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Faktor yang Berhubungan dengan Fatigue Pada Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisis di RS H.L. Manambai Abdulkadir Sumbawa
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ABSTRACT
Fatigue affects 60 to 80 percent of patients with chronic kidney disease undergoing hemodialysis. A local preliminary survey showed that 60 percent of patients experienced severe fatigue. However, studies integrating physiological, psychological, clinical, and healthcare access factors within a single analytical model remain limited. Factors associated with fatigue and the most dominant factor among patients with chronic kidney disease undergoing hemodialysis were identified in this study. This quantitative observational analytic study employed a cross sectional approach. From a population of 69 patients, 59 respondents were selected using the Slovin formula and purposive sampling. Data were collected between 4 and 18 June 2026 using the FACIT-F, the HARS, and a medical record observation form. Data were analyzed using the Chi Square test and binary logistic regression with SPSS. The largest proportion of respondents experienced severe fatigue (35.6 percent). Bivariate analysis showed that hemoglobin level (p = 0.003; OR = 5.556), comorbidities (p = 0.001; OR = 6.111), anxiety (p = 0.028; OR = 3.429), and duration of hemodialysis (p = 0.046; OR = 2.923) were significantly associated with fatigue. Hemodialysis frequency (p = 0.250) and distance to the facility (p = 0.902) were not significantly associated. Multivariate analysis showed that hemoglobin level was the most dominant factor (AOR = 13.534; p = 0.002), followed by comorbidities (AOR = 11.759; p = 0.002) and anxiety (AOR = 5.183; p = 0.034). Duration of hemodialysis was no longer significant after adjustment (p = 0.078). Fatigue assessment in hemodialysis units should be integrated with hematological monitoring, comorbidity identification, and psychological screening, with anemia control as the primary priority.
Keywords: Anxiety, Chronic Kidney Disease, Fatigue, Hemodialysis, Hemoglobin Level.
ABSTRAK
Fatigue dialami 60 sampai 80 persen pasien gagal ginjal kronik yang menjalani hemodialisis. Survei awal setempat menunjukkan 60 persen pasien mengalami fatigue berat. Namun, kajian yang mengintegrasikan faktor fisiologis, psikologis, klinis, dan akses layanan dalam satu model analisis masih terbatas. Diketahuinya faktor yang berhubungan dengan fatigue serta faktor paling dominan pada pasien gagal ginjal kronik yang menjalani hemodialisis diidentifikasi melalui penelitian ini. Penelitian kuantitatif analitik observasional ini menggunakan pendekatan potong lintang. Dari populasi 69 pasien, sebanyak 59 responden dipilih menggunakan rumus Slovin dan teknik purposive sampling. Data dikumpulkan pada 4 sampai 18 Juni 2026 menggunakan FACIT-F, HARS, dan lembar observasi rekam medis. Analisis dilakukan menggunakan uji Chi Square dan regresi logistik biner dengan SPSS. Proporsi terbesar responden mengalami fatigue berat sebesar 35,6 persen. Analisis bivariat menunjukkan kadar hemoglobin (p = 0,003; OR = 5,556), penyakit penyerta (p = 0,001; OR = 6,111), kecemasan (p = 0,028; OR = 3,429), dan lama hemodialisis (p = 0,046; OR = 2,923) berhubungan signifikan dengan fatigue. Frekuensi hemodialisis (p = 0,250) dan jarak ke fasilitas (p = 0,902) tidak berhubungan signifikan. Analisis multivariat menunjukkan kadar hemoglobin merupakan faktor paling dominan (AOR = 13,534; p = 0,002), diikuti penyakit penyerta (AOR = 11,759; p = 0,002) dan kecemasan (AOR = 5,183; p = 0,034). Lama hemodialisis tidak lagi signifikan setelah dikontrol (p = 0,078). Pengkajian fatigue di unit hemodialisis perlu diintegrasikan dengan pemantauan status hematologis, identifikasi komorbiditas, dan skrining psikologis, dengan pengendalian anemia sebagai prioritas utama.
Kata Kunci: Fatigue, Gagal Ginjal Kronik, Hemodialisis, Kadar Hemoglobin, Kecemasan.
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Al Naamani, Z., Gormley, K., Noble, H., Santin, O., & Al Maqbali, M. (2021). Fatigue, Anxiety, Depression And Sleep Quality In Patients Undergoing Haemodialysis. Bmc Nephrology, 22(1), 157.
