ABSTRACT

Acne Vulgaris (AV) is a chronic inflammatory skin disease affecting the pilosebaceous glands. Acne Vulgaris commonly occurs in adolescents due to hormonal fluctuations that stimulate the sebaceous glands to produce more sebum. The face, back, chest, and shoulder areas often display a predilection for AV. The aim of this study is to assess the facial sebum levels of students at SMAN 75 North Jakarta predisposed to acne vulgaris. This study used a cross-sectional design and was conducted at SMAN 75 North Jakarta in January 2024. Sampling was carried out using non-random consecutive sampling. Data obtained from the samples will be processed and analyzed using SPSS 22.0. Sebum levels were measured using a skin analyzer SK-08 on the left and right sides of the face. The characteristics of the AV group in students of SMAN 75 North Jakarta showed severe acne as many as 37 people (8.20%), moderate acne as many as 100 people (6.57%), and mild acne as many as 33 people (5.75%). Based on the Kruskal-Wallis statistical test, there was a significant difference in the average oil content between the three acne severity groups (P-value <0.001). These results indicate that increased sebum levels are associated with increased severity of acne vulgaris.

Keywords: Acne Vulgaris, Sebum Levels, Pilosebasea Glands, Skin Analyzer

ABSTRAK

Akne Vulgaris (AV) adalah penyakit kulit inflamasi kronis yang menyerang kelenjar pilosebasea. Akne Vulgaris umumnya terjadi pada remaja akibat fluktuasi hormonal yang merangsang kelenjar sebasea untuk memproduksi lebih banyak sebum. Area wajah, punggung, dada, dan bahu sering menunjukkan kecenderungan AV. Tujuan dari penelitian ini adalah untuk menilai kadar sebum wajah siswa di SMAN 75 Jakarta Utara yang rentan terhadap akne vulgaris. Penelitian ini menggunakan desain cross-sectional dan dilakukan di SMAN 75 Jakarta Utara pada bulan Januari 2024. Pengambilan sampel dilakukan dengan menggunakan non-random sequential sampling. Data yang diperoleh dari sampel akan diolah dan dianalisis menggunakan SPSS 22.0. Kadar sebum diukur menggunakan skin analyzer SK-08 pada sisi kiri dan kanan wajah. Karakteristik kelompok AV pada siswa/i SMAN 75 Jakarta Utara menunjukkan Akne berat sebanyak 37 orang (8,20%), akne sedang sebanyak 100 orang (6,57%), dan akne ringan sebanyak 33 orang (5,75%). Berdasarkan uji statistik Kruskal-Wallis, terdapat perbedaan signifikan rata-rata kadar minyak di antara ketiga kelompok tingkat keparahan akne (P-value <0,001). Hasil ini menunjukkan bahwa peningkatan kadar sebum berhubungan dengan peningkatan keparahan akne vulgaris.

Kata Kunci: Akne Vulgaris, Kadar Sebum, Kelenjar Pilosebasea, Skin Analyzer

Abdallah, M. A. R., Zuelfakkar, N. M., & Elbana, R. H. (2017). Comparative Study of Male and Female Sebum Production. The Egyptian Journal of Hospital Medicine, 69(2), 1874–1879. https://doi.org/10.12816/0040616

Afriyanti, R. N. (2015). Akne Vulgaris Pada Remaja. Journal Majority, 4(6), 102–109.

Ayudianti, P., & Indramaya, D. M. (2014). Studi Retrospektif : Faktor Pencetus Akne Vulgaris. Berkala Ilmu Kesehatan Kulit Dan Kelamin, 26(1), 1–7. https://doi.org/10.20473/BIKK.V26.1.2014.1-7

Bhadra, P., & Deb, A. (2020). A Literature Review On acne Due to Hormonal Changes and Lifestyle A Literature Review Onacne Due to Hormonal Changes and Lifestyle. Indian Journal of Natural Sciences, 10(59), 1–11. https://www.researchgate.net/publication/342216449_A_Literature_Review_Onacne_Due_to_Hormonal_Changes_and_Lifestyle

Bharti, S., & Vadlamudi, H. C. (2021). A strategic review on the involvement of receptors, transcription factors and hormones in acne pathogenesis. Journal of Receptors and Signal Transduction, 41(2), 105–116. https://doi.org/10.1080/10799893.2020.1805626

Bhate, K., & Williams, H. C. (2013). Epidemiology of acne vulgaris. In British Journal of Dermatology. https://doi.org/10.1111/bjd.12149

Bocheva, G., Slominski, R. M., & Slominski, A. T. (2023). Environmental Air Pollutants Affecting Skin Functions with Systemic Implications. International Journal of Molecular Sciences, 24(13), 10502. https://doi.org/10.3390/ijms241310502

