y., Yang, X. B., Chen, X. J., Zhao, J. M., & Qin, X. (2012). Generatinga reference interval for fasting serum insulin in healthynondiabeticadultChinese men. Singapore Medical Journal, 53(12), 821–825.

Milsom, I., & Gyhagen, M. (2019). The prevalence of urinary incontinence.Climacteric,22(3),217222.https://doi.org/10.1080/13697137.2018.1543263

Park, S. K., Jung, J. Y., Choi, W. J., Kim, Y. H., Kim, H. S., Ham, W. T., Shin, H., & Ryoo, J.-H. (2014). Elevated fasting serum insulin level predicts future development of hypertension. International Journal of Cardiology, 172(2), 450–455. https://doi.org/10.1016/j.ijcard.2014.01.087

Peplies, J., Jiménez-Pavón, D., Savva, S. C., Buck, C., Günther, K., Fraterman, A., Russo, P., Iacoviello, L., Veidebaum, T., Tornaritis, M., De Henauw, S., Mårild, S., Molnár, D., Moreno, L. A., & Ahrens, W. (2014). Percentiles of fasting serum insulin, glucose, HbA1c and HOMA-IR in pre-pubertal normal weight European children from the IDEFICS cohort. International Journal of Obesity, 38(S2), S39S47.https://doi.org/10.1038/ijo.2014.134

Singh, S., Shankar, R., & Singh, G. P. (2017). Prevalence and Associated Risk Factors of Hypertension: A Cross-Sectional Study in Urban Varanasi.https://doi.org/10.1155/2017/5491838

Thomas, D. D., Corkey, B. E., Istfan, N. W., & Apovian, C. M. (2019). Hyperinsulinemia: An Early IndicatorofMetabolicDysfunction. Journal of the Endocrine Society,3(9),17271747.https://doi.org/10.1210/js.20190006

Tibazarwa, K. B., & Damasceno, A. A. (2014). Hypertension in DevelopingCountries.Canadian Journal of Cardiology, 30(5), 527533.https://doi.org/10.1016/j.cjca.2014.02.020

Vaidya, R. A., Desai, S., Moitra, P., Salis, S., Agashe, S., Battalwar, R., Mehta, A., Madan, J., Kalita, S., Udipi, S. A., & Vaidya, A. B. (2023). Hyperinsulinemia: an early biomarkerofmetabolicdysfunction. Frontiers in Clinical Diabetes and Healthcare, 4. https://doi.org/10.3389/fcdhc.2023.1159664

Wang, F., Han, L., & Hu, D. (2017). Fasting insulin, insulin resistance and risk of hypertension in the general population: A meta-analysis. Clinica Chimica Acta, 464, 57–63.https://doi.org/10.1016/j.cca.2016.11.009