Knowledge On Drug Safety and Drug Utilization During Pregnancy: A Review of Systematic Reviews and Meta- Analyses

Anshar Timur Samudra, Antonius Adji Prayitno Setiadi, Sylvi Irawati

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ABSTRACT

 

Drug use all through pregnancy can be beneficial or dangerous to the expectant mother, her fetus, and the baby. Some drugs have a risk of causing disability or death. Pregnant women's lack of knowledge about the harms of drug use during pregnancy can affect the use of these drugs during pregnancy. This study aims to review systematic reviews and meta-analyses regarding knowledge and use of medications during pregnancy in pregnant women. The design of this study is a scoping review using the PubMed database. The studies reviewed are systematic reviews and meta-analyses published in 2014-2024. Of the 1658 search results, five studies met the inclusion criteria. Four systematic reviews discussed drug utilization during pregnancy, and one systematic review addressed the knowledge of pregnant women regarding the use of drugs during pregnancy. The prevalence of antibiotic consumption during pregnancy ranges from 0.04 to 90%. While the prevalence of herbal medicine use in pregnant women varies between 12% and 93%. As many as 93.3% of pregnant women do not know enough about medicines and have gaps in knowledge or information about medicines, whether prescription drugs, over-the-counter drugs, or herbal medicines. Pregnant women's knowledge is also limited about the risks associated with polypharmacy in the first trimester of pregnancy, and there is a relationship between polypharmacy during pregnancy and an increased risk of congenital malformations. In conclusion, the prevalence of herbal medicine and antibiotic use during pregnancy is still relatively high. Most pregnant women do not have a good level of knowledge regarding the use of these medicines during pregnancy.

 

Keywords: Drug Utilization, Knowledge, Pregnancy


Kata Kunci


Penggunaan obat, Pengetahuan, Kehamilan

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Referensi


Atmadani, R. N., Nkoka, O., Yunita, S. L., & Chen, Y. H. (2020). Self-medication and knowledge among pregnant women attending primary healthcare services in Malang, Indonesia: A cross-sectional study. BMC Pregnancy and Childbirth, 20(1), 1–11. https://doi.org/10.1186/s12884-020-2736-2

Bouqoufi, A., Lahlou, L., Ait El Hadj, F., Abdessadek, M., Obtel, M., & Khabbal, Y. (2023). Prevalence, motivation, and associated factors of medicinal herbs consumption in pregnant women from Eastern Mediterranean Regional Office: a systematic review. Pharmaceutical Biology, 61(1), 1065–1081. https://doi.org/10.1080/13880209.2023.2229388

Brandon Bookstaver, P., Bland, C. M., Griffin, B., Stover, K. R., Eiland, L. S., & McLaughlin, M. (2015). A review of antibiotic use in pregnancy. Pharmacotherapy, 35(11), 1052–1062. https://doi.org/10.1002/phar.1649

Briggs, G.G., Freeman, R.K., Towers, C.V., et al. (2017) Drug in pregnancy and lactation. 11th ed, Philadelphia: Wolters Kluwer, pp. 4575

Briggs, G.G., Towers, C.V., Forinash, A.B., (2022) Drugs in pregnancy and lactation. 12th ed, Philadelphia: Wolters Kluwer

Cleveland Clinic, (2022) ‘Teratogens’ [online]. Available from: https://my.clevelandclinic.org/health/articles/24325-teratogens [Accessed: 12 October 2024)

Crockett J, Sumankuuro J, Soyen C, Ibrahim M, Ngmenkpieo F, Wulifan JK. (2020). Women’s motivation and associated factors for herbal medicine use during pregnancy and childbirth: a systematic review. Health. 12(06):572–597. doi: 10.4236/health.2020.126044.

Joint Formulary Committee (2023) BNF 85. London: BMJ Publishing Group Ltd and the Royal Pharmaceutical Society of Great Britain

Kirubarajan, A., Lam, A., Yu, A., Taheri, C., Khan, S., Sethuram, C., Olivieri, N. (2021). Knowledge, Information Sources, and Institutional Trust of Patients Regarding Medication Use in Pregnancy: A Systematic Review. Journal of Family & Reproductive Health, 15(3). https://doi.org/10.18502/jfrh.v15i3.7133

Law, R., Bozzo, P., Koren, G., (2010) ‘Motherisk Update FDA pregnancy risk categories and the CPS’ 56, pp.239–241

Liu, X., Liew, Z., Olsen, J., Pedersen, L. H., Bech, B. H., Agerbo, E., Li, J. (2015). Association of prenatal exposure to acetaminophen and coffee with childhood asthma. Pharmacoepidemiology and Drug Safety, 25(2), 188–195. doi:10.1002/pds.3940

Miller, J. E., Wu, C., Pedersen, L. H., De Klerk, N., Olsen, J., & Burgner, D. P. (2018). Maternal antibiotic exposure during pregnancy and hospitalization with infection in offspring: A population-based cohort study. International Journal of Epidemiology, 47(2), 561–571. https://doi.org/10.1093/ije/dyx272

Mudonhi, N., & Nunu, W. N. (2022). Traditional Medicine Utilisation Among Pregnant Women in Sub-saharan African Countries: A Systematic Review of Literature. Inquiry (United States), 59. https://doi.org/10.1177/00469580221088618

Navaro, M., Vezzosi, L., Santagati, L., et al. (2018) ‘Knowledge, attitudes, and practice regarding medication use in pregnant women in Southern Italy’ PLoS ONE, 13(6): e0198616 [online]. DOI: 10.1371/journal.pone.0198618

Orwa, S. A., Gudnadottir, U., Boven, A., Pauwels, I., Versporten, A., Vlieghe, E., & Brusselaers, N. (2024). Global prevalence of antibiotic consumption during pregnancy: A systematic review and meta-analysis. Journal of Infection, 89(2), 106189. https://doi.org/10.1016/j.jinf.2024.106189

Palamut, S.Ç., Yurdakul, M., (2022) ‘Rational drug use and associated factors in pregnant women’ Women & Health, 63(1), 8-16 [online]. DOI: 10.1080/03630242.2022.2148805

Panganai, T., & Shumba, P. (2016). The African Pitocin - A midwife’s dilemma: The perception of women on the use of herbs in pregnancy and labour in Zimbabwe, Gweru. Pan African Medical Journal, 25, 1–7. https://doi.org/10.11604/pamj.2016.25.9.7876

Thunbo, M. Ø., Vendelbo, J. H., Volqvartz, T., Witte, D. R., Larsen, A., & Pedersen, L. H. (2022). Polypharmacy in polymorbid pregnancies and the risk of congenital malformations—A systematic review. Basic and Clinical Pharmacology and Toxicology, 130(3), 394–414. https://doi.org/10.1111/bcpt.13695

Tricco, A. C., Lillie, E., Zarin, W., O’Brien, K. K., Colquhoun, H., Levac, D., … Straus, S. E. (2018). PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Annals of Internal Medicine, 169(7), 467. doi:10.7326/m18-0850

Wibowo, I.M.P., Brata, C. (2023) 'Drug use during pregnancy and lactation' in Setiadi, A.P., Brata, C., Wibowo, Y.I. (eds.) Clinical pharmacy: towards optimal treatment for patients. 2nd ed. Surabaya: Directorate of Scientific Publishing and Publications, University of Surabaya




DOI: https://doi.org/10.33024/mnj.v7i6.20651

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