Bungau, A. F., Radu, A. F., Bungau, S. G., Vesa, C. M., Tit, D. M., & Endres, L. M. (2023). Oxidative stress and metabolic syndrome in acne vulgaris: Pathogenetic connections and potential role of dietary supplements and phytochemicals. Biomedicine & Pharmacotherapy, 164, 115003. https://doi.org/10.1016/j.biopha.2023.115003

Clayton, R. W., Langan, E. A., Ansell, D. M., de Vos, I. J. H. M., Göbel, K., Schneider, M. R., Picardo, M., Lim, X., van Steensel, M. A. M., & Paus, R. (2020). Neuroendocrinology and neurobiology of sebaceous glands. Biological Reviews, 95(3), 592–624. https://doi.org/10.1111/brv.12579

Del Rosso, J. Q., & Kircik, L. (2024a). The cutaneous effects of androgens and androgen-mediated sebum production and their pathophysiologic and therapeutic importance in acne vulgaris. Journal of Dermatological Treatment, 35(1), 2298878.

Del Rosso, J. Q., & Kircik, L. (2024b). The primary role of sebum in the pathophysiology of acne vulgaris and its therapeutic relevance in acne management. Journal of Dermatological Treatment, 35(1), 2296855.

Dias da Rocha, M. A., Saint Aroman, M., Mengeaud, V., Carballido, F., Doat, G., Coutinho, A., & Bagatin, E. (2024). Unveiling the Nuances of Adult Female Acne: A Comprehensive Exploration of Epidemiology, Treatment Modalities, Dermocosmetics, and the Menopausal Influence. International Journal of Women’s Health, 663–678.

Do, T. H. (2020). Interactions of Human Immune Responses with Lipid Metabolism and the Skin Microbiome in Acne Vulgaris. University of California, Los Angeles.

Elizabeth, J., Tan, S. T., Angelika, M., Firmansyah, Y., Sylvana, Y., & Novendy, N. (2021). Penurunan Derajat Akne Vulgaris Setelah Penggunaan Kombinasi Krim Anti Akne Di Jakarta Barat. Jurnal Muara Sains, Teknologi, Kedokteran Dan Ilmu Kesehatan, 5(1), 19. https://doi.org/10.24912/jmstkik.v5i1.6625

Firlej, E., Kowalska, W., Szymaszek, K., Roliński, J., & Bartosińska, J. (2022). The Role of Skin Immune System in Acne. Journal of Clinical Medicine, 11(6). https://doi.org/10.3390/jcm11061579

Fournière, M., Latire, T., Souak, D., Feuilloley, M. G. J., & Bedoux, G. (2020). Staphylococcus epidermidis and Cutibacterium acnes: two major sentinels of skin microbiota and the influence of cosmetics. Microorganisms, 8(11), 1752.

Greydanus, D. E., Azmeh, R., Cabral, M. D., Dickson, C. A., & Patel, D. R. (2021). Acne in the first three decades of life: An update of a disorder with profound implications for all decades of life. Disease-a-Month, 67(4), 101103. https://doi.org/10.1016/j.disamonth.2020.101103

Honari, G., & Maibach, H. (2014). (2014). Skin Structure and Function. Applied Dermatotoxicology, 1–10. https://doi.org/10.1016/b978-0-12-420130-9.00001-3

Knutsen-Larson, S., Dawson, A. L., Dunnick, C. A., & Dellavalle, R. P. (2012). Acne Vulgaris: Pathogenesis, Treatment, and Needs Assessment. Dermatologic Clinics, 30(1). https://doi.org/10.1016/j.det.2011.09.001

Latifah dan Kurniawaty, E. (2017). Stres dengan Akne Vulgaris Stress in Acne Vulgaris. Majority, 4(9), 129–134.

Lim, S., Shin, J., Cho, Y., & Kim, K.-P. (2019). Dietary Patterns Associated with Sebum Content, Skin Hydration and pH, and Their Sex-Dependent Differences in Healthy Korean Adults. Nutrients, 11(3). https://doi.org/10.3390/nu11030619

Mardiana, Kartini, A., & Widjasena, B. (2012). Media Medika. Pemberian Cairan Karbohidrat Elektrolit, Status Hidrasi Dan Kelelahan Pada Pekerja Wanita, 46(14), 6–11.

Mayahati Nazaya, I Gusti Agung Ayu Praharsini, & Luh Made Mas Rusyati. (2018). Profil Gangguan Kualitas Hidup Akibat Akne Vulgaris Pada Mahasiswa Fakultas Kedokteran Universitas Udayana Tahun 2015. E-Jurnal Medika, 7(8), 1–5.