Alshammari, B., Alkubati, S. A., Alrasheeday, A., Pasay-An, E., Edison, J. S., Madkhali, N., Al-Sadi, A. K., Altamimi, M. S., Alshammari, S. O., Alshammari, A. A., & Alshammari, F. (2024). Factors Influencing Fatigue Among Patients Undergoing Hemodialysis: A Multi-Center Cross-Sectional Study. Libyan Journal Of Medicine, 19(1), 2301142. Https://Doi.Org/10.1080/19932820.2023.2301142
Alshraifeen, A., Al‐Rawashdeh, S., Alnuaimi, K., Alzoubi, F., Tanash, M., Ashour, A., Al‐Hawamdih, S., & Al‐Ghabeesh, S. (2020). Social Support Predicted Quality Of Life In People Receiving Haemodialysis Treatment: A Cross‐Sectional Survey. Nursing Open, 7(5), 1517–1525.
Amal, A. I., Melastuti, E., & Putri, M. P. (2026). Lama Menjalani Hemodialisis Dan Kualitas Hidup Pasien Gagal Ginjal Kronik: Korelasi Keduanya. Jurnal Medika Nusantara, 4(1), 74–83. Https://Doi.Org/10.59680/Medika.V4i1.2185
Amalia, R., Ratih, W. U., & Suryanto, S. (2025). Hubungan Kadar Hemoglobin Dengan Ureum Berdasarkan Frekuensi Hemodialisa Pada Pasien Gagal Ginjal Kronik Di Rumah Sakit Soerojo Kota Magelang. Anakes: Jurnal Ilmiah Analis Kesehatan, 11(1), 190–201.
Attamimi, H. R., Nuryanto, I. K., & Yunita, E. (2026). Metode Penelitian Kesehatan. In Teoretis, Aplikatif, Dan Kontekstual Era Digital. Pt Media Penerbit Indonesia.
Cahyati, Y., & Rosdiana, I. (2022). Contribution Of Anxiety And Dialysis Factors To The Event Of Fatigue In Hemodialysis Patient. Enfermería Nefrológica, 25(2), 156–161.
Casaux-Huertas, A., Sánchez-Tocino, M. L., San Juan-Miguelsanz, M., Audije-Gil, J., Romero-Lugo, N., Muñoz-Pilar, S., Da Pena-Vielba, F., Hernan-Gascueña, D., Manso-Del Real, P., Escribano-Loma, S., Sánchez-Beato, C. C., Arenas-Jiménez, M. D., Research Unit, F. R. E., & Fragildial Working Group, F. R. E. (2026). Fatigue And Related Sleep Disturbances In Hemodialysis Patients: Prevalence, Associated Factors, And The Influence Of Nutritional Status. In Nutrients (Vol. 18, Issue 1, P. 124). Https://Doi.Org/10.3390/Nu18010124
Cella, D., De La Loge, C., Fofana, F., Guo, S., Ellis, A., Fleurinck, C., Massow, U., Dougados, M., Navarro-Compán, V., & Walsh, J. A. (2024). The Functional Assessment Of Chronic Illness Therapy–Fatigue (Facit-Fatigue) Scale In Patients With Axial Spondyloarthritis: Psychometric Properties And Clinically Meaningful Thresholds For Interpretation. Journal Of Patient-Reported Outcomes, 8(1), 92.
Dahlan, M. S. (2016). Statistik Untuk Kedokteran Dan Kesehatan: Seri 1 (Edisi 6). Salemba Medika.
Dasgupta, I., Bagnis, C. I., Floris, M., Furuland, H., Zurro, D. G., Gesualdo, L., Heirman, N., Minutolo, R., Pani, A., & Portolés, J. (2024). Anaemia And Quality Of Life In Chronic Kidney Disease: A Consensus Document From The European Anaemia Of Ckd Alliance. Clinical Kidney Journal, 17(8), Sfae205.
Facit. (2024). Facit Scoring Guidelines. Https://Www.Facit.Org/Scoring
Faioli, A., Bergesio, G., Samà, C., & Gallo, B. (2024). Predictors Of Fatigue Among Patients On Hemodialysis: An Observational Study. Cureus, 16(8).
