ABSTRACT

Tuberculosis (TB) remains one of the significant global health challenges, especially in resource-limited countries. Adherence to TB treatment is key to successful therapy and preventing the emergence of drug resistance. However, dropout rates or discontinuation of treatment before completion remains a major problem that needs to be addressed. This study aims to analyze global trends in research focusing on factors affecting TB treatment adherence and dropout through a bibliometric approach. Using the Publish or Perish application, relevant scientific articles with keywords such as treatment adherence, tuberculosis, treatment dropout, and influencing factors were searched from 2017 to 2024. A total of 50 articles from Google Scholar were further analyzed to identify by publication year, country, publisher, citation, and article type. The data was then processed using VOSviewer to visualize the relationship between keywords and research trends through Network Visualization, Overlay Visualization, and Density Visualization. The results of the analysis showed that Indonesia is the country with the highest number of publications, demonstrating a great commitment in addressing the TB challenge. Articles published in reputable journals, especially those adopting systematic and meta-analysis approaches, show great impact with a high number of citations. Bibliometric visualizations reveal that the focus of research lies on factors such as treatment, adherence, health workers, and access. In addition, family and community support was also found to be an important element in ensuring treatment adherence. In conclusion, this study emphasizes the need for a comprehensive and collaborative approach in improving TB treatment adherence and preventing dropouts. Further research in this area is needed to address existing gaps and develop more effective strategies in the fight against TB.

Keywords: Treatment Adherence, Tuberculosis, Dropout, Influencing Factors, Health Worker

Aini, N., & Rahmania Hatta, H. (2017). Expert System For Diagnosing Tuberculosis Disease. Journal Of Mulawarman Informatics, 12(1), 56

Apay, F. And Rohmani, R. (2022) "Factors Affecting Treatment Success In Drug Sensitive Pulmonary Tuberculosis Patients At Rimba Jaya Health Center, Merauke Regency", Science Midwifery, 10(4), Pp. Doi: 10.35335/Midwifery.V10i4.740.

Cdc. (2016). Treatment For Tb Disease | Treatment | Tb | Centers For Disease Control And Prevention. Https://Www.Cdc.Gov/Tb/Topic/Treatment/Tbdisease.Htm

Efendi S, Sjattar El, Syam Y. (2022). Health Counseling Supports Medication Adherence To Regular Pulmonary Tuberculosis Patients. Faculty Of Nursing, Hasanuddin University, Indonesia. Elsevier

Indonesian Ministry Of Health. National Strategy For Tb Control In Indonesia 2010-2014. Jakarta; 2011

Lucena, L. A., Dantas, G. B. D. S., Carneiro, T. V., & Lacerda, H. G. (2023). Factors Associated With The Abandonment Of Tuberculosis Treatment In Brazil: A Systematic Review. Revista Da Sociedade Brasileira De Medicina Tropical, 56, E0155-2022. Https://Doi.Org/10.1590/0037-8682-0155-2022

Madeira De Oliveira, S., Altmayer, S., Zanon, M., Alves Sidney-Filho, L., Schneider Moreira, A. L., De Tarso Dalcin, P., Garcez, A., Hochhegger, B., Da Silva Moreira, J., & Watte, G. (2018). Predictors Of Noncompliance To Pulmonary Tuberculosis Treatment: An Insight From South America. Plos One, 13(9), E0202593. Https://Doi.Org/10.1371/Journal.Pone.0202593

Manurung N, Harahap Hr, Fazidah As. (2020). Family Support In Increasing Adherence To Treatment Of Tuberculosis Patients. Faculty Of Public Health, University Of North Sumatra.

Ministry Of Health Of The Republic Of Indonesia. (2014). National Guidelines For Tuberculosis Control: Tuberculosis-Free Indonesia. Ministry Of Health Of The Republic Of Indonesia, Directorate General Of Disease Control And Environmental Health.

Karuniawati, H., Ikawati, Z., & Gofir, A. (2017). Adherence To Secondary Stroke Prevention Therapies In Ischemic Stroke Patients At Teaching Hospital In Central Java Indonesia. Asian Journal Of Pharmaceutical And Clinical Research, 10(14), 28-30. Https://Doi.Org/10.22159/Ajpcr.2017.V10s2.19478

Karuniawati, H., Putra, O. N., & Wikantyasning, E. R. (2019). Impact Of Pharmacist Counseling And Leaflet On The Adherence Of Pulmonary Tuberculosis Patients In Lungs Hospital In Indonesia. Indian Journal Of Tuberculosis, 66(3), 364-369. Https://Doi.Org/10.1016/J.Ijtb.2019.02.015

Karuniawati, H., Sudjono, T. A., Utami, H. N., & Pangastuti, R. A. (2017, December). Risk Factors For Multidrug-Resistant (Mdr) In Tuberculosis Patients At Public Hospitals In Indonesia[Text]. Https://Doi.Org/Info:Doi/10.1166/Asl.2017.10794

Karuniawati, H., Wahyuni, A. S., Mirawati, H., Suryani -, & Sulistyarini -. (2015). Knowledge And Behavior Of Tuberculosis Patients Towards The Disease And Its Treatment. Proceedings Of National And International Seminar, Urecol Universitas Muhammadiyah Semarang, 0(0), Article 0. Http://103.97.100.145/Index.Php/Psn12012010/Article/View/1616

Mar'iyah, K., & Zulkarnain. (2021). Pathophysiology Of Tuberculosis Infectious Disease. Http://Journal.Uin-Alauddin.Ac.Id/Index.Php/Psb

Manurung, N., Harahap, R. H., Siregar, F. A., & Andayani, L. S. (2024). Collaboration And Involvement Of Village Heads, Public Health Officer, And Village Midwives In Improving Adherence Of Tuberculosis Patients. Clinical Epidemiology And Global Health, 26, 101528.

Nasution, Z., & Tambunan, J. L. (2020). The Relationship Between Family Support And Adherence To Taking Medication For Patients With Pulmonary Tb At The Padang Bulan Medan Health Center. In Soniar Jesica Lestari Tambunan (Vol. 2).

Sahlan Zamaa, M., Windasari, D., Pawenrusi, E., Aminullah, A., & Iskandar, Z. (2023). Relationship Between Family Support And Medication Adherence In Tuberculosis Patients. Jambura Nursing Journal, 5(2), 164-172. Doi:Https://Doi.Org/10.37311/Jnj.V5i2.19547

Tran, B. X., Wong, F. Y., Huy-Pham, K. T., Latkin, C. A., Hai-Ha, G., Thu-Vu, G., ... & Ho, R. (2019). Evolution Of Interdisciplinary Landscapes Of Hiv/Aids Studies From 1983 To 2017: Results From The Global Analysis For Policy In Research (Gap Research). Aids Reviews, 21(4).

Yang, G. Y., Wang, L. Q., Ren, J., Zhang, Y., Li, M. L., Zhu, Y. T., ... & Liu, J. P. (2015). Evidence Base Of Clinical Studies On Tai Chi: A Bibliometric Analysis. Plos One, 10(3), E0120655.

Zuhair Rd & Ismah I (2024). Risk Factors For Treatment Drop Out Among Pulmonary Tuberculosis Patients At The Upt Public Health Center In Medan Sunggal. Faculty Of Public Health, State Islamic University Of North Sumatra, Indonesia