ABSTRACT

Atherogenic dyslipidemia is one of the major risk factors for cardiometabolic complications in patients with type 2 diabetes mellitus (T2DM). The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL) ratio is commonly used as an indicator of cardiometabolic risk. However, the association between the degree of glycemic control and the TG/HDL ratio remains inconsistent. To determine the association between the degree of glycemic control (HbA1c) and the TG/HDL ratio as a predictor of cardiometabolic risk in patients with T2DM. This cross-sectional study included 84 T2DM patients attending the internal medicine outpatient clinic at a hospital. Data were analyzed using Chi-square test, Spearman correlation, logistic regression, and Kruskal–Wallis test. There was no significant association between glycemic control categories and the TG/HDL ratio (p=0.702). Logistic regression analysis also revealed no significant result (p=0.703). The Spearman correlation between HbA1c and the TG/HDL ratio was not statistically significant (r = -0.062; p = 0.574). The Kruskal–Wallis test yielded a p-value of 0.890. No significant association was found between the degree of glycemic control and the TG/HDL ratio as a predictor of cardiometabolic risk in patients with T2DM. Further studies with better control of confounding variables and larger sample sizes are warranted.

Keywords: Type 2 Diabetes Mellitus, Glycemic Control, Hba1c, TG/HDL Ratio,  Cardiometabolic Risk, Atherogenic Dyslipidemia.

Altun, Ö., & Kalyon, S. (2023). The Role Of Triglyceride-Hdl Ratio And Triglyceride-Glucose Index In Estimating Glycemic Control In Patients With Type 2 Diabetes Mellitus. Meandros Medical And Dental Journal, 23(1), 74-79.

Anggraini, D., Oktora, M.Z. & Hasni, D., (2025). Peran Indeks Aterogenik Sebagai Penanda Komplikasi Pada Diabetes Melitus Tipe 2: Tinjauan Pustaka. Scientic Journal, 4(2), Pp.91–99. Available At: Http://Journal.Scientic.Id/Index.Php/Sciena/Issue/View/25

Babic, N., Valjevac, A., Zaciragic, A., Avdagic, N., Zukic, S., & Hasic, S. (2019). The Triglyceride/Hdl Ratio And Triglyceride Glucose Index As Predictors Of Glycemic Control In Patients With Diabetes Mellitus Type 2. Medical Archives, 73(3), 163.

Bays, H.E., (2020). Ten Things To Know About Ten Cardiovascular Disease Risk Factors (“Aspc Top Ten – 2020”). American Journal Of Preventive Cardiology, 1, P.100003. Https://Doi.Org/10.1016/J.Ajpc.2020.100003

Chen, Y., Chang, Z., Liu, Y., Zhao, Y., Fu, J., Zhang, Y., Liu, Y., Fan, Z., (2022). Triglyceride To High-Density Lipoprotein Cholesterol Ratio And Cardiovascular Events In The General Population : A Systematic Review And Meta-Analysis Of Cohort Studies, Nutr Metab Cardiovasc Dis. 32(2), 318–329. Https://Doi.Org/10.1016/J.Numecd.2021.11.005

De Almeida-Pititto, B., Branda, J.I., De Oliveira, J.M., Dualib, P.M., De Aquino Fernandes Dias, L.B., Bensenor, I.M., Lotufo, P.A., Ferreira, S.R.G., (2024). The Predictive Value Of The Triglycerides/Hdl-Cholesterol Ratio For Diabetes Incidence. Endocrines, 5(1), Pp 418–429. Https://Doi.Org/10.3390/Endocrines5030031

Ezquerra, E.A., Castellano Vázquez, J.M. & Alegría Barrero, A., (2008). Obesity, Metabolic Syndrome And Diabetes: Cardiovascular Implications And Therapy. Revista Española De Cardiología (English Edition), 61(7), Pp.752–764. Https://Doi.Org/10.1016/S1885-5857(08)60212-1

Gedikli, M.A., Sari Kalin, B. & Aktaş, A., (2022). Relationship Between Hba1c Level And Triglyceride/Hdl Cholesterol Ratio And Triglyceride Glucose Index In Diabetes Patients. Bagcilar Medical Bulletin, 7(1), Pp.27–31. Https://Doi.Org/10.4274/Bmb.Galenos.2022.2021-09-095

International Diabetes Federation (Idf). (2021). Idf Diabetes Atlas, 10th Edition. Brussels, Belgium: Idf

Kementerian Kesehatan Ri. (2024). Survey Kesehatan Indonesia 2023. Jakarta: Kemenkes Ri.

Leavens, K.F. & Birnbaum, M.J., (2011). Insulin Signaling To Hepatic Lipid Metabolism In Health And Disease. Critical Reviews In Biochemistry And Molecular Biology, 46(3), Pp.200–215. Https://Doi.Org/10.3109/10409238.2011.562481

Rusdiana, R., Widjaja, S.S. & Savira, M., (2020). The Relation Between Lipid Profile And Glycemic Control In Type 2 Diabetes Mellitus Patients In North Sumatera, Indonesia. Open Access Macedonian Journal Of Medical Sciences, 8(B), Pp.887–891. Https://Doi.Org/10.3889/Oamjms.2020.5174 .

Setyawati, N. M. D. L. (2024). Implementasi Latihan Relaksasi Otot Progresif Pada Pasien Diabetes Melitus Tipe 2 Dengan Risiko Ketidakstabilan Kadar Glukosa Darah Di Rsud Tabanan (Doctoral Dissertation, Poltekkes Kemenkes Denpasar Jurusan Keperawatan 2024).

Suryati, I. (2021). Buku Keperawatan Latihan Efektif Untuk Pasien Diabetes Mellitus Berbasis Hasil Penelitian. Deepublish.

Yang, M., Rigdon, J., & Tsai, S. A. (2019). Association Of Triglyceride To Hdl Cholesterol Ratio With Cardiometabolic Outcomes. Journal Of Investigative Medicine, 67(3), 663-668.

Yudha, N.S.D., Arsana, P.M. & Rosandi, R., (2021). Comparison Of Lipid Profiles In Patients With Type 2 Diabetes Mellitus With Good Glycemic Control And Poor Glycemic Control In Rsud Dr. Saiful Anwar Malang. Jurnal Penyakit Dalam Indonesia, 8(4), Article 2. Https://Doi.Org/10.7454/Jpdi.V8i4.592.