Mias, C., Mengeaud, V., Bessou‐Touya, S., & Duplan, H. (2023). Recent advances in understanding inflammatory acne: Deciphering the relationship between Cutibacterium acnes and Th17 inflammatory pathway. Journal of the European Academy of Dermatology and Venereology, 37(S2), 3–11. https://doi.org/10.1111/jdv.18794

Mizwar, M., Kapantow, M. G., & Suling, P. L. (2013). Profil Akne Vulgaris di RSUP Prof. Dr. R. D. Kandou Manado Periode 2009-2011. E-CliniC, 1(2). https://doi.org/10.35790/ecl.1.2.2013.3276

Nguyen, Q.-G., Markus, R., & Katta, R. (2016). Diet and acne: an exploratory survey study of patient beliefs. Dermatology Practical & Conceptual, 6(2), 21–27. https://doi.org/10.5826/dpc.0602a05

Rahmawati, D. (2012). Hubungan perawatan kulit wajah dengan timbulnya akne vulgaris. Fakultas Kedokteran Undip, 19–28. http://eprints.undip.ac.id/37467/1/Dewi.R_G2A008053_LAP_KTI.pdf

Rao, A., Douglas, S. C., & Hall, J. M. (2021). Endocrine Disrupting Chemicals, Hormone Receptors, and Acne Vulgaris: A Connecting Hypothesis. Cells, 10(6), 1439. https://doi.org/10.3390/cells10061439

Sari, A. R., Ramadhanty, P. K., Anggraeni, N., Destra, E., & Firmansyah, Y. (2023). Exploring the Connection Between Facial Skin Cleansing Habits and Acne Vulgaris: A Comprehensive Review. Medicor : Journal of Health Informatics and Health Policy, 1(1), 25–30. https://doi.org/10.61978/medicor.v1i1.42

Sugawara, E., & Nikaido, H. (2014). Histologi Dasar JUNQUEIRA Teks & Atlas. Antimicrobial Agents and Chemotherapy, 58(12), 7250–7257. https://doi.org/10.1128/AAC.03728-14

Tan, S. T., & Firmansyah, Y. (2021). New Drug Formulations For Acne Vulgaris-Pathogenesis Based Treatment Of Acne Vulgaris. Jurnal Medika Hutama, 2(04 Juli), 1021–1026. https://jurnalmedikahutama.com/index.php/JMH/article/view/206

Tan, S. T., & Firmansyah, Y. (2022). Brief and Evidence Review: Kombinasi Tretinoin, Klindamisin, dan Dexamethasone Topikal untuk Terapi Acne Vulgaris. Journal of Scientific Research, Education, and Technology (JSRET), 3(2).

Tan, S. T., Firmansyah, Y., & Elizabeth, J. (2022). Tingkatkan Kepercayaan Diri Remaja Dengan Mengontrol Acne. Jurnal Pengabdian Mandiri, 1(5), 723–730.

Tan, S. T., Yohanes Firmansyah, Hendsun Hendsun, Alicia Sarijuwita, William Gilbert Satyanegara, Joshua Kurniawan, & Dean Ascha Wijaya. (2024). Cross-Sectional Study of Efficacy, Effectiveness, and Safety of Combination Creams (Tretinoin 0.05%, Clindamycin 3%, and Dexamethasone 0.05%) Anti-Acne – An Online Study. Bioscientia Medicina : Journal of Biomedicine and Translational Research, 8(4), 4192–4200. https://doi.org/10.37275/bsm.v8i4.956

Trüeb, R. M., Dutra Rezende, H., Gavazzoni Dias, M. F. R., Silva Polito, D., & de Abreu Neves Salles, S. (2023). Bacterial Diseases. In Hair in Infectious Disease: Recognition, Treatment, and Prevention (pp. 35–127). Springer.

Vasam, M., Korutla, S., & Bohara, R. A. (2023). Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochemistry and Biophysics Reports, 36, 101578. https://doi.org/10.1016/j.bbrep.2023.101578

Veraldi, S., Barbareschi, M., Micali, G., Skroza, N., Guanziroli, E., Schianchi, R., & Tedeschi, A. (2016). Role of cleansers in the management of acne: Results of an Italian survey in 786 patients. Journal of Dermatological Treatment, 27(5), 439–442. https://doi.org/10.3109/09546634.2015.1133880

Williams HC, Dellavalle RP, & Garner S. (2012). Acne vulgaris. Lancet. https://doi.org/10.1016/S0140-6736(11)60321-8.

Yosipovitch, G., Tang, M., Dawn, A. G., Chen, M., Goh, C. L., Chan, Y. H., & Seng, L. F. (2007). Study of psychological stress, sebum production and acne vulgaris in adolescents. Acta Dermato-Venereologica, 87(2), 135–139. https://doi.org/10.2340/00015555-0231