Gregg, L. P., Bossola, M., Ostrosky-Frid, M., & Hedayati, S. S. (2021). Fatigue In Ckd: Epidemiology, Pathophysiology, And Treatment. Clinical Journal Of The American Society Of Nephrology, 16(9), 1445–1455.
Haddiya, I., Simanjuntak, G. D. F. I., & Ramdani, S. (2025). Updates In The Management Of Intradialytic Hypotension: Emerging Strategies And Innovations. World Journal Of Nephrology, 14(4), 109168.
Hamilton, M. (1959). Hamilton Anxiety Rating Scale. British Journal Of Medical Psychology.
Hosseini, M., & Soltanian, M. (2022). Application Of Roy’s Adaptation Model In Clinical Nursing: A Systematic Review. Journal Of Iranian Medical Council.
Irr. (2024). 17th Annual Report Of Indonesian Renal Registry. Indonesian Renal Registry. Https://Www.Indonesianrenalregistry.Org
Jhamb, M., Weisbord, S. D., Steel, J. L., & Unruh, M. (2008). Fatigue In Patients Receiving Maintenance Dialysis: A Review Of Definitions, Measures, And Contributing Factors. American Journal Of Kidney Diseases, 52(2), 353–365.
Kartika, D., & Hayati, N. (2024). Fatigue Pada Pasien Hemodialisa. Jurnal Pendidikan Tambusai, 8(1), 1123–1130. Https://Garuda.Kemdiktisaintek.Go.Id/Documents/Detail/4354079
Kdigo. (2024). Kdigo 2024 Clinical Practice Guideline For The Evaluation And Management Of Chronic Kidney Disease. Kidney International, 105(4), S117–S314.
Kemenkes Ri. (2023). Keputusan Menteri Kesehatan Republik Indonesia Nomor Hk.01.07/Menkes/1634/2023 Tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Penyakit Ginjal Kronik. Kementerian Kesehatan Republik Indonesia. Https://Kemkes.Go.Id/App_Asset/File_Content_Download/17019170696571318d16eff8.41286905.Pdf
Khemchandani, M., Nasir, K., Qureshi, R., Dhrolia, M., & Ahmad, A. (2023). From Exhaustion To Empowerment: Investigating Fatigue And Its Associations In Patients With End-Stage Renal Disease On Maintenance Hemodialysis. Cureus, 15(11).
Kristanti, F. (2025). Prediktor Kecemasan Pada Pasien Chronic Kidney Disease (Ckd) Di Ruang Hemodialisis Rumah Sakit Panti Rapih Yogyakarta. Jurnal Ilmiah Keperawatan Imelda, 11(1), 104–107. Http://Jurnal.Uimedan.Ac.Id/Index.Php/Jurnalkeperawatan
Maesaroh, S., Waluyo, A., & Jumaiyah, W. (2020). Faktor-Faktor Yang Berhubungan Dengan Terjadinya Fatigue Pada Pasien Hemodialisis. Syntax Literate: Jurnal Ilmiah Indonesia, 5(6), 321–330. Https://Jurnal.Syntaxliterate.Co.Id/Index.Php/Syntax-Literate/Article/View/1074
Maharani, N. D., Widayati, N., & Nistiandani, A. (2025). Interdialytic Weight Gain And Fatigue In Chronic Kidney Disease Patients Undergoing Hemodialysis: A Correlational Study. Nursing And Health Sciences Journal, 5(2). Https://Doi.Org/10.53713/Nhsj.V5i2.482
Mailani, F., Mansur, A. R., Rifdatunnisa, A., & Chan, C. M. (2025). Factors Related To Fatigue Among Chronic Kidney Disease Patients On Hemodialysis. Nurse Media Journal Of Nursing; Vol 15, No 1 (2025): (April 2025)Do - 10.14710/Nmjn.V15i1.59980 . Https://Ejournal.Undip.Ac.Id/Index.Php/Medianers/Article/View/59980
Maisyaroh, A., Maslufin, M., Fibriyanti, D. O., Widianto, E. P., & Kurnianto, S. (2024). Anemia And Fatigue In Patients With Chronic Kidney Failure. Jurnal Kesehatan Manarang, 10(1), 51–58.
Mardiyah, A., Julianti, E., Zulkifli, Z., Giovana, L., & Raharjo, D. T. (2026). Association Between Hemoglobin Levels, Duration Of Hemodialysis, And Mental Health Outcomes In Ckd Patients: A Cross-Sectional Study. Journal Of Applied Nursing And Health, 8(1), 837–850.
Mark, P. B., Stafford, L. K., Grams, M. E., Aalruz, H., Abd Elhafeez, S., Abdelgalil, A. A., Abdulkader, R. S., Abeywickrama, H. M., Abiodun, O. O., & Abramov, D. (2025). Global, Regional, And National Burden Of Chronic Kidney Disease In Adults, 1990–2023, And Its Attributable Risk Factors: A Systematic Analysis For The Global Burden Of Disease Study 2023. The Lancet, 406(10518), 2461–2482.
Maulidiyah, D. D., Murtaqib, M., & A’la, M. Z. (2024). Hubungan Fatigue Dengan Kualitas Hidup Pada Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisis Di Rsd Dr. Soebandi Jember. Jurnal Ilmiah Ners Indonesia, 5(2), 81–89.
Musniati, M., Muhsinin, S. Z., & Puspitasari, P. (2020). Gambaran Fatigue Pada Pasien Hemodialisa Di Rsup Ntb. Jurnal Keperawatan Dan Kebidanan, 12(2), 7–11. Https://E-Journal.Lppmdianhusada.Ac.Id/Index.Php/Jkk/Article/View/101
Namimi-Halevi, C., Keinan-Boker, L., Dichtiar, R., Beckerman, P., & Bromberg, M. (2025). Travel Distance To Dialysis And Mortality Among Hemodialysis Patients In A Geographically Small Country. Journal Of Community Health, 1–12.
Nugrahandari, D., Setyani, S., & Suparmi, S. (2024). Faktor-Faktor Yang Mempengaruhi Fatigue Pada Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisis Rutin. Jurnal Penelitian Kesehatan, 12(1), 55–63. Https://Garuda.Kemdiktisaintek.Go.Id/Documents/Detail/4789611
Nurmansyah. (2025). Fatigue, Kualitas Tidur Dan Kualitas Hidup Pada Pasien Gagal Ginjal Kronik. Jurnal Keperawatan, 13(1), 151–160. Https://Ejournal.Unsrat.Ac.Id/V3/Index.Php/Jkp/Article/Download/63727/50323/161136
Ortiz, A., Lees, J. S., Torra, R., Stel, V. S., Kramer, A., & Mark, P. B. (2026). The Updated Global Burden Of Chronic Kidney Disease: One Death Every 20 Seconds. Nephrology Dialysis Transplantation, Gfag040. Https://Doi.Org/10.1093/Ndt/Gfag040
Ozen, N., Eyileten, T., Teles, P., Seloglu, B., Gurel, A., Ocuk, A., Ozen, V., Fernandes, F., Campos, L., & Coutinho, S. (2025). Impact Of Variables On Recovery Time In Patients Undergoing Hemodialysis: An International Survey. Bmc Nephrology, 26(1), 13.
Pallant, J. (2020). Spss Survival Manual: A Step By Step Guide To Data Analysis Using Ibm Spss (7th Ed.). Mcgraw-Hill Education.
Portolés, J., Martín, L., Broseta, J. J., & Cases, A. (2021). Anemia In Chronic Kidney Disease: From Pathophysiology And Current Treatments, To Future Agents. Frontiers In Medicine, Volume 8-. Https://Www.Frontiersin.Org/Journals/Medicine/Articles/10.3389/Fmed.2021.642296
Prastiwi, F., Ta, W., & Ddsl, I. (2022). Correlational Analysis Of Physiological And Psychological Factors With Fatigue On Chronic Kidney Disease Patients Undergoing Hemodialysis. Jurnal Aisyah: Jurnal Ilmu Kesehatan, 7(1), 85–92.
Prastiwi, F., Wihastuti, T. A., & Ismail, D. D. S. L. (2025). Faktor Yang Berhubungan Dengan Kelelahan Pada Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisis. Jurnal Kesehatan, 18(1), 56–65.
Pratiwi, D., Hamzah, A., Erlina, E., & Setiawan, R. (2024). Hubungan Lama Menjalani Hemodialisa Dengan Kelelahan Pasien Chronic Kidney Disease. Jurnal Keperawatan Indonesia Florence Nightingale, 3(1), 25–32. Https://Garuda.Kemdiktisaintek.Go.Id/Documents/Detail/4740991
Putra, A. T. A. (2025). Metodologi Penelitian Kuantitatif Dan Kualitatif. In Teoretis & Praktis. Amerta Media.
Rahmawati, I., & Windartik, E. (2025). Hemoglobin (Hb) Values Correlated With Fatigue In Patients Undergoing Hemodialysis. Jurnal Ners Dan Kebidanan (Journal Of Ners And Midwifery), 12(3), 203–212.
Santoso, D., Sawiji, S., Oktantri, H., & Septiwi, C. (2022). Faktor-Faktor Yang Berhubungan Dengan Fatigue Pada Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisa Di Rsud Dr. Soedirman Kebumen. Jurnal Ilmiah Kesehatan Keperawatan, 18(1), 60–70.
Saraswati, N. L. G. I., & Lestari, N. K. Y. (2024). Tingkat Fatigue Pada Pasien Yang Menjalani Hemodialisis. Journal Nursing Research Publication Media, 3(2), 75–82. Https://Doi.Org/10.55887/Nrpm.V3i2.128
Sharif-Nia, H., Marôco, J., Froelicher, E. S., Barzegari, S., Sadeghi, N., & Fatehi, R. (2024). The Relationship Between Fatigue, Pruritus, And Thirst Distress With Quality Of Life Among Patients Receiving Hemodialysis: A Mediator Model To Test Concept Of Treatment Adherence. Scientific Reports, 14(1), 9981. Https://Doi.Org/10.1038/S41598-024-60679-2
Siam, B. G. A. E., Ali, W. G. M., Elzeky, M. E. H., & Heggy, E. H. Y. (2025). Factors Predicting Fatigue Among Patients Undergoing Hemodialysis. Frontiers Of Nursing, 12(3).
Sugiyono. (2025). Metode Penelitian Kuantitatif (3rd Ed.). Alfabeta.
Sukron. (2025). Manajemen Post Dialysis Effect: Fatigue Oleh Pasien End Stage Renal Disease (Esrd). Jurnal Inspirasi Kesehatan, 3(1), 66–74. Https://Doi.Org/10.52523/Jika.V3i1.159
Sulistni, R., & Damanik, H. D. L. (2021). Anxiety Stress And Fatigue In Hemodialysis Patient. First International Conference On Health, Social Sciences And Technology (Icohsst 2020), 88–91.
Sutisna, Y. I., Pramana, K. D., Fermananda, I. R., & Syuhada, I. (2025). Korelasi Kepatuhan Hemodialisis Dan Kualitas Hidup Pada Pasien Penyakit Ginjal Tahap Akhir Di Rsud Provinsi Ntb. Indonesian Journal Of Health Research Innovation, 2(3), 133–141.
Syavalia, M. R., Qodir, A., Soelistyoningsih, D., & Rifa’i, A. (2026). Faktor-Faktor Yang Terkait Dengan Kejadian Fatigue Pada Pasien Gagal Ginjal Kronis Yang Menjalani Terapi Hemodialisis: Factors Associated With Incidence Of Fatigue In Chronic Kidney Disease Patients On Hemodialysis Therapy. Journal Of Health, 13(1), 85–95.
Wang, G., Yi, X., Fan, H., & Cheng, H. (2024). Anxiety And Sleep Quality In Patients Receiving Maintenance Hemodialysis: Multiple Mediating Roles Of Hope And Family Function. Scientific Reports, 14(1), 15073.
Xia, A., Meuleman, Y., Dekker, F. W., & Hoogeveen, E. K. (2025). Risk Factors And Potential Treatments For Fatigue In Patients With Advanced Ckd: A Narrative Review. In Kidney And Dialysis (Vol. 5, Issue 1, P. 8). Https://Doi.Org/10.3390/Kidneydial5010008
Yunandari, N. P., Lestarini, I. A., & Asmara, I. G. Y. (2024). Karakteristik Anemia Pada Pasien Hemodialisis Rutin Di Rsud Provinsi Ntb. Lombok Medical Journal, 3(1), 34–37. Https://Doi.Org/10.29303/Lmj.V3i1.3693
Zhang, Y., Yang, N., Bai, X., Liu, Y., Li, X., Yan, M., & Liu, Y. (2025). Factors Affecting Postdialysis Fatigue Among Hemodialysis Patients: A Multi-Group Path Analysis According To Nutritional Status. Frontiers In Medicine, 12, 1553751.
DOI: https://doi.org/10.33024/mnj.v8i9.27691
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